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D-Index & Metrics

Molecular Biology

D-Index
60
Citations
10747
World Ranking
1982
National Ranking
985

Overview

Robert H. Heflich is affiliated with the United States Food and Drug Administration in the United States. Their scholarly work intersects several disciplines within biochemistry, genetics, and molecular biology, contributing significantly to cancer research, molecular biology, health, toxicology, mutagenesis, biochemistry, and physiology.

Their research focuses notably on carcinogens and genotoxicity assessment, molecular biology techniques and applications, CRISPR and genetic engineering, sulfur compounds in biology, water treatment and disinfection, DNA repair mechanisms, and polyamine metabolism and applications.

Frequent coauthors collaborating with Robert H. Heflich include Aisar Atrakchi, Xiaoqing Guo, Timothy J. McGovern, Nan Mei, and Xuefei Cao. These collaborations have resulted in multiple publications appearing in various scientific venues.

The most common publication venues for their work are:

  • Environmental and Molecular Mutagenesis
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  • Regulatory Toxicology and Pharmacology
  • Archives of Toxicology
  • Toxicological Sciences

Selected recent papers authored or coauthored by Robert H. Heflich include:

  • Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives, 2020, In Vitro Cellular & Developmental Biology - Animal
  • Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT), 2020, Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  • Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment, 2023, Mutation Research/Reviews in Mutation Research
  • Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing, 2021, Environmental and Molecular Mutagenesis
  • Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing, 2023, Nature Reviews Drug Discovery

Best Publications

  • Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

    Robert H. Heflich;Robin E. Neft

  • Arylamine-DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis.

    Frederick A. Beland;David T. Beranek;Kenneth L. Dooley;Robert H. Heflich

  • Formation of DNA Adducts in Vitro and in Salmonella typhimurium upon Metabolic Reduction of the Environmental Mutagen 1-Nitropyrene

    Paul C. Howard;Robert H. Heflich;Frederick E. Evans;Frederick A. Beland

  • Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

    Yan Li;David H. Chen;Jian Yan;Ying Chen

  • Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat.

    Daishiro Miura;Vasily N. Dobrovolsky;Yoshinori Kasahara;Yasuhiro Katsuura

  • Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract.

    F Rafil;W Franklin;R H Heflich;C E Cerniglia

  • Genotypic selection methods for the direct analysis of point mutations.

    Barbara L Parsons;Robert H Heflich

  • Accumulation of point mutations in mitochondrial DNA of aging mice

    Magomed Khaidakov;Robert H Heflich;Mugimane G Manjanatha;Meagan B Myers;Meagan B Myers

  • The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment

    Vasily N. Dobrovolsky;Daishiro Miura;Robert H. Heflich;Stephen D. Dertinger

  • DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.

    Nan Mei;Volker M. Arlt;David H. Phillips;Robert H. Heflich

  • Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.

    S.J Culp;F.A Beland;R.H Heflich;R.W Benson

  • The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

    B. Bhaskar Gollapudi;Anthony M. Lynch;Robert H. Heflich;Stephen D. Dertinger

  • In vivo transgenic mutation assays.

    Véronique Thybaud;Stephen Dean;Takehiko Nohmi;Johan de Boer

  • Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests: I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards

    D.J. Tweats;D. Blakey;R.H. Heflich;A. Jacobs

  • Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents.

    R.H. Heflich;D.T. Beranek;R.L. Kodell;S.M. Morris

  • Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea

    Daishiro Miura;Vasily N. Dobrovolsky;Takafumi Kimoto;Yoshinori Kasahara

  • The orientation of the nitro substituent predicts the direct-acting bacterial mutagenicity of nitrated polycyclic aromatic hydrocarbons

    Peter P. Fu;Ming W. Chou;Dwight W. Miller;Gail L. White

  • Fungal metabolism and detoxification of polycyclic aromatic hydrocarbons.

    Carl E. Cerniglia;Gail L. White;Robert H. Heflich

  • Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

    G.E. Johnson;L.G. Soeteman-Hernández;B.B. Gollapudi;O.G. Bodger

  • Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA.

    Frederick A. Beland;Nancy F. Fullerton;Robert H. Heflich

Frequent Co-Authors

Frederick A. Beland
Frederick A. Beland National Center for Toxicological Research
Peter P. Fu
Peter P. Fu United States Food and Drug Administration
Daniel A. Casciano
Daniel A. Casciano University of Arkansas at Little Rock
Carl E. Cerniglia
Carl E. Cerniglia United States Food and Drug Administration
Martha M. Moore
Martha M. Moore National Center for Toxicological Research
Stephen D. Dertinger
Stephen D. Dertinger University of Rochester
Daniel R. Doerge
Daniel R. Doerge United States Food and Drug Administration
David Kirkland
David Kirkland Covance (United States)
Takehiko Nohmi
Takehiko Nohmi Gifu University
Fred F. Kadlubar
Fred F. Kadlubar United States Food and Drug Administration

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