His scientific interests lie mostly in Genetic variation, Genetics, Natural selection, Pasteuria ramosa and Ecology. Tom J. Little combines subjects such as Red Queen hypothesis, Host and Genetic diversity with his study of Genetic variation. His work on Effector expands to the thematically related Genetics.
He has researched Natural selection in several fields, including RNA, Drosophila melanogaster and Innate immune system. His studies in Pasteuria ramosa integrate themes in fields like Acquired immune system, Pathogen, Secondary infection and Phenotypic plasticity. His Ecology study combines topics in areas such as Evolutionary biology, Zoology, Anopheles gambiae, Immune system and Malaria transmission.
Tom J. Little mainly investigates Genetics, Pasteuria ramosa, Ecology, Zoology and Genetic variation. His Genetics research includes themes of Evolutionary biology and Natural selection. His Pasteuria ramosa study incorporates themes from Host, Immune system and Microbiology.
While the research belongs to areas of Ecology, he spends his time largely on the problem of Polyploid, intersecting his research to questions surrounding Arctic and Apomixis. His work deals with themes such as Fecundity, Juvenile, Sexual reproduction and Parasitism, which intersect with Zoology. His research in Genetic variation intersects with topics in Genetic diversity, Genetic variability, Microparasite, Linkage disequilibrium and Red Queen hypothesis.
Tom J. Little mostly deals with Genetics, DNA methylation, Epigenetics, Gene and Maternal effect. His Genetics research includes elements of Diverse population and Population genetics. His Epigenetics study incorporates themes from Methylation and Ageing.
His study of Gene expression is a part of Gene. His work focuses on many connections between RNA-Seq and other disciplines, such as Metagenomics, that overlap with his field of interest in Genome and Evolutionary biology. His Evolutionary biology research is multidisciplinary, incorporating elements of Organism, Pathogen and Age structure.
Tom J. Little mainly focuses on Maternal effect, Genome, Evolutionary biology, Age structured and Disease. He integrates several fields in his works, including Maternal effect, Mechanism, Crowding, Host, Immune system and Toxicology. Within the field of Gene and Genetics he studies Genome.
His work deals with themes such as Range, RNA-Seq, Population genetics, Genetic diversity and Mitochondrial DNA, which intersect with Evolutionary biology. His Age structured research is multidisciplinary, relying on both Ecology, Senescence and Epidemiology.
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Genetic variation in a host-parasite association: potential for coevolution and frequency-dependent selection.
Hans Joachim Carius;Tom J. Little;Dieter Ebert.
Evolution (2001)
Immunity in a variable world.
Brian P. Lazzaro;Thomas Little.
Philosophical Transactions of the Royal Society B (2009)
Maternal Transfer of Strain-Specific Immunity in an Invertebrate
Tom J Little;Benjamin O'Connor;Nick Colegrave;Kathryn Watt.
Current Biology (2003)
Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload.
Jonathan Folland;Ben Leach;Tom Little;Kate Hawker.
Experimental Physiology (2000)
Natural selection drives extremely rapid evolution in antiviral RNAi genes.
Darren J. Obbard;Francis M. Jiggins;Daniel L. Halligan;Tom J. Little.
Current Biology (2006)
Invertebrate immunity and the limits of mechanistic immunology.
Tom J Little;Dan Hultmark;Andrew F Read.
Nature Immunology (2005)
HOST-PARASITE AND GENOTYPE-BY-ENVIRONMENT INTERACTIONS: TEMPERATURE MODIFIES POTENTIAL FOR SELECTION BY A STERILIZING PATHOGEN
Suzanne E. Mitchell;Emily S. Rogers;Tom J. Little;Andrew F. Read.
Evolution (2005)
Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology
Andrea Linn Graham;Andrea Linn Graham;David M. Shuker;Laura C. Pollitt;Stuart K.J.R. Auld.
Functional Ecology (2011)
Ecological and evolutionary implications of immunological priming in invertebrates
Tom J. Little;Alex R. Kraaijeveld.
Trends in Ecology and Evolution (2004)
The evolution of virulence when parasites cause host castration and gigantism
Dieter Ebert;Hans Joachim Carius;Tom Little;Ellen Decaestecker.
The American Naturalist (2004)
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