World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
82
Citations
23747
World Ranking
1516
National Ranking
752

Overview

Rajiv R. Ratan is affiliated with Cornell University in the United States and has produced research primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, including Molecular Biology, Neurology, Physiology, Immunology, and Pulmonary and Respiratory Medicine.

The scientist's research topics cover a range of areas including:

  • Immune cells in cancer
  • Ferroptosis and cancer prognosis
  • Cancer, Hypoxia, and Metabolism
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Interferon and immune responses
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Epigenetics and DNA Methylation

Among the recent papers featuring Rajiv R. Ratan's contributions are:

  • "Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience," 2023, Nature Neuroscience
  • "The Chemical Biology of Ferroptosis in the Central Nervous System," 2020, Cell Chemical Biology
  • "Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage," 2021, Science Immunology
  • "2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience," 2023, Neuron
  • "The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease," 2020, Neurobiology of Disease

Frequent coauthors collaborating with Rajiv R. Ratan include:

  • Saravanan S. Karuppagounder
  • Amit Kumar
  • Sadaf Amin
  • Gillian Carling
  • Man Ying Wong

Publications by Rajiv R. Ratan have appeared multiple times in notable venues such as:

  • Neuron
  • Neurobiology of Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Nature Neuroscience

This combination of publication venues reflects a focus on neuroscience, disease mechanisms, and preliminary or preprint dissemination platforms. The collected works contribute to understanding molecular and cellular processes relevant to neurobiology, cancer biology, and immune responses.

Best Publications

  • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

    Seija Lehnardt;Leon Massillon;Pamela Follett;Frances E. Jensen

  • Oxidative stress induces apoptosis in embryonic cortical neurons.

    Rajiv R. Ratan;Timothy H. Murphy;Jay M. Baraban

  • Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

    Robert J. Ferrante;James K. Kubilus;Junghee Lee;Hoon Ryu

  • Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

    Sama F Sleiman;Jeffrey Henry;Rami Al-Haddad;Lauretta El Hayek

  • Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

    Megan W. Bourassa;Ishraq Alim;Scott J. Bultman;Rajiv R. Ratan

  • Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease

    Gabriella Gardian;Susan E. Browne;Dong Kug Choi;Peter Klivenyi

  • Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

    Marietta Zille;Saravanan S. Karuppagounder;Yingxin Chen;Peter J. Gough

  • Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.

    Khalequz Zaman;Hoon Ryu;David Hall;Kevin O'Donovan

  • Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.

    Junghee Lee;Hoon Ryu;Robert J. Ferrante;Sidney M. Morris

  • HDAC6 is a target for protection and regeneration following injury in the nervous system

    Mark A. Rivieccio;Camille Brochier;Dianna E. Willis;Breset A. Walker

  • Therapeutic effects of cystamine in a murine model of Huntington's disease.

    Alpaslan Dedeoglu;Alpaslan Dedeoglu;James K. Kubilus;James K. Kubilus;Thomas M. Jeitner;Samantha A. Matson

  • Arginase I and Polyamines Act Downstream from Cyclic AMP in Overcoming Inhibition of Axonal Growth MAG and Myelin In Vitro

    Dongming Cai;Kangwen Deng;Wilfredo Mellado;Junghee Lee

  • Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.

    Savita Khanna;Sashwati Roy;Hoon Ryu;Praveen Bahadduri

  • Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system

    Ambreena Siddiq;Ambreena Siddiq;Issam A. Ayoub;Juan C. Chavez;Juan C. Chavez;Leila Aminova

  • Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

    Gary E. Gibson;Anatoly Starkov;John P. Blass;Rajiv R. Ratan

  • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

    Sandra Camelo;Antonio H. Iglesias;Daehee Hwang;Brice Due

  • Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

    Rajiv R. Ratan;Timothy H. Murphy;Jay M. Baraban

  • Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

    Hoon Ryu;Junghee Lee;Beatrix A. Olofsson;Aziza Mwidau

  • N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

    Saravanan S. Karuppagounder;Lauren Alin;Yingxin Chen;David Brand

  • Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons.

    Hoon Ryu;Junghee Lee;Khalequz Zaman;James Kubilis;James Kubilis

  • Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

    Kuo-I Lin;Swu-Hua Lee;Ramaswamy Narayanan;J. M. Baraban

Frequent Co-Authors

Hoon Ryu
Hoon Ryu Korea Institute of Science and Technology
Junghee Lee
Junghee Lee University of California, Los Angeles
Robert J. Ferrante
Robert J. Ferrante Boston University
Sunghee Cho
Sunghee Cho Cornell University
M. Flint Beal
M. Flint Beal Cornell University
Jay M. Baraban
Jay M. Baraban Johns Hopkins University
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles
Gary E. Gibson
Gary E. Gibson Cornell University
Adam R. Ferguson
Adam R. Ferguson University of California, San Francisco
Michael S. Beattie
Michael S. Beattie University of California, San Francisco

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