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Biology and Biochemistry

D-Index
74
Citations
18647
World Ranking
5622
National Ranking
405

Overview

Thomas Tüting is affiliated with Otto-von-Guericke University Magdeburg in Germany. Their research predominantly spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. The primary subfields of study include Oncology, Immunology, Molecular Biology, Genetics, and Dermatology.

The main topics covered in Thomas Tüting's work focus on several critical areas within cancer and immunology research:

  • Cutaneous Melanoma Detection and Management
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Melanoma and MAPK Pathways
  • CAR-T Cell Therapy Research
  • Immune Cell Function and Interaction
  • CRISPR and Genetic Engineering

Among recent publications, the following papers demonstrate areas of active research:

  • "CD4+ T Cell-Induced Inflammatory Cell Death Controls Immune-Evasive Tumours," 2023, published in Nature
  • "Prognosis of Patients With Primary Melanoma Stage I and II According to American Joint Committee on Cancer Version 8 Validated in Two Independent Cohorts: Implications for Adjuvant Treatment," 2022, Journal of Clinical Oncology
  • "Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma," 2020, Immunity
  • "Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts," 2020, Journal of Clinical Oncology
  • "N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy," 2022, Gastroenterology

Frequent collaboration characterizes Thomas Tüting's research activities. The most common co-authors include:

  • Miriam Mengoni
  • Evelyn Gaffal
  • Andreas Braun
  • Dirk Schadendorf
  • Christoffer Gebhardt

The venues where Thomas Tüting regularly publishes involve specialized journals that reflect the focus on dermatology, oncology, and cancer research:

  • JDDG Journal der Deutschen Dermatologischen Gesellschaft
  • European Journal of Cancer
  • Cancer Research
  • Nature
  • Journal of Clinical Oncology

Best Publications

  • Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

    Antonella Sistigu;Takahiro Yamazaki;Erika Vacchelli;Kariman Chaba

  • Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

    Tobias Bald;Thomas Quast;Jennifer Landsberg;Meri Rogava

  • Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

    Jennifer Landsberg;Judith Kohlmeyer;Marcel Renn;Tobias Bald

  • A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection.

    Helmut Jonuleit;Andrea Giesecke‐Tuettenberg;Thomas Tüting;Beatrice Thurner‐Schuler

  • 5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

    Poeck H;Besch R;Maihoefer C;Maihoefer C;Renn M

  • Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

    Nadine Gehrke;Christina Mertens;Thomas Zillinger;Jörg Wenzel

  • Attenuation of allergic contact dermatitis through the endocannabinoid system

    Meliha Karsak;Evelyn Gaffal;Rahul Date;Lihua Wang-Eckhardt

  • The experimental power of FR900359 to study Gq-regulated biological processes

    Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala

  • Diagnostic Performance of Whole Body Dual Modality 18F-FDG PET/CT Imaging for N- and M-Staging of Malignant Melanoma: Experience With 250 Consecutive Patients

    Michael J. Reinhardt;Alexius Y. Joe;Ursula Jaeger;Andrea Huber

  • Tissue-resident memory CD8 + T cells promote melanoma-immune equilibrium in skin

    Simone L Park;Anthony Buzzai;Jai Rautela;Jyh Liang Hor

  • Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

    Philipp Koch;Peter Breuer;Michael Peitz;Johannes Jungverdorben

  • Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

    Julia Steitz;Jürgen Brück;Julia Lenz;Jürgen Knop

  • Autologous Human Monocyte-Derived Dendritic Cells Genetically Modified to Express Melanoma Antigens Elicit Primary Cytotoxic T Cell Responses In Vitro: Enhancement by Cotransfection of Genes Encoding the Th1-Biasing Cytokines IL-12 and IFN-α

    Thomas Tüting;Cara C. Wilson;Dina M. Martin;Yvette L. Kasamon

  • Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

    Michael Hölzel;Anton Bovier;Thomas Tüting

  • Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

    Tobias Bald;Jennifer Landsberg;Dorys Lopez-Ramos;Marcel Renn

  • Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

    Nicole Glodde;Nicole Glodde;Tobias Bald;Tobias Bald;Tobias Bald;Debby van den Boorn-Konijnenberg;Kyohei Nakamura

  • Enhanced type I interferon signalling promotes Th1‐biased inflammation in cutaneous lupus erythematosus

    Joerg Wenzel;Eva Wörenkämper;Silke Freutel;Stefanie Henze

  • Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells

    Ronald Backer;Timo Schwandt;Mascha Greuter;Marije Oosting

  • Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

    Damià Tormo;Agnieszka Chęcińska;Direna Alonso-Curbelo;Eva Pérez-Guijarro

  • Attenuation of allergic contact dermatitis through the endocannabinoid system.

    Meliha Karsak;Evelyn Gaffal;Wang-Eckhardt, Lihua Date, Rahul;Petrosino, Stefania Rehnelt, Jennifer

Frequent Co-Authors

Walter J. Storkus
Walter J. Storkus University of Pittsburgh
Michael T. Lotze
Michael T. Lotze University of Pittsburgh
Jürgen Knop
Jürgen Knop Johannes Gutenberg University of Mainz
Richard A. Scolyer
Richard A. Scolyer Royal Prince Alfred Hospital
Andrea Gambotto
Andrea Gambotto University of Pittsburgh
Alexander Enk
Alexander Enk Heidelberg University
Gunther Hartmann
Gunther Hartmann University Hospital Bonn
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Jochen Utikal
Jochen Utikal German Cancer Research Center
Veit Hornung
Veit Hornung Ludwig-Maximilians-Universität München

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