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Matthew P. Frosch

Matthew P. Frosch

D-Index & Metrics

Medicine

D-Index
127
Citations
77390
World Ranking
2786
National Ranking
1553

Overview

Matthew P. Frosch is affiliated with Harvard University in the United States. Their research spans multiple disciplines within medicine, biochemistry, genetics, molecular biology, and neuroscience, with a significant focus on neurological conditions.

The primary fields of study for Matthew P. Frosch include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, their work further specializes in several subfields such as:

  • Neurology
  • Physiology
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental Health

Their research topics focus mainly on neurodegenerative and neurovascular diseases, including:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Parkinson's Disease Mechanisms and Treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cerebrospinal fluid and hydrocephalus

Matthew P. Frosch has contributed to numerous publications. Selected recent papers include:

  • The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study (2022, The Lancet Neurology)
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020, Nature Communications)
  • Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease (2020, Nature Medicine)
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021, Cell)
  • Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma (2020, Nature Genetics)

The frequent co-authors associated with Matthew P. Frosch are:

  • Bradley T. Hyman
  • Derek H. Oakley
  • C. Dirk Keene
  • Dennis W. Dickson
  • Steven M. Greenberg

Their publications often appear in specific venues dedicated to neurological and biomedical sciences, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Acta Neuropathologica
  • Journal of Neuropathology & Experimental Neurology
  • Acta Neuropathologica Communications

Best Publications

  • Neuropathological Alterations in Alzheimer Disease

    Alberto Serrano-Pozo;Matthew P. Frosch;Eliezer Masliah;Bradley T. Hyman

  • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

    Bradley T. Hyman;Creighton H. Phelps;Thomas G. Beach;Eileen H. Bigio

  • National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

    Thomas J. Montine;Creighton H. Phelps;Thomas G. Beach;Eileen H. Bigio

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Cyril Neftel;Julie Laffy;Mariella G. Filbin;Toshiro Hara

  • Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

    Wesley Farris;Stefan Mansourian;Yang Chang;Loren Lindsley

  • Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

    Hideki Shimura;Michael G. Schlossmacher;Nobutaka Hattori;Matthew P. Frosch

  • A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

    Juan Eugenio Iglesias;Jean C. Augustinack;Khoa Nguyen;Christopher M. Player

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

    Itay Tirosh;Andrew S. Venteicher;Andrew S. Venteicher;Christine Hebert;Christine Hebert;Leah E. Escalante;Leah E. Escalante

  • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

    Andrew S. Venteicher;Andrew S. Venteicher;Itay Tirosh;Christine Hebert;Christine Hebert;Keren Yizhak;Keren Yizhak

  • Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

    Malcolm A Leissring;Wesley Farris;Alice Y Chang;Dominic M Walsh

  • Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

    Monica Garcia-Alloza;Elissa M. Robbins;Sandy X. Zhang-Nunes;Susan M. Purcell

  • Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

    Daryl A. Bosco;Gerardo A. Morfini;Gerardo A. Morfini;N. Murat Karabacak;Yuyu Song;Yuyu Song

  • Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

    M. Ingelsson;H. Fukumoto;K. L. Newell;J. H. Growdon

  • Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue

    Marta Marquié;Marta Marquié;Marc D. Normandin;Charles R. Vanderburg;Isabel M. Costantino

  • The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

    Ronit Sharon;Ifat Bar-Joseph;Matthew P Frosch;Dominic M Walsh

  • Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.

    Reisa A. Sperling;Reisa A. Sperling;Clifford R. Jack;Sandra E. Black;Matthew P. Frosch

  • Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup

    R.A. Sperling;C.R. Jack;S.E. Black;M.P. Frosch

Frequent Co-Authors

Bradley T. Hyman
Bradley T. Hyman Harvard University
Steven M. Greenberg
Steven M. Greenberg Harvard University
Brian J. Bacskai
Brian J. Bacskai Harvard University
John H. Growdon
John H. Growdon Harvard University
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Anand Viswanathan
Anand Viswanathan Harvard University
Rebecca A. Betensky
Rebecca A. Betensky New York University
Bruce Fischl
Bruce Fischl Harvard University
Thomas J. Montine
Thomas J. Montine Stanford University
Julie A. Schneider
Julie A. Schneider Rush University Medical Center

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