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D-Index
88
Citations
29981
World Ranking
13115
National Ranking
6692

Overview

Brian J. Bacskai is a researcher affiliated with Harvard University in the United States. Their work primarily focuses on medicine and neuroscience, with significant contributions in subfields such as cellular and molecular neuroscience, neurology, physiology, molecular biology, and cognitive neuroscience.

The main topics covered in their research include:

  • Alzheimer's disease research and treatments
  • Neuroscience and neuropharmacology research
  • Intracerebral and subarachnoid hemorrhage research
  • Photoreceptor and optogenetics research
  • Sleep and wakefulness research
  • Neuroinflammation and neurodegeneration mechanisms
  • Mitochondrial function and pathology

Brian J. Bacskai has authored and co-authored numerous scientific papers published in a variety of venues. Some recent papers include:

  • "Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease," 2020, Nature Communications
  • "Mitochondria and Calcium in Alzheimer's Disease: From Cell Signaling to Neuronal Cell Death," 2020, Trends in Neurosciences
  • "Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex," 2021, Acta Neuropathologica
  • "Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease," 2020, Frontiers in Neuroscience
  • "Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA)," 2020, Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring

Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Cerebral Blood Flow & Metabolism
  • Brain Communications
  • Scientific Reports
  • Alzheimer's & Dementia

Brian J. Bacskai collaborates frequently with a number of researchers, including:

  • Steven S. Hou
  • Steven M. Greenberg
  • María Calvo-Rodríguez
  • Susanne J. van Veluw
  • Ksenia V. Kastanenka

Best Publications

  • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

    Melanie Meyer-Luehmann;Tara L. Spires-Jones;Claudia Prada;Monica Garcia-Alloza

  • Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

    Steven M. Greenberg;Brian J. Bacskai;Mar Hernandez-Guillamon;Jeremy Pruzin

  • Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

    Monica Garcia-Alloza;Elissa M. Robbins;Sandy X. Zhang-Nunes;Susan M. Purcell

  • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.

    M. Garcia-Alloza;L. A. Borrelli;A. Rozkalne;B. T. Hyman

  • Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

    Kishore V. Kuchibhotla;Carli R. Lattarulo;Bradley T. Hyman;Brian J. Bacskai

  • Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

    Kishore V. Kuchibhotla;Samuel T. Goldman;Carli R. Lattarulo;Hai Yan Wu

  • Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons

    Brian J. Bacskai;Binyamin Hochner;Martyn Mahaut-Smith;Stephen R. Adams

  • Caspase activation precedes and leads to tangles

    Alix de Calignon;Leora M. Fox;Rose Pitstick;George A. Carlson

  • Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.

    Piera Pasinelli;Mary Elizabeth Belford;Niall Lennon;Brian J Bacskai

  • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

    Tara L. Spires;Melanie Meyer-Luehmann;Edward A. Stern;Pamela J. McLean

  • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.

    Brian J. Bacskai;Stephen T. Kajdasz;Richard H. Christie;Cordelia Carter

  • Reversible memory loss in a mouse transgenic model of Alzheimer's disease.

    Linda A. Kotilinek;Brian Bacskai;Marcus Westerman;Takeshi Kawarabayashi

  • Emerging concepts in sporadic cerebral amyloid angiopathy.

    Andreas Charidimou;Gregoire Boulouis;M. Edip Gurol;Cenk Ayata

  • A Lipophilic Thioflavin-T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain

    Chester A. Mathis;Brian J. Bacskai;Stephen T. Kajdasz;Megan E. McLellan

  • Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative

    William E. Klunk;Brian J. Bacskai;Chester A. Mathis;Stephen T. Kajdasz

  • Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.

    Niall J. Lennon;Alvin Kho;Brian J. Bacskai;Sarah L. Perlmutter

  • Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

    Hai Yan Wu;Eloise Hudry;Tadafumi Hashimoto;Kishore Kuchibhotla

  • Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β In Vivo by Immunotherapy

    Brian J. Bacskai;Stephen T. Kajdasz;Megan E. McLellan;Dora Games

  • In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

    Evgueni E. Nesterov;Jesse Skoch;Bradley T. Hyman;William E. Klunk

  • Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases.

    Erik N. T. P. Bakker;Brian J. Bacskai;Michal Arbel-Ornath;Roxana Aldea

Frequent Co-Authors

Bradley T. Hyman
Bradley T. Hyman Harvard University
Matthew P. Frosch
Matthew P. Frosch Harvard University
Steven M. Greenberg
Steven M. Greenberg Harvard University
Tara L. Spires-Jones
Tara L. Spires-Jones University of Edinburgh
Rebecca A. Betensky
Rebecca A. Betensky New York University
David A. Boas
David A. Boas Boston University
William E. Klunk
William E. Klunk University of Pittsburgh
Chester A. Mathis
Chester A. Mathis University of Pittsburgh
Roger Y. Tsien
Roger Y. Tsien University of California, San Diego
David M. Holtzman
David M. Holtzman Washington University in St. Louis

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