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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
83
Citations
23007
World Ranking
2966
National Ranking
66

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award
  • 2010 - Fellow of the Royal Society of Canada Academy of Science

Overview

X. Chris Le is affiliated with the University of Alberta in Canada and has a significant body of research in biochemistry, genetics, molecular biology, and environmental science. Their work spans multiple subfields including molecular biology, infectious diseases, biomedical engineering, health toxicology, mutagenesis, and environmental chemistry.

Their research topics cover advanced biosensing and bioanalysis techniques, biosensors and analytical detection, CRISPR and genetic engineering, SARS-CoV-2 detection and testing, arsenic contamination and mitigation, heavy metal exposure and toxicity, and RNA interference and gene delivery.

Frequent co-authors collaborating with X. Chris Le include:

  • Hongquan Zhang
  • Hanyong Peng
  • Wei Feng
  • Xing-Fang Li
  • Jeffrey Tao

Their work has been published extensively in several scientific venues, with notable frequency in:

  • Analytical Chemistry
  • Journal of Environmental Sciences
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Environmental Science & Technology

Some of the recent publications authored or coauthored by X. Chris Le include:

  • "Molecular Diagnosis of COVID-19: Challenges and Research Needs," 2020, Analytical Chemistry
  • "CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules," 2021, Chemical Science
  • "Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology," 2020, Analytical Chemistry
  • "The CRISPR-Cas toolbox for analytical and diagnostic assay development," 2021, Chemical Society Reviews
  • "Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA," 2021, Analytical Chemistry

X. Chris Le was awarded the Fellow of the Royal Society of Canada by the Academy of Science in 2010. This recognition highlights their contributions within the scientific community.

Best Publications

  • Rolling circle amplification: A versatile tool for chemical biology, materials science and medicine

    M. Monsur Ali;Feng Li;Feng Li;Zhiqing Zhang;Zhiqing Zhang;Kaixiang Zhang;Kaixiang Zhang

  • Arsenic binding to proteins.

    Shengwen Shen;Xing-Fang Li;William R. Cullen;Michael Weinfeld

  • Arsenic speciation analysis.

    Zhilong Gong;Xiufen Lu;Mingsheng Ma;Corinna Watt

  • A microRNA-initiated DNAzyme motor operating in living cells

    Hanyong Peng;Xing-Fang Li;Hongquan Zhang;X. Chris Le

  • DNA-Mediated Homogeneous Binding Assays for Nucleic Acids and Proteins

    Hongquan Zhang;Feng Li;Brittany Dever;Xing-Fang Li

  • Speciation of key arsenic metabolic intermediates in human urine.

    X. Chris Le;Xiufen Lu;Mingsheng Ma;William R. Cullen

  • Aptamer binding assays for proteins: The thrombin example-A review

    Bin Deng;Yanwen Lin;Chuan Wang;Feng Li

  • Molecular Diagnosis of COVID-19: Challenges and Research Needs.

    Wei Feng;Ashley M. Newbigging;Connie Le;Bo Pang

  • Selection and analytical applications of aptamers

    Camille L.A. Hamula;Jeffrey W. Guthrie;Hongquan Zhang;Xing-Fang Li

  • Biotransformation of arsenic by a Yellowstone thermoacidophilic eukaryotic alga.

    Jie Qin;Corinne R. Lehr;Chungang Yuan;X. Chris Le

  • Binding-induced fluorescence turn-on assay using aptamer-functionalized silver nanocluster DNA probes.

    Jingjing Li;Jingjing Li;Xiaoqin Zhong;Hongquan Zhang;X. Chris Le

  • Exponential Isothermal Amplification of Nucleic Acids and Assays for Proteins, Cells, Small Molecules, and Enzyme Activities: An EXPAR Example.

    Michael S. Reid;X. Chris Le;Hongquan Zhang

  • Electrochemical DNAzyme Sensor for Lead Based on Amplification of DNA−Au Bio-Bar Codes

    Li Shen;Zhong Chen;Yihan Li;Shali He

  • Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic.

    Unknown

  • CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules

    Wei Feng;Ashley M. Newbigging;Jeffrey Tao;Yiren Cao

  • Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.

    X. Chris Le;X. Chris Le;X. Chris Le;James Z. Xing;James Z. Xing;James Z. Xing;Jane Lee;Jane Lee;Jane Lee;Steven A. Leadon;Steven A. Leadon;Steven A. Leadon

  • Speciation of Submicrogram per Liter Levels of Arsenic in Water: On-Site Species Separation Integrated with Sample Collection

    X. Chris Le;Serife Yalcin;Mingsheng Ma

  • Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine.

    X C Le;M Ma;W R Cullen;H V Aposhian

  • Unstable trivalent arsenic metabolites, monomethylarsonous acid and dimethylarsinous acid

    Zhilong Gong;Xiufen Lu;William R. Cullen;X. Chris Le

  • Effect of arsenosugar ingestion on urinary arsenic speciation

    Mingsheng Ma;X. Chris Le

  • Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology.

    Bo Pang;Jingyang Xu;Yanming Liu;Hanyong Peng

  • Excretion of arsenic in urine as a function of exposure to arsenic in drinking water.

    R L Calderon;E Hudgens;X C Le;D Schreinemachers

  • Disruption of the Arsenic (+3 Oxidation State) Methyltransferase Gene in the Mouse Alters the Phenotype for Methylation of Arsenic and Affects Distribution and Retention of Orally Administered Arsenate

    Zuzana Drobna;Hua Naranmandura;Kevin M. Kubachka;Brenda C. Edwards

Frequent Co-Authors

Xing-Fang Li
Xing-Fang Li University of Alberta
Michael Weinfeld
Michael Weinfeld University of Alberta
Hailin Wang
Hailin Wang Chinese Academy of Sciences
Samuel Monroe Cohen
Samuel Monroe Cohen University of Nebraska Medical Center
William R. Cullen
William R. Cullen University of British Columbia
Lizhong Zhu
Lizhong Zhu Zhejiang University
Bin Hu
Bin Hu Wuhan University
D. Lorne Tyrrell
D. Lorne Tyrrell University of Alberta
David J. Thomas
David J. Thomas Environmental Protection Agency
Martin J. Zuidhof
Martin J. Zuidhof University of Alberta

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