World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Best Female Scientists

D-Index
106
Citations
41408
World Ranking
1050
National Ranking
45

Biology and Biochemistry

D-Index
106
Citations
43142
World Ranking
1149
National Ranking
76

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Eva-Maria Mandelkow is affiliated with the German Center for Neurodegenerative Diseases in Germany. Their research primarily focuses on the pathophysiology and molecular mechanisms involved in neurodegenerative disorders, particularly Alzheimer's disease.

The scientist's work spans several main fields of study, including:

  • Medicine
  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology

Within these fields, the research touches on multiple subfields, such as:

  • Physiology
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Neurology
  • Biochemistry

Key topics in Eva-Maria Mandelkow's research include:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Prion Diseases and Protein Misfolding
  • Amino Acid Enzymes and Metabolism
  • Point processes and geometric inequalities
  • Advanced Proteomics Techniques and Applications

The scientist has been frequently published in a range of venues with several repeated contributions to notable journals:

  • Journal of Biological Chemistry (3 publications)
  • Alzheimer's & Dementia Translational Research & Clinical Interventions (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Research Square (Research Square) (2 publications)
  • Molecular Neurodegeneration (1 publication)

Recent papers authored or co-authored by Eva-Maria Mandelkow include:

  • FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, 2020, Molecular Neurodegeneration
  • A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications, 2020, Journal of Biological Chemistry
  • RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease, 2021, Cell Death and Disease
  • Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes, 2020, Alzheimer's & Dementia Translational Research & Clinical Interventions
  • Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study, 2022, Molecular Neurobiology

Frequent co-authors working alongside Eva-Maria Mandelkow include:

  • Eckhard Mandelkow (11 joint publications)
  • Senthilvelrajan Kaniyappan (8 joint publications)
  • Marta Anglada-Huguet (7 joint publications)
  • Jacek Biernat (6 joint publications)
  • Heike Endepols (5 joint publications)

Best Publications

  • Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

    Jean C. Augustinack;Anja Schneider;Eva-Maria Mandelkow;Bradley T. Hyman

  • Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?

    Sophie Leclerc;Matthieu Garnier;Ralph Hoessel;Doris Marko

  • MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

    Gerard Drewes;Andreas Ebneth;Ute Preuss;Eva-Maria Mandelkow

  • Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

    J Biernat;N Gustke;G Drewes;E M Mandelkow

  • A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.

    E. Braak;Heiko Braak;Eva-Maria Mandelkow

  • Tau in Alzheimer's disease

    Eva-Maria Mandelkow;Eckhard Mandelkow

  • Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

    Eva-Maria Mandelkow;Eckhard Mandelkow

  • Domains of tau protein and interactions with microtubules.

    N. Gustke;B. Trinczek;J. Biernat;E.-M. Mandelkow

  • Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

    G Drewes;B Lichtenberg-Kraag;F Döring;E M Mandelkow

  • Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

    Hans Zempel;Edda Thies;Eckhard Mandelkow;Eva-Maria Mandelkow

  • Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study

    E.M. Mandelkow;E. Mandelkow;R.A. Milligan

  • Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau

    E.-M. Mandelkow;G. Drewes;J. Biernat;N. Gustke

  • RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

    T. Kampers;P. Friedhoff;J. Biernat;E.-M. Mandelkow

  • Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

    Yipeng Wang;Marta Martinez-Vicente;Ulrike Krüger;Susmita Kaushik

  • Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

    K. Baumann;E. M. Mandelkow;J. Biernat;Helen Piwnica-Worms

  • Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure.

    Martin von Bergen;Stefan Barghorn;Li Li;Alexander Marx

  • Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.

    A Schneider;J Biernat;M von Bergen;E Mandelkow

  • Microtubules and microtubule-associated proteins

    Eckhard Mandelkow;Eva-Maria Mandelkow

  • The release and trans-synaptic transmission of Tau via exosomes

    Yipeng Wang;Varun Balaji;Senthilvelrajan Kaniyappan;Lars Krüger

  • Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution†

    Peter Friedhoff;Anja Schneider;Eva-Maria Mandelkow;Eckhard Mandelkow

Frequent Co-Authors

Eckhard Mandelkow
Eckhard Mandelkow German Center for Neurodegenerative Diseases
Jacek Biernat
Jacek Biernat German Center for Neurodegenerative Diseases
Gerard Drewes
Gerard Drewes GlaxoSmithKline (United Kingdom)
Martin von Bergen
Martin von Bergen Helmholtz Centre for Environmental Research
Gabriele M. Rune
Gabriele M. Rune Universität Hamburg
Sergio Lavandero
Sergio Lavandero University of Chile
Evelina Gatti
Evelina Gatti Aix-Marseille University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Susmita Kaushik
Susmita Kaushik Albert Einstein College of Medicine
Ana Maria Cuervo
Ana Maria Cuervo Albert Einstein College of Medicine

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