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Chemistry

D-Index
82
Citations
21039
World Ranking
3149
National Ranking
1046

Biology and Biochemistry

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87
Citations
24127
World Ranking
2869
National Ranking
1474

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Alan R. Brash is affiliated with Vanderbilt University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with specialized attention to areas such as molecular biology, biochemistry, and organic chemistry. Additional subfields include nutrition and dietetics as well as pharmaceutical science.

The scientist's work encompasses a range of topics related to lipid metabolism, signaling pathways, and bioactive lipids. Key topics include eicosanoids and hypertension pharmacology, sphingolipid metabolism and signaling, fatty acid research and health, lipid metabolism and biosynthesis, advancements in transdermal drug delivery, metabolomics and mass spectrometry studies, and organic chemistry cycloaddition reactions.

Frequent collaborators in their research activities include Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell. These collaborative efforts have contributed to a stable body of work published mainly in specific research venues.

Brash has a substantial record of publications in the following venues:

  • Journal of Biological Chemistry
  • Journal of Lipid Research
  • Nature Communications
  • Chemical Reviews
  • Free Radical Research

Some of the recent notable papers include:

  • "Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples," 2023, Nature Communications
  • "Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions," 2021, Journal of Lipid Research
  • "Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function," 2020, Journal of Biological Chemistry
  • "Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes," 2021, Journal of Lipid Research
  • "Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.," 2021, Apollo (University of Cambridge)

Alan R. Brash was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2013, recognizing their contributions to the scientific community.

Best Publications

  • Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate

    Alan R. Brash

  • Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

    G A FitzGerald;J A Oates;J Hawiger;R L Maas

  • Arachidonic acid as a bioactive molecule

    Alan R. Brash

  • Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation.

    Garret A. FitzGerald;Bruce Smith;Anders K. Pedersen;Alan R. Brash

  • Release of Prostaglandin D2 into Human Airways during Acute Antigen Challenge

    J J Murray;A B Tonnel;A R Brash;L J Roberts nd

  • Discovery of a second 15S-lipoxygenase in humans

    Alan R. Brash;William E. Boeglin;Min S. Chang

  • The Structure of Human 5-Lipoxygenase

    Nathaniel C. Gilbert;Sue G. Bartlett;Maria T. Waight;David B. Neau

  • Two Distinct Pathways of Formation of 4-Hydroxynonenal MECHANISMS OF NONENZYMATIC TRANSFORMATION OF THE 9- AND 13-HYDROPEROXIDES OF LINOLEIC ACID TO 4-HYDROXYALKENALS

    Claus Schneider;Keri A. Tallman;Ned A. Porter;Alan R. Brash

  • Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis

    Claus Schneider;Derek A. Pratt;Derek A. Pratt;Ned A. Porter;Alan R. Brash

  • Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides.

    Wen-Chao Song;Colin D. Funk;Alan R. Brash

  • Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation

    Claus Schneider;Ned A. Porter;Alan R. Brash

  • Estimated rate of prostacyclin secretion into the circulation of normal man.

    Garret A. Fitzgerald;Alan R. Brash;Pierre Falardeau;John A. Oates

  • Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450

    Wen-Chao Song;Alan R. Brash

  • Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

    H Kuhn;J Belkner;R Wiesner;A R Brash

  • Prostacyclin production during pregnancy: comparison of production during normal pregnancy and pregnancy complicated by hypertension.

    Robert P. Goodman;Allen P. Killam;Alan R. Brash;Robert A. Branch

  • 15S-Hydroxyeicosatetraenoic Acid Activates Peroxisome Proliferator-activated Receptor γ and Inhibits Proliferation in PC3 Prostate Carcinoma Cells

    Scott B. Shappell;Rajnish A. Gupta;Suzanne Manning;Robert Whitehead

  • A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

    William E. Boeglin;Richard B. Kim;Alan R. Brash

  • A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation

    Gianguido Coffa;Alan R. Brash

  • The structural basis for specificity in lipoxygenase catalysis

    Marcia E Newcomer;Alan R Brash

  • Expression of a Flax Allene Oxide Synthase cDNA Leads to Increased Endogenous Jasmonic Acid (JA) Levels in Transgenic Potato Plants but Not to a Corresponding Activation of JA-Responding Genes.

    Karsten Harms;Rainer Atzorn;Alan Brash;Hartmut Kuhn

Frequent Co-Authors

John A. Oates
John A. Oates Vanderbilt University
Thomas M. Harris
Thomas M. Harris Vanderbilt University
Shozo Yamamoto
Shozo Yamamoto Kyoto Women's University
Ned A. Porter
Ned A. Porter Vanderbilt University
Garret A. FitzGerald
Garret A. FitzGerald University of Pennsylvania
Richard B. Kim
Richard B. Kim University of Western Ontario
Natsuo Ueda
Natsuo Ueda Kagawa University
Ian A. Blair
Ian A. Blair University of Pennsylvania
John Turk
John Turk Washington University in St. Louis
Joshua Rokach
Joshua Rokach Florida Institute of Technology

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