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Chemistry

D-Index
74
Citations
19895
World Ranking
4674
National Ranking
1473

Overview

Peter P. Fu is affiliated with the United States Food and Drug Administration in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions distributed across related subfields including molecular biology, pharmacology, ecology, evolution, behavior and systematics, emergency medicine, and biomedical engineering.

The scientist's work concentrates on several main topics, notably plant toxicity and pharmacological properties, drug-induced hepatotoxicity and protection, botanical research and chemistry, poisoning and overdose treatments, as well as advanced biosensing and bioanalysis techniques. Specific attention is given to the detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids, a group of toxic compounds found in certain herbal medicines and dietary supplements.

Peter P. Fu has published extensively in several academic venues. The most frequent publication platforms include:

  • Journal of Food and Drug Analysis
  • Journal of Environmental Science and Health Part C
  • Chemical Research in Toxicology
  • The FASEB Journal
  • arXiv (Cornell University)

The author's recent notable publications include:

  • "Pyrrolizidine alkaloids - Tumorigenic components in Chinese herbal medicines and dietary supplements", 2020, Journal of Food and Drug Analysis
  • "Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China", 2020, Acta Pharmacologica Sinica
  • "Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements", 2020, Journal of Food and Drug Analysis
  • "Comprehensive investigation and risk study on pyrrolizidine alkaloid contamination in Chinese retail honey", 2020, Environmental Pollution
  • "Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer", 2021, Hepatology

Collaborations are an important aspect of Peter P. Fu's research. Frequent coauthors include:

  • Ge Lin
  • Qingsu Xia
  • Yisheng He
  • Jiang Ma
  • Lin Zhu

Overall, Peter P. Fu's scientific contributions emphasize molecular and pharmacological studies on plant-derived toxic compounds, with a notable focus on pyrrolizidine alkaloids and their effects on human health through hepatotoxicity and tumorigenicity research. Their collaborative work and publications contribute to understanding the risks associated with certain herbal medicines and dietary supplements from a biochemical and toxicological perspective.

Best Publications

  • Mechanisms of nanotoxicity: generation of reactive oxygen species.

    Peter P. Fu;Qingsu Xia;Huey-Min Hwang;Paresh C. Ray

  • Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

    Paresh Chandra Ray;Hongtao Yu;Peter P. Fu

  • Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms.

    Peter P. Fu;Qingsu Xia;Ge Lin;Ming W. Chou

  • The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials.

    Jun Jie Yin;Fang Lao;Peter P. Fu;Wayne G. Wamer

  • Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list.

    Jian Yan;Lei Wang;Peter P Fu;Hongtao Yu

  • Dehydrogenation of polycyclic hydroaromatic compounds

    Peter P. Fu;Ronald G. Harvey

  • Initial Oxidation Products in the Metabolism of Pyrene, Anthracene, Fluorene, and Dibenzothiophene by the White Rot Fungus Pleurotus ostreatus.

    L Bezalel;Y Hadar;P P Fu;J P Freeman

  • Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damage.

    Jun-Jie Yin;Jun Liu;Marilyn Ehrenshaft;Joan E. Roberts

  • Characterization, identification of ambient air and road dust polycyclic aromatic hydrocarbons in central Taiwan, Taichung

    Guor-Cheng Fang;Cheng-Nan Chang;Yuh-Shen Wu;Peter Pi-Cheng Fu

  • Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage.

    Peter P. Fu;Qingsu Xia;Xin Sun;Hongtao Yu

  • Metabolism of nitro-polycyclic aromatic hydrocarbons.

    Peter P. Fu

  • Degradation of Benzo[a]pyrene by Mycobacterium vanbaalenii PYR-1

    Joanna D. Moody;James P. Freeman;Peter P. Fu;Carl E. Cerniglia

  • Metabolism of phenanthrene by the white rot fungus Pleurotus ostreatus.

    L Bezalel;Y Hadar;P P Fu;J P Freeman

  • Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.

    Peter G. Wislocki;Edward S. Bagan;Anthony Y.H. Lu;Kenneth L. Dooley

  • Characterization of particulate, metallic elements of TSP, PM2.5 and PM2.5-10 aerosols at a farm sampling site in Taiwan, Taichung

    Guor-Cheng Fang;Cheng-Nan Chang;Chia-Chium Chu;Yuh-Shen Wu

  • Metabolic Activation of Pyrrolizidine Alkaloids: Insights into the Structural and Enzymatic Basis

    Jianqing Ruan;Mengbi Yang;Peter Fu;Yang Ye;Yang Ye

  • Theranostic nanomedicine for cancer detection and treatment.

    Zhen Fan;Peter P. Fu;Hongtao Yu;Paresh C. Ray

  • Enzyme-like activity of nanomaterials.

    Weiwei He;Wayne Wamer;Qingsu Xia;Jun-jie Yin

  • Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger.

    Jun Jie Yin;Fang Lao;Jie Meng;Peter P. Fu

  • Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

    Badri G. Modi;Jason Neustadter;Elisa Binda;Elisa Binda;Julia Lewis

  • Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo.

    Ya-Chen Yang;Jian Yan;Daniel R. Doerge;Po-Cheun Chan

Frequent Co-Authors

Ge Lin
Ge Lin Chinese University of Hong Kong
Robert H. Heflich
Robert H. Heflich United States Food and Drug Administration
Jun-Jie Yin
Jun-Jie Yin US Food and Drug Administration
Guor-Cheng Fang
Guor-Cheng Fang Hungkuang University
Frederick A. Beland
Frederick A. Beland National Center for Toxicological Research
Ronald G. Harvey
Ronald G. Harvey University of Chicago
Carl E. Cerniglia
Carl E. Cerniglia United States Food and Drug Administration
Daniel R. Doerge
Daniel R. Doerge United States Food and Drug Administration
Lei Guo
Lei Guo National Center for Toxicological Research
Paresh Chandra Ray
Paresh Chandra Ray Jackson State University

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