World's Best Scientists 2026 revealed!

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Immunology

D-Index
93
Citations
31911
World Ranking
969
National Ranking
59

Medicine

D-Index
93
Citations
31933
World Ranking
10889
National Ranking
592

Overview

Percy A. Knolle is affiliated with the Technical University of Munich in Germany. Their research spans several domains within medicine and biology, focusing particularly on immunology, infectious diseases, epidemiology, hepatology, and molecular biology. The scientist has contributed extensively to both fundamental and clinical research areas.

Their work frequently appears in prominent publication venues, reflecting a consistent publication record in the following journals and platforms:

  • Journal of Hepatology
  • Zeitschrift für Gastroenterologie
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Immunology

Key topics central to Knolle's investigations include immune cell function and interaction, SARS-CoV-2 and COVID-19 research, hepatitis B virus studies, liver disease diagnosis and treatment, hepatitis C virus research, COVID-19 clinical research studies, and diabetes along with associated disorders.

Recent notable publications authored or co-authored by Knolle cover a range of impactful biomedical subjects:

  • "Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH," 2021, Nature
  • "Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity," 2021, Nature Metabolism
  • "Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern," 2022, Nature Medicine
  • "Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal," 2020, Nature Immunology
  • "Inhibition of LTβR signalling activates WNT-induced regeneration in lung," 2020, Nature

Knolle has frequently collaborated with other researchers, including Ulrike Protzer, Dirk Wohlleber, Sainitin Donakonda, Michael Dudek, and Mathias Heikenwälder. These collaborations have resulted in numerous co-authored works, suggesting an integrated network within their research community.

The scientist's primary fields of study center around medicine with a substantial focus on immunology and microbiology. Within subfields, a strong concentration on immunology is evident, followed by infectious diseases, epidemiology, hepatology, and molecular biology. This interdisciplinary approach is reflected in the diverse research topics and high-impact publications.

Best Publications

  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Dominik Pfister;Dominik Pfister;Nicolás Gonzalo Núñez;Roser Pinyol;Olivier Govaere

  • Antigen-presenting cell function in the tolerogenic liver environment.

    Angus W Thomson;Percy A Knolle

  • Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

    Christoph Roderburg;Gerd-Willem Urban;Kira Bettermann;Mihael Vucur

  • Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance.

    Andreas Limmer;Jutta Ohl;Christian Kurts;Hans-Gustaf Ljunggren

  • Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation

    Sven Burgdorf;Andreas Kautz;Volker Böhnert;Percy A. Knolle

  • TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

    Francesca Alfei;Kristiyan Kanev;Maike Hofmann;Ming Wu

  • Local control of the immune response in the liver.

    Percy A. Knolle;Guido Gerken

  • Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

    Monika Julia Wolf;Arlind Adili;Kira Piotrowitz;Zeinab Abdullah

  • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

    Marc Beyer;Matthias Kochanek;Matthias Kochanek;Kamruz Darabi;Kamruz Darabi;Alexey Popov;Alexey Popov

  • Living in the liver: hepatic infections

    Ulrike Protzer;Mala K. Maini;Percy A. Knolle

  • NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

    Franz Bauernfeind;Anna Rieger;Frank A. Schildberg;Percy A. Knolle

  • Cross-priming in health and disease.

    Christian Kurts;Bruce W. S. Robinson;Percy A. Knolle

  • Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

    Unknown

  • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

    R Duchmann;E Schmitt;P Knolle;K H Meyer zum Büschenfelde

  • High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

    Dominic Francis De Nardo;Larisa I Labzin;Hajime Kono;Reiko Seki

  • Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern

    Unknown

  • Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASH

    Michael Dudek;Dominik Pfister;Sainitin Donakonda;Pamela Filpe

  • A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

    Arman A Bashirova;Teunis B.H. Geijtenbeek;Gerard C.F. van Duijnhoven;Sandra J. van Vliet

  • The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

    Luisa Klotz;Sven Burgdorf;Indra Dani;Kaoru Saijo

  • Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.

    Percy A. Knolle;Edgar Schmitt;Shenciu Jin;Tieno Germann

  • In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma

    Marc Beyer;Matthias Kochanek;Matthias Kochanek;Matthias Kochanek;Thomas Giese;Thomas Giese;Thomas Giese;Elmar Endl;Elmar Endl;Elmar Endl

  • T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

    R Duchmann;E May;M Heike;P Knolle

  • Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.

    Linda Diehl;Anna Schurich;Regina Grochtmann;Silke Hegenbarth

Frequent Co-Authors

Christian Kurts
Christian Kurts University of Bonn
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Ulrike Protzer
Ulrike Protzer Technical University of Munich
Joachim L. Schultze
Joachim L. Schultze University of Bonn
Edgar Schmitt
Edgar Schmitt Johannes Gutenberg University of Mainz
Luisa Klotz
Luisa Klotz University Hospital Münster
K.-H. Meyer zum Büschenfelde
K.-H. Meyer zum Büschenfelde Johannes Gutenberg University of Mainz
Wolfgang Kastenmüller
Wolfgang Kastenmüller University of Würzburg
Jonel Trebicka
Jonel Trebicka University Hospital of Münster
Eicke Latz
Eicke Latz German Rheumatism Research Centre

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