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Derek A. Pratt

Derek A. Pratt

D-Index & Metrics

Chemistry

D-Index
69
Citations
18125
World Ranking
6151
National Ranking
160

Overview

Derek A. Pratt is affiliated with the University of Ottawa in Canada. Their research spans multiple disciplines, primarily focused on Chemistry, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these fields, they have contributed extensively to subfields such as Organic Chemistry, Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, and Biochemistry.

The scientist's main research topics include radical photochemical reactions, ferroptosis and cancer prognosis, free radicals and antioxidants, cancer, lipids, and metabolism, RNA modifications and cancer, catalytic C-H functionalization methods, and sulfur-based synthesis techniques.

Frequent co-authors collaborating with Derek A. Pratt include Corey R. J. Stephenson, Zijun Wu, Marcus Conrad, Jia-Fei Poon, and Bettina Proneth.

They have published notably in several scientific venues, with the highest number of publications appearing in the Journal of the American Chemical Society. Other frequent publication venues include Nature, Angewandte Chemie International Edition, Nature Chemical Biology, and Chemical Science.

Among recent publications authored by Derek A. Pratt are:

  • Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers, 2020, Nature Chemical Biology
  • A non-canonical vitamin K cycle is a potent ferroptosis suppressor, 2022, Nature
  • Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury, 2021, Nature Communications
  • 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis, 2024, Nature
  • Ferroptosis in health and disease, 2024, Redox Biology

Best Publications

  • FSP1 is a glutathione-independent ferroptosis suppressor

    Sebastian Doll;Florencio Porto Freitas;Ron Shah;Maceler Aldrovandi

  • On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death.

    Omkar Zilka;Ron Shah;Bo Li;José Pedro Friedmann Angeli

  • The chemical basis of ferroptosis

    Marcus Conrad;Derek A. Pratt

  • Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis.

    Ron Shah;Mikhail S. Shchepinov;Derek A. Pratt

  • Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.

    Mariluz Soula;Ross A. Weber;Omkar Zilka;Hanan Alwaseem

  • Ferroptosis Inhibition: Mechanisms and Opportunities

    Jose Pedro Friedmann Angeli;Ron Shah;Derek A. Pratt;Marcus Conrad

  • Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

    Keith U Ingold;Derek A Pratt

  • Free radical oxidation of polyunsaturated lipids: New mechanistic insights and the development of peroxyl radical clocks.

    Derek A. Pratt;Keri A. Tallman;Ned A. Porter

  • Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis

    Claus Schneider;Derek A. Pratt;Derek A. Pratt;Ned A. Porter;Alan R. Brash

  • Theoretical Study of X−H Bond Energetics (X = C, N, O, S): Application to Substituent Effects, Gas Phase Acidities, and Redox Potentials

    G. A. DiLabio;D. A. Pratt;and A. D. LoFaro;J. S. Wright

  • Radicals in natural product synthesis

    Kevin J Romero;Matthew S Galliher;Derek A Pratt;Corey R J Stephenson

  • Critical re-evaluation of the O-H bond dissociation enthalpy in phenol.

    Peter Mulder;Hans-Gert Korth;Derek A Pratt;Gino A DiLabio

  • Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.

    Wulf Tonnus;Claudia Meyer;Christian Steinebach;Alexia Belavgeni

  • Dissecting the mechanisms of a class of chemical glycosylation using primary 13C kinetic isotope effects

    Min Huang;Graham E. Garrett;Graham E. Garrett;Nicolas Birlirakis;Luis Bohé

  • The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death.

    Ron Shah;Kaitlyn Margison;Derek A. Pratt

  • 5-Pyrimidinols: novel chain-breaking antioxidants more effective than phenols.

    Derek A. Pratt;Gino A. DiLabio;Giovanni Brigati;Gian Franco Pedulli

  • Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids.

    Derek A. Pratt;Jeremy H. Mills;Ned A. Porter

  • Garlic: Source of the Ultimate Antioxidants—Sulfenic Acids†

    Vipraja Vaidya;Keith U. Ingold;Derek A. Pratt

  • 6-Amino-3-Pyridinols: Towards Diffusion-Controlled Chain-Breaking Antioxidants

    Maikel Wijtmans;Derek A. Pratt;Luca Valgimigli;Gino A. DiLabio

  • Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin

    Markus Griesser;Valentina Pistis;Takashi Suzuki;Noemi Tejera

Frequent Co-Authors

Luca Valgimigli
Luca Valgimigli University of Bologna
Ned A. Porter
Ned A. Porter Vanderbilt University
Gino A. DiLabio
Gino A. DiLabio University of British Columbia
Gian Franco Pedulli
Gian Franco Pedulli University of Bologna
Corey R. J. Stephenson
Corey R. J. Stephenson University of Michigan–Ann Arbor
Marcus Conrad
Marcus Conrad Helmholtz Zentrum München
Keith U. Ingold
Keith U. Ingold National Research Council Canada
Jeffrey Atkinson
Jeffrey Atkinson Brock University
Alan R. Brash
Alan R. Brash Vanderbilt University
David Crich
David Crich University of Georgia

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