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Biology and Biochemistry

D-Index
61
Citations
12284
World Ranking
11433
National Ranking
4939

Overview

Paul M. Thomas is affiliated with Northwestern University in the United States. Their research spans multiple interdisciplinary fields, focusing primarily on biochemistry, genetics, and molecular biology, with significant contributions in chemistry as well.

The scientist's main subfields of study include molecular biology, spectroscopy, pharmacology, computational mechanics, and inorganic chemistry. Their work extensively addresses advanced proteomics techniques and applications, mass spectrometry techniques, biomedical text mining and ontologies, genomics and phylogenetic studies, epigenetics and DNA methylation, cancer-related gene regulation, and RNA modifications related to cancer.

Paul M. Thomas has published in several scientific venues, frequently contributing to:

  • Angewandte Chemie International Edition
  • Biochemistry
  • Journal of Proteome Research
  • Angewandte Chemie
  • Science

Some of the recent publications associated with their research are:

  • The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells, 2022, Science
  • NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle, 2020, Nature Communications
  • The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing, 2020, Nature Cancer
  • Deeper Protein Identification Using Field Asymmetric Ion Mobility Spectrometry in Top-Down Proteomics, 2021, Analytical Chemistry
  • Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds, 2020, mBio

Throughout their career, Paul M. Thomas has collaborated frequently with other researchers. The most common co-authors include:

  • Neil L. Kelleher
  • Ryan T. Fellers
  • Jeannie M. Camarillo
  • Richard D. LeDuc
  • Joseph B. Greer

Best Publications

  • How many human proteoforms are there

    Ruedi Aebersold;Jeffrey N. Agar;I. Jonathan Amster;Mark S. Baker

  • Mapping intact protein isoforms in discovery mode using top-down proteomics

    John C. Tran;Leonid Zamdborg;Dorothy R. Ahlf;Dorothy R. Ahlf;Ji Eun Lee;Ji Eun Lee

  • The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

    Eva Martinez-Garcia;Relja Popovic;Dong Joon Min;Steve M.M. Sweet

  • Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation

    Jared B. Shaw;Wenzong Li;Dustin D. Holden;Yan Zhang

  • Loss of BAP1 function leads to EZH2-dependent transformation.

    Lindsay M. Lafave;Wendy Béguelin;Richard Koche;Matt Teater

  • Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

    Amanda L. McClerren;Lisa E. Cooper;Chao Quan;Paul P. Thomas

  • Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process

    Paul M. Thomas;Gregory D. Foster

  • ProSight Lite: Graphical software to analyze top-down mass spectrometry data

    Ryan T. Fellers;Joseph B. Greer;Bryan P. Early;Xiang Yu

  • The vermiform appendix impacts the risk of developing Parkinson’s disease

    Bryan A. Killinger;Zachary Madaj;Jacek W. Sikora;Nolwen Rey;Nolwen Rey

  • Deconstruction of iterative multidomain polyketide synthase function.

    Jason M. Crawford;Paul M. Thomas;Jonathan R. Scheerer;Anna L. Vagstad

  • On the Scalability and Requirements of Whole Protein Mass Spectrometry

    Philip D. Compton;Leonid Zamdborg;Paul M. Thomas;Neil L. Kelleher

  • Identification and Quantification of Proteoforms by Mass Spectrometry.

    Leah V. Schaffer;Robert J. Millikin;Rachel M. Miller;Lissa C. Anderson

  • Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids

    Rey W. Martin;Benjamin J. Des Soye;Yong Chan Kwon;Jennifer Kay

  • Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

    Luca Fornelli;Eugen Damoc;Paul M. Thomas;Neil L. Kelleher

  • A protease for 'middle-down' proteomics

    Cong Wu;John C Tran;Leonid Zamdborg;Kenneth R Durbin

  • A scalable platform to identify fungal secondary metabolites and their gene clusters

    Kenneth D. Clevenger;Jin Woo Bok;Rosa Ye;Galen P. Miley

  • Large-scale Top-down Proteomics of the Human Proteome: Membrane Proteins, Mitochondria, and Senescence

    Adam D. Catherman;Kenneth R. Durbin;Dorothy R. Ahlf;Bryan P. Early

  • A proteomics approach to discovering natural products and their biosynthetic pathways.

    Stefanie B Bumpus;Bradley S Evans;Paul M Thomas;Ioanna Ntai

  • Top-Down Proteomics on a Chromatographic Time Scale Using Linear Ion Trap Fourier Transform Hybrid Mass Spectrometers

    Bryan A. Parks;Lihua Jiang;Paul M. Thomas;Craig D. Wenger

  • Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

    Yupeng Zheng;Steve M. M. Sweet;Relja Popovic;Eva Martinez-Garcia

Frequent Co-Authors

Neil L. Kelleher
Neil L. Kelleher Northwestern University
Nancy P. Keller
Nancy P. Keller University of Wisconsin–Madison
Ying Ge
Ying Ge University of Wisconsin–Madison
Lloyd M. Smith
Lloyd M. Smith University of Wisconsin–Madison
William W. Metcalf
William W. Metcalf University of Illinois at Urbana-Champaign
Ari Melnick
Ari Melnick Cornell University
Michael C. Jewett
Michael C. Jewett Northwestern University
John D. Crispino
John D. Crispino Northwestern University
Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
Jack A. Gilbert
Jack A. Gilbert University of California, San Diego

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