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Biology and Biochemistry

D-Index
48
Citations
9146
World Ranking
18346
National Ranking
1441

Overview

Tom J. Little is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to subfields such as molecular biology, aging, genetics, social psychology, and ecology.

The scientist's work covers a range of topics including epigenetics and DNA methylation, genetics, aging, and longevity in model organisms, genetics and neurodevelopmental disorders, neuroendocrine regulation and behavior, physiological and biochemical adaptations, zebrafish biomedical research applications, and chromosomal and genetic variations.

They have published extensively, with notable recent papers including:

  • Universal DNA methylation age across mammalian tissues, 2023, Nature Aging
  • Universal DNA methylation age across mammalian tissues, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna, 2021, Epigenetics & Chromatin
  • Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna, 2022, Molecular Biology and Evolution
  • Epigenetic age estimation of wild mice using faecal samples, 2024, Molecular Ecology

Their frequent co-authors include Jack Hearn, Zhe Fei, Amin Haghani, Todd R. Robeck, and Joseph A. Zoller.

Tom J. Little has published multiple papers in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Aging, Molecular Ecology, Epigenetics & Chromatin, and Molecular Biology and Evolution.

Best Publications

  • Genetic variation in a host-parasite association: potential for coevolution and frequency-dependent selection.

    Hans Joachim Carius;Tom J. Little;Dieter Ebert

  • Immunity in a variable world.

    Brian P. Lazzaro;Thomas Little

  • Maternal Transfer of Strain-Specific Immunity in an Invertebrate

    Tom J Little;Benjamin O'Connor;Nick Colegrave;Kathryn Watt

  • Natural selection drives extremely rapid evolution in antiviral RNAi genes.

    Darren J. Obbard;Francis M. Jiggins;Daniel L. Halligan;Tom J. Little

  • Invertebrate immunity and the limits of mechanistic immunology.

    Tom J Little;Dan Hultmark;Andrew F Read

  • Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload.

    Jonathan Folland;Ben Leach;Tom Little;Kate Hawker

  • Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology

    Andrea Linn Graham;Andrea Linn Graham;David M. Shuker;Laura C. Pollitt;Stuart K.J.R. Auld

  • Ecological and evolutionary implications of immunological priming in invertebrates

    Tom J. Little;Alex R. Kraaijeveld

  • HOST-PARASITE AND GENOTYPE-BY-ENVIRONMENT INTERACTIONS: TEMPERATURE MODIFIES POTENTIAL FOR SELECTION BY A STERILIZING PATHOGEN

    Suzanne E. Mitchell;Emily S. Rogers;Tom J. Little;Andrew F. Read

  • The evolution of virulence when parasites cause host castration and gigantism

    Dieter Ebert;Hans Joachim Carius;Tom Little;Ellen Decaestecker

  • The Coevolution of Virulence: Tolerance in Perspective

    Tom J. Little;David M. Shuker;Nick Colegrave;Troy Day

  • Empirical support for optimal virulence in a castrating parasite.

    Knut Helge Jensen;Thomas Little;Arne Skorping;Dieter Ebert

  • Deforestation and Vectorial Capacity of Anopheles gambiae Giles Mosquitoes in Malaria Transmission, Kenya

    Yaw A. Afrane;Thomas Little;Bernard W. Lawson;Andrew K. Githeko

  • The Dscam Homologue of the Crustacean Daphnia Is Diversified by Alternative Splicing Like in Insects

    Daniela Brites;Seanna McTaggart;Krystalynne Morris;Jobriah Anderson

  • Strength training: Isometric training at a range of joint angles versus dynamic training

    Jonathan P. Folland;Kate Hawker;Ben Leach;Thomas Little

  • PARASITE-HOST SPECIFICITY: EXPERIMENTAL STUDIES ON THE BASIS OF PARASITE ADAPTATION

    Tom J. Little;Kathryn Watt;Dieter Ebert

  • Daphnia magna transcriptome by RNA-Seq across 12 environmental stressors

    Luisa Orsini;Donald Gilbert;Ram Podicheti;Mieke Jansen

  • The evolutionary significance of parasitism: do parasite‐driven genetic dynamics occur ex silico?

    Thomas Little

  • Parasite-driven genetic change in a natural population of Daphnia.

    Alison B. Duncan;Thomas Little

  • Temperature-dependent costs of parasitism and maintenance of polymorphism under genotype-by-environment interactions.

    P. F. Vale;Martin Stjernman;Martin Stjernman;T. J. Little

Frequent Co-Authors

Dieter Ebert
Dieter Ebert University of Basel
Claus Wedekind
Claus Wedekind University of Lausanne
Francis M. Jiggins
Francis M. Jiggins University of Cambridge
Paul D. N. Hebert
Paul D. N. Hebert University of Guelph
Andrew F. Read
Andrew F. Read Pennsylvania State University
John K. Colbourne
John K. Colbourne University of Birmingham
Stuart A. West
Stuart A. West University of Oxford
Mark Blaxter
Mark Blaxter Wellcome Sanger Institute
Guiyun Yan
Guiyun Yan University of California, Irvine

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