His main research concerns Cell biology, Endoplasmic reticulum, Calcium signaling, Receptor and Signalling. His Cell biology research is multidisciplinary, incorporating perspectives in Apoptosis, Programmed cell death and Calcium. In the subject of general Endoplasmic reticulum, his work in Golgi apparatus is often linked to Autophagy-Related Protein-1 Homolog, thereby combining diverse domains of study.
His studies in Calcium signaling integrate themes in fields like Neuroscience and Voltage-dependent calcium channel. His Signalling research incorporates elements of Cancer cell, Cancer, Cancer cell proliferation and Second messenger system. As part of the same scientific family, he usually focuses on Intracellular, concentrating on STIM2 and intersecting with Store-operated calcium entry and SOC channels.
H. Llewelyn Roderick mainly investigates Cell biology, Receptor, Calcium signaling, Internal medicine and Calcium. The Cell biology study combines topics in areas such as Apoptosis and Biochemistry. His Inositol study, which is part of a larger body of work in Receptor, is frequently linked to T-cell receptor, bridging the gap between disciplines.
His study focuses on the intersection of Calcium signaling and fields such as Depolarization with connections in the field of Cardiac function curve. His research integrates issues of Endocrinology and Cardiology in his study of Internal medicine. His Endoplasmic reticulum research incorporates themes from Programmed cell death and Transfection.
H. Llewelyn Roderick mainly focuses on Cell biology, Myocyte, Ryanodine receptor, Internal medicine and Epigenome. MAPK/ERK pathway and Calcium signaling are among the areas of Cell biology where H. Llewelyn Roderick concentrates his study. His research in Myocyte intersects with topics in Stimulation, Signal transduction, Endothelin 1 and Heart failure.
His studies deal with areas such as Biophysics and Live cell imaging as well as Ryanodine receptor. His Internal medicine research includes themes of Endocrinology, Ca2+/calmodulin-dependent protein kinase and Cardiology. His Calcium research focuses on NFAT and how it relates to Receptor and Inositol.
Myocyte, MAPK/ERK pathway, Endocrinology, Internal medicine and Lysyl oxidase are his primary areas of study. His study with Myocyte involves better knowledge in Cell biology. His Cell biology study combines topics in areas such as RNA, Membrane transport and Gene isoform.
The various areas that H. Llewelyn Roderick examines in his MAPK/ERK pathway study include Cancer cell, Growth factor receptor, Intracellular and Cell growth. As a part of the same scientific study, H. Llewelyn Roderick usually deals with the Endocrinology, concentrating on Ryanodine receptor and frequently concerns with Ventricular remodeling and Heart metabolism. His work in Heart failure tackles topics such as Sarcolemma which are related to areas like Calcium signaling.
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Calcium signalling: dynamics, homeostasis and remodelling.
Michael J. Berridge;Martin D. Bootman;H. Llewelyn Roderick.
Nature Reviews Molecular Cell Biology (2003)
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe;Simon A. Walker;Maria Manifava;Priya Chandra.
Journal of Cell Biology (2008)
2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.
Martin D. Bootman;Tony J. Collins;Lauren Mackenzie;H. Llewelyn Roderick.
The FASEB Journal (2002)
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.
H. Llewelyn Roderick;H. Llewelyn Roderick;Simon J. Cook.
Nature Reviews Cancer (2008)
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
Rui-rui Chen;Ignacio Valencia;Fei Zhong;Karen S McColl.
Journal of Cell Biology (2004)
ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.
Jason D. Oliver;H. Llewelyn Roderick;David H. Llewellyn;Stephen High.
Molecular Biology of the Cell (1999)
2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
Claire M. Peppiatt;Tony J. Collins;Lauren Mackenzie;Stuart J. Conway.
Cell Calcium (2003)
Calcium signalling: more messengers, more channels, more complexity
Martin D Bootman;Michael J Berridge;H.Llewelyn Roderick.
Current Biology (2002)
Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells. A Potential Mechanism in Atherosclerotic Plaque Destabilization
Alexandra E. Ewence;Martin D. Bootman;H. Llewelyn Roderick;Jeremy N. Skepper.
Circulation Research (2008)
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong.
Proceedings of the National Academy of Sciences of the United States of America (2009)
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