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Chemistry

D-Index
52
Citations
9402
World Ranking
13539
National Ranking
111

Overview

Michael Gajhede is affiliated with the University of Copenhagen in Denmark. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Oncology, Organic Chemistry, Cellular and Molecular Neuroscience, and Physiology. The scientist's work concentrates on multiple themes related to molecular processes and pharmacology.

The main topics covered in their publications include:

  • Drug Transport and Resistance Mechanisms
  • Genomics, phytochemicals, and oxidative stress
  • Synthesis and Biological Evaluation
  • Neuroscience and Neuropharmacology Research
  • Receptor Mechanisms and Signaling
  • Free Radicals and Antioxidants
  • Lipid Membrane Structure and Behavior

Michael Gajhede has contributed to various academic venues, with frequent publications in:

  • Journal of Medicinal Chemistry
  • Nature Communications
  • FEBS Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells

Their recent papers include the following:

  • Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds, 2021, Journal of Medicinal Chemistry
  • Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery, 2022, Journal of Medicinal Chemistry
  • The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP, 2020, Cells
  • Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism, 2022, Nature Communications
  • Small-molecule modulators of tumor necrosis factor signaling, 2023, Drug Discovery Today

They have collaborated frequently with several coauthors, including:

  • Dilip Narayanan
  • Anders Bach
  • Thomas Boesen
  • Jan Stenvang
  • Cecilie Poulsen

Best Publications

  • Crystal structure of horseradish peroxidase C at 2.15 A resolution.

    Michael Gajhede;David J. Schuller;Anette Henriksen;Andrew T. Smith

  • X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy.

    Michael Gajhede;Peter Osmark;Flemming M. Poulsen;Henrik Ipsen

  • A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils.

    Bente Vestergaard;Minna Groenning;Minna Groenning;Manfred Roessle;Jette S Kastrup

  • The Structures of the Horseradish Peroxidase C-Ferulic Acid Complex and the Ternary Complex with Cyanide Suggest How Peroxidases Oxidize Small Phenolic Substrates

    Anette Henriksen;Andrew T. Smith;Michael Gajhede

  • Dominant Epitopes and Allergic Cross-Reactivity: Complex Formation Between a Fab Fragment of a Monoclonal Murine IgG Antibody and the Major Allergen from Birch Pollen Bet v 1

    Osman Mirza;Anette Henriksen;Henrik Ipsen;Jørgen N. Larsen

  • Structural interactions between horseradish peroxidase C and the substrate benzhydroxamic acid determined by X-ray crystallography.

    Anette Henriksen;David J. Schuller;Kåre Meno;Karen G. Welinder

  • A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Anders Bach;Bettina H. Clausen;Magda Møller;Bente Vestergaard

  • Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.

    Lars Østergaard;Kaare Teilum;Osman Mirza;Ole Mattsson

  • Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family.

    Lars K. Skov;Osman Mirza;Anette Henriksen;Gabrielle Potocki De Montalk

  • Structure of soybean seed coat peroxidase: a plant peroxidase with unusual stability and haem-apoprotein interactions.

    A Henriksen;O Mirza;C Indiani;K Teilum

  • Dominating IgE-Binding Epitope of Bet v 1, the Major Allergen of Birch Pollen, Characterized by X-ray Crystallography and Site-Directed Mutagenesis

    Michael D. Spangfort;Osman Mirza;Henrik Ipsen;R. J. Joost van Neerven

  • Major Venom Allergen of Yellow Jackets, Ves V 5: Structural Characterization of a Pathogenesis-Related Protein Superfamily.

    Anette Henriksen;Te P. King;Osman Mirza;Osman Mirza;Rafaél I. Monsalve

  • Ionotropic glutamate-like receptor δ2 binds d-serine and glycine

    Peter Naur;Kasper B. Hansen;Kasper B. Hansen;Anders S. Kristensen;Shashank M. Dravid

  • Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis Thaliana Peroxidase A2 and Horseradish Peroxidase A2

    K. L. Nielsen;C. Indiani;A. Henriksen;A. Feis

  • Marine alkaloids. 10. Chartelline A: a pentahalogenated alkaloid from the marine bryozoan Chartella papyracea

    Lionel Chevolot;Anne Marie Chevolot;Michael Gajhede;Charles Larsen

  • Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase

    Cécile Albenne;Lars Skov;Osman Asghar Mirza;Michael Gajhede

  • Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis.

    D. Sprogoe;L.A.M. van den Broek;O. Mirza;J.S. Kastrup

  • Structure of Barley Grain Peroxidase Refined at 1.9-Å Resolution: A PLANT PEROXIDASE REVERSIBLY INACTIVATED AT NEUTRAL pH *

    Anette Henriksen;Karen G. Welinder;Michael Gajhede

  • Oligosaccharide and Sucrose Complexes of Amylosucrase. STRUCTURAL IMPLICATIONS FOR THE POLYMERASE ACTIVITY

    Lars K. Skov;Osman Mirza;Desiree Sprogøe;Imran Dar

  • Inhibitors of histone demethylases.

    Brian Lohse;Jesper L. Kristensen;Line H. Kristensen;Karl Agger

Frequent Co-Authors

Carsten Christophersen
Carsten Christophersen University of Copenhagen
Magali Remaud-Simeon
Magali Remaud-Simeon Federal University of Toulouse Midi-Pyrénées
Pierre Monsan
Pierre Monsan Institut National des Sciences Appliquées de Toulouse
Vladimir Berezin
Vladimir Berezin University of Copenhagen
Elisabeth Bock
Elisabeth Bock University of Copenhagen
Karen G. Welinder
Karen G. Welinder Aalborg University
Per Halfdan Nielsen
Per Halfdan Nielsen University of Copenhagen
Arne Schousboe
Arne Schousboe University of Copenhagen
Stephen F. Traynelis
Stephen F. Traynelis Emory University
Søren Buus
Søren Buus University of Copenhagen

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