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H. Llewelyn Roderick

H. Llewelyn Roderick

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
20636
World Ranking
14156
National Ranking
254

Overview

H. Llewelyn Roderick is affiliated with KU Leuven in Belgium and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research primarily focuses on Molecular Biology and Cardiology and Cardiovascular Medicine, with significant intersections in Cellular and Molecular Neuroscience, Cancer Research, and Infectious Diseases.

The main topics of their work include:

  • Cardiac electrophysiology and arrhythmias
  • Ion channel regulation and function
  • Pluripotent Stem Cells Research
  • Neuroscience and Neural Engineering
  • Signaling Pathways in Disease
  • Receptor Mechanisms and Signaling
  • Cardiovascular Effects of Exercise

They have published extensively in several specialized venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory) with 8 publications
  • Journal of Molecular and Cellular Cardiology with 4 publications
  • Cells with 2 publications
  • Heart Rhythm with 2 publications
  • Journal of Cell Science with 2 publications

Among their recent notable papers are:

  • Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide, 2020, Science Translational Medicine
  • Ventricular Arrhythmias in Ischemic Cardiomyopathy-New Avenues for Mechanism-Guided Treatment, 2021, Cells
  • Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments, 2023, Journal of Clinical Investigation
  • Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation, 2021, Heart Rhythm
  • Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes, 2020, Journal of Molecular and Cellular Cardiology

Frequent co-authors that have collaborated with them include:

  • Karin R. Sipido
  • Matthew Amoni
  • Chandan K. Nagaraju
  • Piet Claus
  • Rosa Doñate Puertas

The publications reflect interdisciplinary work at the intersection of cardiac physiology, molecular mechanisms, and clinical implications, with various studies related to arrhythmias, myocardial remodeling, and molecular pathways involving ion channels and signaling processes relevant to cardiovascular health.

Best Publications

  • Calcium signalling: dynamics, homeostasis and remodelling

    Michael J. Berridge;Martin D. Bootman;H. Llewelyn Roderick

  • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

    Elizabeth L. Axe;Simon A. Walker;Maria Manifava;Priya Chandra

  • 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.

    Martin D. Bootman;Tony J. Collins;Lauren Mackenzie;H. Llewelyn Roderick

  • Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.

    H. Llewelyn Roderick;H. Llewelyn Roderick;Simon J. Cook

  • Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

    Rui-rui Chen;Ignacio Valencia;Fei Zhong;Karen S McColl

  • ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.

    Jason D. Oliver;H. Llewelyn Roderick;David H. Llewellyn;Stephen High

  • 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels

    Claire M. Peppiatt;Tony J. Collins;Lauren Mackenzie;Stuart J. Conway

  • Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells. A Potential Mechanism in Atherosclerotic Plaque Destabilization

    Alexandra E. Ewence;Martin D. Bootman;H. Llewelyn Roderick;Jeremy N. Skepper

  • Calcium signalling: more messengers, more channels, more complexity

    Martin D Bootman;Michael J Berridge;H.Llewelyn Roderick

  • The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

    Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong

  • Calcium Signaling in Cardiac Myocytes

    Claire J. Fearnley;H. Llewelyn Roderick;Martin D. Bootman

  • Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

    Tania Szado;Veerle Vanderheyden;Jan B. Parys;Humbert De Smedt

  • Cytosolic Phosphorylation of Calnexin Controls Intracellular Ca2+ Oscillations via an Interaction with Serca2b

    H. Llewelyn Roderick;James D. Lechleiter;Patricia Camacho

  • Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

    Yi Ping Rong;Ademuyiwa S. Aromolaran;Geert Bultynck;Fei Zhong

  • An update on nuclear calcium signalling.

    Martin D. Bootman;Claire Fearnley;Ioannis Smyrnias;Fraser MacDonald

  • Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes

    Jens Kockskämper;Aleksey V. Zima;H. Llewelyn Roderick;H. Llewelyn Roderick;Burkert Pieske

  • XTRPC1-dependent chemotropic guidance of neuronal growth cones

    Sangwoo Shim;Eyleen L. Goh;Shaoyu Ge;Kurt Sailor

  • Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

    Nael Nadif Kasri;Anthony M Holmes;Geert Bultynck;Jan B Parys

  • Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes

    Martin D. Bootman;Daniel R. Higazi;Stephen Coombes;H. Llewelyn Roderick;H. Llewelyn Roderick

  • The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

    Lauren Mackenzie;H. Llewelyn Roderick;Michael J. Berridge;Stuart J. Conway

Frequent Co-Authors

Martin D. Bootman
Martin D. Bootman The Open University
Michael J. Berridge
Michael J. Berridge Babraham Institute
Edmund J. Crampin
Edmund J. Crampin University of Melbourne
Jan B. Parys
Jan B. Parys KU Leuven
Andrew B. Holmes
Andrew B. Holmes University of Melbourne
Daniel M. Johnson
Daniel M. Johnson University of Georgia
Alexandra M. Z. Slawin
Alexandra M. Z. Slawin University of St Andrews

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