World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
67
Citations
16037
World Ranking
6895
National Ranking
156

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Catalysis
  • Biochemistry

Sijbren Otto mainly investigates Dynamic combinatorial chemistry, Nanotechnology, Combinatorial chemistry, Organic chemistry and Stereochemistry. His study connects Computational biology and Dynamic combinatorial chemistry. In his study, Molecular conformation is strongly linked to Replication, which falls under the umbrella field of Nanotechnology.

Sijbren Otto has researched Combinatorial chemistry in several fields, including Disulfide bond and Aqueous solution. His research investigates the connection with Organic chemistry and areas like Medicinal chemistry which intersect with concerns in Enantiomeric excess and Chiral Lewis acid. The concepts of his Stereochemistry study are interwoven with issues in Receptor and Stability constants of complexes.

His most cited work include:

  • Dynamic combinatorial chemistry. (1246 citations)
  • Supramolecular systems chemistry (421 citations)
  • Mechanosensitive self-replication driven by self-organization. (325 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Dynamic combinatorial chemistry, Combinatorial chemistry, Nanotechnology, Molecular recognition and Supramolecular chemistry. His Dynamic combinatorial chemistry research incorporates elements of Theoretical computer science, Receptor, Catalysis, Solid-phase synthesis and Computational biology. The Combinatorial chemistry study combines topics in areas such as Disulfide bond, Molecule, Synthetic Receptors and Aqueous solution.

His work in the fields of Nanotechnology, such as Self-replication, intersects with other areas such as Molecular network and Chemistry. His Molecular recognition research incorporates themes from Stereochemistry, Polymer and Combinatorial Chemistry Techniques. He interconnects Covalent bond, Polymer chemistry and Self-assembly in the investigation of issues within Supramolecular chemistry.

He most often published in these fields:

  • Dynamic combinatorial chemistry (35.06%)
  • Combinatorial chemistry (29.22%)
  • Nanotechnology (26.62%)

What were the highlights of his more recent work (between 2015-2021)?

  • Dynamic combinatorial chemistry (35.06%)
  • Self-replication (9.09%)
  • Nanotechnology (26.62%)

In recent papers he was focusing on the following fields of study:

Sijbren Otto mostly deals with Dynamic combinatorial chemistry, Self-replication, Nanotechnology, Molecule and Supramolecular chemistry. Dynamic combinatorial chemistry is a subfield of Combinatorial chemistry that he investigates. His Self-replication study combines topics in areas such as Evolutionary biology and Distributed computing.

His Nanotechnology research is multidisciplinary, incorporating elements of Amphiphile, Micelle, Data science and Molecular systems. His Molecule research is multidisciplinary, incorporating perspectives in Biophysics, Macromolecule and Molecular dynamics. His Supramolecular chemistry research integrates issues from Covalent bond, Non-covalent interactions and Self-assembly.

Between 2015 and 2021, his most popular works were:

  • Diversification of self-replicating molecules (116 citations)
  • Chemical systems out of equilibrium (56 citations)
  • Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry (34 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Catalysis
  • Biochemistry

His scientific interests lie mostly in Dynamic combinatorial chemistry, Nanotechnology, Self-replication, Covalent bond and Supramolecular chemistry. With his scientific publications, his incorporates both Dynamic combinatorial chemistry and Linear sequence. His studies deal with areas such as Biological system, Computational biology and Random hexamer as well as Nanotechnology.

His Self-replication research includes elements of Data science and Molecular systems. His research in Covalent bond intersects with topics in Antiparallel, Disulfide bond, Functional group and Supramolecular polymers. The various areas that Sijbren Otto examines in his Supramolecular chemistry study include Self-assembly, Stereochemistry, Chemical physics and Autocatalysis.

Best Publications

  • Dynamic combinatorial chemistry.

    Peter T Corbett;Julien Leclaire;Laurent Vial;Kevin R West

  • Supramolecular systems chemistry

    Elio Mattia;Sijbren Otto

  • Mechanosensitive self-replication driven by self-organization.

    Jacqui M. A. Carnall;Christopher A. Waudby;Christopher A. Waudby;Ana M. Belenguer;Marc C. A. Stuart

  • Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry

    Jianwei Li;Piotr Nowak;Sijbren Otto

  • Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides

    Sijbren Otto;Ricardo L. E. Furlan;Jeremy K. M. Sanders

  • Hydrophobic interactions and chemical reactivity

    Sijbren Otto;Jan B. F. N. Engberts

  • Amplification of Acetylcholine-Binding Catenanes from Dynamic Combinatorial Libraries

    Ruby T S Lam;Ana M Belenguer;Sarah L Roberts;Christoph A Naumann

  • Dynamic Combinatorial Libraries of Macrocyclic Disulfides in Water

    Sijbren Otto;Ricardo L.E. Furlan;Jeremy K.M. Sanders

  • Diels-Alder reactions in water

    Sijbren Otto;Jan B.F.N. Engberts

  • Lewis acid catalysis of a Diels-Alder reaction in water

    Sijbren Otto;Federica Bertoncin;Jan B. F. N. Engberts

  • Dynamic combinatorial libraries: new opportunities in systems chemistry.

    Rosemary A. R. Hunt;Sijbren Otto

  • Million-fold acceleration of a Diels-Alder reaction due to combined Lewis acid and micellar catalysis in water

    Sijbren Otto;Jan B. F. N. Engberts;Jan C. T. Kwak

  • Dynamic Combinatorial Optimization of a Neutral Receptor That Binds Inorganic Anions in Aqueous Solution

    Sijbren Otto;Stefan Kubik

  • Diversification of self-replicating molecules

    Jan W. Sadownik;Elio Mattia;Piotr Nowak;Sijbren Otto

  • Effects of the Hydrophobicity of the Reactants on Diels-Alder Reactions in Water

    Ale Meijer;Sijbren Otto;Jan B.F.N. Engberts

  • Systems chemistry.

    Unknown

  • Reversible Covalent Chemistry in Drug Delivery

    Kevin R. West;Sijbren Otto

  • Dynamic combinatorial chemistry.

    Sijbren Otto;Ricardo L.E Furlan;Jeremy K.M Sanders

  • Diels-Alder Reactions in Water. Effects of Hydrophobicity and Hydrogen Bonding

    Sijbren Otto;Wilfried Blokzijl;Jan B.F.N. Engberts

  • A systematic study of ligand effects on a Lewis-acid-catalyzed Diels-Alder reaction in water. Water-enhanced enantioselectivity

    Sijbren Otto;Jan B. F. N. Engberts

  • Dynamic Molecular Networks: From Synthetic Receptors to Self-Replicators

    Sijbren Otto

  • From self-replication to replicator systems en route to de novo life

    Paul Adamski;Marcel Eleveld;Ankush Sood;Ádám Kun;Ádám Kun

Frequent Co-Authors

Jeremy K. M. Sanders
Jeremy K. M. Sanders University of Cambridge
Jan B. F. N. Engberts
Jan B. F. N. Engberts University of Groningen
Marc C. A. Stuart
Marc C. A. Stuart University of Groningen
Jasper van der Gucht
Jasper van der Gucht Wageningen University & Research
Steven L. Regen
Steven L. Regen Lehigh University
David C. Sherrington
David C. Sherrington University of Strathclyde
Peter A. G. Cormack
Peter A. G. Cormack University of Strathclyde
Andrew D. Bond
Andrew D. Bond University of Cambridge
Eörs Szathmáry
Eörs Szathmáry Parmenides Foundation
Kevin Pagel
Kevin Pagel Freie Universität Berlin

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