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Immunology

D-Index
86
Citations
31357
World Ranking
1243
National Ranking
80

Medicine

D-Index
86
Citations
31393
World Ranking
13994
National Ranking
743

Overview

Edgar Schmitt is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research encompasses various aspects of immunology, molecular biology, and biochemistry, with particular emphasis on glycosylation, immune cell function, and molecular mechanisms involved in immune responses.

Their publications span multiple fields of study, including:

  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader categories, Schmitt has contributed to several subfields, notably:

  • Immunology
  • Molecular Biology
  • Organic Chemistry
  • Radiology, Nuclear Medicine and Imaging
  • Physiology

The main topics addressed in their work cover:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction
  • IL-33, ST2, and ILC Pathways
  • Immunotherapy and Immune Responses
  • Mast cells and histamine

Recent publications authored or co-authored by Schmitt include:

  • "MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response" (2023), published in the Journal of the American Chemical Society
  • "The Development of Vaccines from Synthetic Tumor-Associated Mucin Glycopeptides and their Glycosylation-Dependent Immune Response" (2021), published in The Chemical Record
  • "In Activated Murine Mast Cells, NFATc2 Is Critical for the Production of Autocrine IL-3, Thereby Promoting the Expression of IL-9" (2020), published in The Journal of Immunology
  • "Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host" (2023), published in Cellular and Molecular Life Sciences
  • "CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production" (2025), published in Frontiers in Immunology

Schmitt frequently collaborates with other researchers, including:

  • Natascha Stergiou
  • Tobias Bopp
  • Adele Gabba
  • Riem Attariya
  • Moritz Urschbach

The frequent publication venues reflect the interdisciplinary nature of Schmitt's work and include:

  • Journal of the American Chemical Society
  • The Chemical Record
  • The Journal of Immunology
  • Cellular and Molecular Life Sciences
  • Frontiers in Immunology

Best Publications

  • Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

    Helmut Jonuleit;Edgar Schmitt;Gerold Schuler;Jürgen Knop

  • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

    Helmut Jonuleit;Edgar Schmitt;Michael Stassen;Andrea Tuettenberg

  • Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

    Helmut Jonuleit;Ulrich Kühn;Gabriele Müller;Kerstin Steinbrink

  • Epigenetic Control of the foxp3 Locus in Regulatory T Cells

    Stefan Floess;Jennifer Freyer;Christiane Siewert;Udo Baron

  • Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

    Tobias Bopp;Christian Becker;Matthias Klein;Stefan Klein-Heßling

  • Infectious Tolerance: Human CD25+ Regulatory T Cells Convey Suppressor Activity to Conventional CD4+ T Helper Cells

    Helmut Jonuleit;Edgar Schmitt;Hacer Kakirman;Michael Stassen

  • Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

    Valérie Staudt;Evita Bothur;Matthias Klein;Karen Lingnau

  • Dendritic cells as a tool to induce anergic and regulatory T cells.

    Helmut Jonuleit;Edgar Schmitt;Kerstin Steinbrink;Alexander H Enk

  • The Regulatory T Cell Family: Distinct Subsets and their Interrelations

    Helmut Jonuleit;Edgar Schmitt

  • Immature, but not inactive: the tolerogenic function of immature dendritic cells

    Karsten Mahnke;Edgar Schmitt;Laura Bonifaz;Alexander H Enk

  • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

    R Duchmann;E Schmitt;P Knolle;K H Meyer zum Büschenfelde

  • Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo.

    Tieno Germann;Martina Bongartz;Henryka Dlugonska;Henry Hess

  • IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes

    K Barbulescu;C Becker;J F Schlaak;E Schmitt

  • The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

    Frank Mattner;Susanne Fischer;Stefanie Guckes;Shenchu Jin

  • Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.

    Toszka Bohn;Steffen Rapp;Natascha Luther;Matthias Klein

  • T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta.

    Edgar Schmitt;Petra Hoehn;Christoph Huels;Sigrid Goedert

  • Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.

    Percy A. Knolle;Edgar Schmitt;Shenciu Jin;Tieno Germann

  • The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

    Aysefa Doganci;Tatjana Eigenbrod;Norbert Krug;George T. De Sanctis

  • Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC- derived IL-18 enhances IL-12-dependent Th1 development

    Sabine Stoll;Helmut Jonuleit;Edgar Schmitt;Gabriele Müller

  • Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9).

    Lothar Hültner;Catherine Druez;Jochen Moeller;Catherine Uyttenhove

  • IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.

    E Schmitt;T. Germann;S. Goedert;P. Hoehn

Frequent Co-Authors

Tobias Bopp
Tobias Bopp Johannes Gutenberg University of Mainz
Helmut Jonuleit
Helmut Jonuleit Johannes Gutenberg University of Mainz
Hansjörg Schild
Hansjörg Schild Johannes Gutenberg University of Mainz
Horst Kunz
Horst Kunz Johannes Gutenberg University of Mainz
Percy A. Knolle
Percy A. Knolle Technical University of Munich
Jürgen Knop
Jürgen Knop Johannes Gutenberg University of Mainz
Edgar Serfling
Edgar Serfling University of Würzburg
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Peter R. Galle
Peter R. Galle Johannes Gutenberg University of Mainz
Christian Taube
Christian Taube Johannes Gutenberg University of Mainz

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