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Neuroscience

D-Index
74
Citations
22017
World Ranking
2093
National Ranking
218

Overview

Tara L. Spires-Jones is affiliated with the University of Edinburgh in the United Kingdom. Their research predominantly spans the fields of Medicine and Neuroscience, with considerable focus on Physiology, Neurology, Cellular and Molecular Neuroscience, Molecular Biology, and Pharmacology.

The scientist's work engages deeply with topics that include Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, neuroinflammation and neurodegeneration mechanisms, amyotrophic lateral sclerosis research, cholinesterase and neurodegenerative diseases, dementia and cognitive impairment research, and tryptophan and brain disorders.

Frequent coauthors collaborating with Spires-Jones include Jamie Rose, Jane Tulloch, Makis Tzioras, Colin Smith, and Declan King.

Their research has been published extensively in several venues, with notable contributions to bioRxiv (Cold Spring Harbor Laboratory), Brain Communications, Alzheimer's & Dementia, European Journal of Neuroscience, and Acta Neuropathologica.

Selected recent papers exemplifying the scope of their research include:

  • "The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics" (2020, Acta Neuropathologica)
  • "Microglia regulate central nervous system myelin growth and integrity" (2022, Nature)
  • "Synaptic degeneration in Alzheimer disease" (2022, Nature Reviews Neurology)
  • "The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease" (2020, Alzheimer's Research & Therapy)
  • "Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology" (2022, Nature Communications)

Best Publications

  • Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease

    Alix de Calignon;Manuela Polydoro;Marc Suárez-Calvet;Marc Suárez-Calvet;Christopher William

  • The intersection of amyloid beta and tau at synapses in Alzheimer’s disease

    Tara L. Spires-Jones;Bradley T. Hyman

  • Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.

    Melanie Meyer-Luehmann;Tara L. Spires-Jones;Claudia Prada;Monica Garcia-Alloza

  • Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

    Robert M. Koffie;Melanie Meyer-Luehmann;Tadafumi Hashimoto;Kenneth W. Adams

  • Caspase activation precedes and leads to tangles

    Alix de Calignon;Leora M. Fox;Rose Pitstick;George A. Carlson

  • Microglia regulate central nervous system myelin growth and integrity

    Unknown

  • The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.

    Hwan-Ching Tai;Alberto Serrano-Pozo;Tadafumi Hashimoto;Matthew P. Frosch

  • Synaptic degeneration in Alzheimer disease

    Unknown

  • Tau association with synaptic vesicles causes presynaptic dysfunction

    Lujia Zhou;Joseph McInnes;Keimpe Wierda;Matthew Holt

  • Interactions of pathological proteins in neurodegenerative diseases.

    Tara L. Spires-Jones;Johannes Attems;Dietmar Rudolf Thal

  • Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

    Hai Yan Wu;Eloise Hudry;Tadafumi Hashimoto;Kishore Kuchibhotla

  • The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics.

    Sarah A Kent;Tara L Spires-Jones;Claire S Durrant

  • Tau pathophysiology in neurodegeneration: a tangled issue.

    Tara L. Spires-Jones;William H. Stoothoff;Alix de Calignon;Phillip B. Jones

  • Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

    Tadafumi Hashimoto;Alberto Serrano-Pozo;Yukiko Hori;Kenneth W Adams

  • Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

    Robert M. Koffie;Tadafumi Hashimoto;Hwan-Ching Tai;Kevin R. Kay

  • Alzheimer's disease: synapses gone cold.

    Robert M Koffie;Bradley T Hyman;Tara L Spires-Jones

  • The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

    Martí Colom-Cadena;Tara Spires-Jones;Henrik Zetterberg;Kaj Blennow;Kaj Blennow

  • Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

    Christopher M. Henstridge;Bradley T. Hyman;Tara L. Spires-Jones

  • Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.

    Katherine J. Kopeikina;Katherine J. Kopeikina;George A. Carlson;Rose Pitstick;Adam E. Ludvigson

  • Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

    Nicholas J. Izzo;Jinbin Xu;Chenbo Zeng;Molly J. Kirk;Molly J. Kirk

  • Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

    Robert M. Koffie;Christian T. Farrar;Laiq-Jan Saidi;Christopher M. William

  • Soluble forms of tau are toxic in Alzheimer’s disease

    Katherine J Kopeikina;Bradley T Hyman;Tara L Spires-Jones

  • Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

    Amy M Pooler;Amy M Pooler;Manuela Polydoro;Eduardo A Maury;Samantha B Nicholls

  • Pathological Tau Disrupts Ongoing Network Activity

    Noa Menkes-Caspi;Hagar G. Yamin;Vered Kellner;Tara L. Spires-Jones

Frequent Co-Authors

Bradley T. Hyman
Bradley T. Hyman Harvard University
Ian J. Deary
Ian J. Deary University of Edinburgh
Allan F. McRae
Allan F. McRae University of Queensland
Joris de Wit
Joris de Wit KU Leuven
Mark E. Bastin
Mark E. Bastin University of Edinburgh
John M. Starr
John M. Starr University of Edinburgh
Joanna M. Wardlaw
Joanna M. Wardlaw University of Edinburgh
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Esther Berrocoso
Esther Berrocoso University of Cádiz

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