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Chemistry

D-Index
45
Citations
6889
World Ranking
16510
National Ranking
4105

Overview

Theodore R. Holman is affiliated with the University of California, Santa Cruz in the United States. Their research primarily focuses on biochemical and molecular biology aspects related to lipoxygenase enzymes, eicosanoids, and their implications in health and disease.

Their work spans the fields of biochemistry, genetics, molecular biology, and medicine, with notable contributions in subfields including biochemistry, molecular biology, nutrition and dietetics, pharmacology, and cardiology and cardiovascular medicine.

The main topics covered in Holman's research are:

  • Eicosanoids and Hypertension Pharmacology
  • Fatty Acid Research and Health
  • Inflammatory mediators and NSAID effects
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Cancer, Lipids, and Metabolism

Recent papers authored or co-authored by Holman include:

  • Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis (2020, Redox Biology)
  • 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5 (2020, Journal of Lipid Research)
  • Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death (2024, Angewandte Chemie International Edition)
  • Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators (2020, Biochemistry)
  • DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway (2020, Journal of Thrombosis and Haemostasis)

Frequent collaborators in Holman's research include:

  • Michael Holinstat
  • Adriana Yamaguchi
  • Chakrapani Kalyanaraman
  • Matthew P. Jacobson
  • Steve Perry

Holman's publications are commonly found in several scientific venues. Most frequent publication venues include:

  • Biochemistry
  • Blood
  • Archives of Biochemistry and Biophysics
  • Journal of Clinical and Translational Science
  • Journal of Lipid Research

Best Publications

  • PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

    Sally E. Wenzel;Yulia Y. Tyurina;Jinming Zhao;Claudette M. St. Croix

  • N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

    Saravanan S. Karuppagounder;Lauren Alin;Yingxin Chen;David Brand

  • Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

    Joshua D. Deschamps;Victor A. Kenyon;Theodore R. Holman

  • Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147.

    Gerard D. Wright;Theodore R. Holman;Christopher T. Walsh

  • Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.

    Diana R. Tomchick;Phuc Phan;Marcin Cymborowski;Wladek Minor

  • Structure−Activity Relationship Studies of Nordihydroguaiaretic Acid Inhibitors toward Soybean, 12-Human, and 15-Human Lipoxygenase

    Stephanie Whitman;Mikail Gezginci;Barbara N Timmermann;Theodore R Holman

  • A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors.

    Rachana V Ohri;Alexander T Radosevich;K James Hrovat;Christine Musich

  • Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium

    Theodore R. Holman;Zhen Wu;Barry L. Wanner;Christopher T. Walsh

  • Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

    Taro Amagata;Stephanie Whitman;Tyler A. Johnson;Chad C. Stessman

  • Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis.

    Tamil S. Anthonymuthu;Yulia Y. Tyurina;Wan-Yang Sun;Karolina Mikulska-Ruminska

  • Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO.

    Kaushik Ghosh;Aura A Eroy-Reveles;Belem Avila;Theodore R Holman

  • Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

    Yesseny Vasquez-Martinez;Rachana V. Ohri;Victor Kenyon;Theodore R. Holman

  • Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors.

    Jennifer Carroll;Erika N. Jonsson;Rainer Ebel;Michael S. Hartman

  • Models for diferrous forms of iron-oxo proteins. Structure and properties of [Fe2BPMP(O2CR)2]BPh4 complexes

    A. S. Borovik;M. P. Hendrich;T. R. Holman;E. Munck

  • Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

    Ganesha Rai;Netra Joshi;Joo Eun Jung;Yu Liu

  • Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

    Diane K. Luci;J. Brian Jameson;Adam Yasgar;Giovanni Diaz

  • Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

    Victor Kenyon;Ilya Chorny;Wendy J. Carvajal;Theodore R. Holman

  • Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

    Kenneth N. Ikei;Jennifer Yeung;Patrick L. Apopa;Jesús Ceja

  • Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.

    Jennifer Yeung;Benjamin E. Tourdot;Pilar Fernandez-Perez;Joanne Vesci

  • Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

    Robert H. Cichewicz;Victor A. Kenyon;Stephanie Whitman;Nancy M. Morales

  • Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.

    Robert H. Cichewicz;Laura J. Clifford;Peter R. Lassen;Xiaolin Cao

  • Discovery of Platelet-Type 12-Human Lipoxygenase Selective Inhibitors by High-Throughput Screening of Structurally Diverse Libraries

    Joshua D. Deschamps;Jeffrey T. Gautschi;Stephanie Whitman;Tyler A. Johnson

Frequent Co-Authors

Ajit Jadhav
Ajit Jadhav Pfizer (Germany)
Anton Simeonov
Anton Simeonov National Institutes of Health
Matthew P. Jacobson
Matthew P. Jacobson University of California, San Francisco
Phillip Crews
Phillip Crews University of California, Santa Cruz
Jerry L. Nadler
Jerry L. Nadler New York Medical College
Valerian E. Kagan
Valerian E. Kagan University of Pittsburgh
Hülya Bayır
Hülya Bayır University of Pittsburgh
Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
Rajiv R. Ratan
Rajiv R. Ratan Cornell University
Eng H. Lo
Eng H. Lo Harvard University

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