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Biology and Biochemistry

D-Index
88
Citations
36087
World Ranking
2653
National Ranking
1379

Overview

Lloyd M. Smith is affiliated with the University of Wisconsin-Madison in the United States. The scientific work spans primarily the fields of biochemistry, genetics, and molecular biology, with additional specialization in chemistry.

Their main subfields of study include molecular biology, spectroscopy, surgery, biomedical engineering, and infectious diseases. Research topics cover a spectrum of advanced proteomics techniques and applications, mass spectrometry techniques, metabolomics, RNA and protein synthesis mechanisms, RNA research and splicing, genomics and phylogenetic studies, and RNA modifications in cancer.

Recent publications illustrate a focus on protein analysis and proteomics, including:

  • The Human Proteoform Project: Defining the human proteome (2021, Science Advances)
  • O-Pair Search with MetaMorpheus for O-glycopeptide characterization (2020, Nature Methods)
  • Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry (2020, Journal of the American Society for Mass Spectrometry)
  • Putting Humpty Dumpty Back Together Again: What Does Protein Quantification Mean in Bottom-Up Proteomics? (2022, Journal of Proteome Research)
  • An atlas of protein turnover rates in mouse tissues (2021, Nature Communications)

Lloyd M. Smith has frequent co-authors including Michael R. Shortreed, Robert J. Millikin, Mark Scalf, Erin D. Jeffery, and Simone Tiberi, reflecting collaborative research efforts.

Publications are frequently found in venues such as Zenodo (CERN European Organization for Nuclear Research), Journal of Proteome Research, bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, and Methods in Molecular Biology.

Best Publications

  • Fluorescence detection in automated DNA sequence analysis

    Lloyd M. Smith;Jane Z. Sanders;Robert J. Kaiser;Peter Hughes

  • Proteoform: a single term describing protein complexity

    Lloyd M Smith;Neil L Kelleher

  • How many human proteoforms are there

    Ruedi Aebersold;Jeffrey N. Agar;I. Jonathan Amster;Mark S. Baker

  • Early Warnings of Regime Shifts: A Whole-Ecosystem Experiment

    S. R. Carpenter;J. J. Cole;M. L. Pace;R. Batt

  • DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates.

    Wensha Yang;Orlando Auciello;James E. Butler;Wei Cai

  • Direct fluorescence analysis of genetic polymorphisms by hybridization with oligonucleotide arrays on glass supports

    Zhen Guo;Richard A. Guilfoyle;Andrew J. Thiel;Renfeng Wang

  • DNA computing on surfaces.

    Qinghua Liu;Liman Wang;Anthony G. Frutos;Anne E. Condon;Anne E. Condon

  • Synthesis and Characterization of DNA-Modified Silicon (111) Surfaces

    Todd Strother;Wei Cai;Xinsheng Zhao;Robert J. Hamers

  • Oligonucleotides possessing a primary amino group in the terminal nucleotide

    Lloyd M. Smith;Steven Fung;Robert J. Kaiser

  • The synthesis of oligonucleotides containing an aliphatic amino group at the 5′ terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis

    Lloyd M. Smith;Steven Fung;Michael W. Hunkapiller;Tim J. Hunkapiller

  • DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside

    Lloyd M. Smith;Steven Fung;Robert J. Kaiser

  • Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

    William C. Hallows;Wei Yu;Brian C. Smith;Mark K. Devries

  • Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes

    Elizabeth A. Hoffman;Brian L. Frey;Lloyd M. Smith;David T. Auble

  • Covalent attachment of oligodeoxyribonucleotides to amine-modified Si (001) surfaces

    Todd Strother;Robert J. Hamers;Lloyd M. Smith

  • Single-nucleotide Polymorphism Analysis by MALDI-TOF Mass Spectrometry

    Timothy J Griffin;Lloyd M Smith

  • In Situ Surface Plasmon Resonance Imaging Detection of DNA Hybridization to Oligonucleotide Arrays on Gold Surfaces

    Andrew J. Thiel;Anthony G. Frutos;Claire E. Jordan;and Robert M. Corn

  • Automated DNA sequencing technique

    Lloyd M. Smith;Leroy E. Hood;Michael W. Hunkapiller;Tim J. Hunkapiller

  • Demonstration of a word design strategy for DNA computing on surfaces.

    Anthony G. Frutos;Qinghua Liu;Andrew J. Thiel;Anne Marie W. Sanner

  • High-speed separations of DNA sequencing reactions by capillary electrophoresis

    Howard. Drossman;John A. Luckey;Anthony J. Kostichka;Jonathan. D'Cunha

  • High speed DNA sequencing by capillary electrophoresis

    John A. Luckey;Howard Drossman;Anthony J. Kostichka;David A. Mead

Frequent Co-Authors

Leroy Hood
Leroy Hood University of Washington
Robert J. Hamers
Robert J. Hamers University of Wisconsin–Madison
Richard D. Vierstra
Richard D. Vierstra Washington University in St. Louis
Michael W. Hunkapiller
Michael W. Hunkapiller Pacific Biosciences (United States)
Robert M. Corn
Robert M. Corn University of California, Irvine
Neil L. Kelleher
Neil L. Kelleher Northwestern University
Timothy J. Griffin
Timothy J. Griffin University of Minnesota
Ying Ge
Ying Ge University of Wisconsin–Madison
Anne Condon
Anne Condon University of British Columbia
Wei Cai
Wei Cai Stanford University

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