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D-Index & Metrics

Neuroscience

D-Index
62
Citations
14657
World Ranking
3512
National Ranking
16

Biology and Biochemistry

D-Index
63
Citations
14943
World Ranking
10172
National Ranking
110

Overview

Hoon Ryu is affiliated with the Korea Institute of Science and Technology in South Korea. Their research primarily focuses on neuroscience, medicine, and biochemistry, genetics and molecular biology. A significant portion of their work covers molecular biology, neurology, and cellular and molecular neuroscience, with important subfields including physiology and biological psychiatry.

The researcher's major scientific topics include neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, and neuroscience and neuropharmacology research. Additional areas of focus are tryptophan and brain disorders, mitochondrial function and pathology, amyotrophic lateral sclerosis research, and studies involving S100 proteins and annexins.

Hoon Ryu has published extensively in several scientific venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Research Square (Research Square)
  • Molecular Neurodegeneration
  • Nature Communications

Notable recent papers by Hoon Ryu feature contributions to understanding neurodegenerative diseases such as Alzheimer's and Parkinson's. These include:

  • Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2− production, 2020, Nature Neuroscience
  • Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease, 2020, Current Biology
  • Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer's disease, 2022, Cell Metabolism
  • Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease, 2020, Aging Cell
  • Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus, 2021, Biological Psychiatry

Throughout their career, Hoon Ryu has collaborated frequently with certain researchers, including Seung Jae Hyeon, C. Justin Lee, Junghee Lee, Uiyeol Park, and Eun Mi Hwang.

Best Publications

  • Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

    Robert J. Ferrante;James K. Kubilus;Junghee Lee;Hoon Ryu

  • GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

    Seonmi Jo;Seonmi Jo;Oleg Yarishkin;Yu Jin Hwang;Ye Eun Chun

  • Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease

    Gabriella Gardian;Susan E. Browne;Dong Kug Choi;Peter Klivenyi

  • Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.

    Khalequz Zaman;Hoon Ryu;David Hall;Kevin O'Donovan

  • Sodium phenylbutyrate prolongs survival and regulates expression of anti‐apoptotic genes in transgenic amyotrophic lateral sclerosis mice

    Hoon Ryu;Karen Smith;Sandra I. Camelo;Isabel Carreras

  • Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.

    Junghee Lee;Hoon Ryu;Robert J. Ferrante;Sidney M. Morris

  • Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.

    Savita Khanna;Sashwati Roy;Hoon Ryu;Praveen Bahadduri

  • miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model

    Soon-Tae Lee;Kon Chu;Keun-Hwa Jung;Jin Hee Kim

  • ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

    Hoon Ryu;Junghee Lee;Sean W. Hagerty;Byoung Yul Soh

  • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

    Sandra Camelo;Antonio H. Iglesias;Daehee Hwang;Brice Due

  • Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

    Hoon Ryu;Junghee Lee;Beatrix A. Olofsson;Aziza Mwidau

  • Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons.

    Hoon Ryu;Junghee Lee;Khalequz Zaman;James Kubilis;James Kubilis

  • ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.

    Takao Ohtsuka;Hoon Ryu;Yohji A. Minamishima;Salvador Macip

  • Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice.

    Edward C. Stack;James K. Kubilus;James K. Kubilus;Karen Smith;Karen Smith;Kerry Cormier;Kerry Cormier

  • Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2-production

    Heejung Chun;Hyeonjoo Im;You Jung Kang;Yunha Kim

  • Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

    Ann C. McKee;Isabel Carreras;Isabel Carreras;Lokman Hossain;Hoon Ryu;Hoon Ryu

  • Mitochondrial Cyclic AMP Response Element-binding Protein (CREB) Mediates Mitochondrial Gene Expression and Neuronal Survival

    Junghee Lee;Junghee Lee;Chun Hyung Kim;David K. Simon;Lyaylya R. Aminova

  • Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease

    Robert J. Ferrante;Hoon Ryu;Hoon Ryu;James K. Kubilus;James K. Kubilus;Santosh D'Mello

  • SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.

    Junghee Lee;Junghee Lee;Yunha Kim;Tian Liu;Yu Jin Hwang

  • IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

    Huikyong Lee;Jee Yeon Noh;Yumin Oh;Youngdoo Kim

  • Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons

    Hoon Ryu;Junghee Lee;Junghee Lee;Soren Impey;Rajiv R. Ratan

Frequent Co-Authors

Junghee Lee
Junghee Lee University of California, Los Angeles
Neil W. Kowall
Neil W. Kowall Boston University
Robert J. Ferrante
Robert J. Ferrante Boston University
Myeong Soo Lee
Myeong Soo Lee Korea University of Science and Technology
Rajiv R. Ratan
Rajiv R. Ratan Cornell University
Hun-Taeg Chung
Hun-Taeg Chung University of Ulsan
Ann C. McKee
Ann C. McKee Boston University
C. Justin Lee
C. Justin Lee Institute for Basic Science
Daesoo Kim
Daesoo Kim Korea Advanced Institute of Science and Technology
Jeong-Sun Seo
Jeong-Sun Seo Seoul National University Bundang Hospital

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