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Chemistry

D-Index
53
Citations
9100
World Ranking
13174
National Ranking
246

Overview

Gerard Roelfes is affiliated with the University of Groningen in the Netherlands, focusing research primarily within biochemistry, genetics, molecular biology, and chemistry. Their work spans multiple subfields, including molecular biology, organic chemistry, oncology, renewable energy, sustainability, the environment, and inorganic chemistry.

The scientist's research topics cover various areas with significant publication records in chemical synthesis and analysis, enzyme catalysis and immobilization, cyclopropane reaction mechanisms, click chemistry and applications, peptidase inhibition and analysis, microbial metabolic engineering and bioproduction, and microbial natural products and biosynthesis.

Roelfes's recent published papers include: Expanding the enzyme universe with genetically encoded unnatural amino acids (2020, Nature Catalysis), Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites (2020, Nature Catalysis), In Vivo Assembly of Artificial Metalloenzymes and Application in Whole-Cell Biocatalysis (2021, Angewandte Chemie International Edition), Boron catalysis in a designer enzyme (2024, Nature), and Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel-Crafts Alkylase (2021, ACS Catalysis).

Frequent collaborators include: A.M.W.H. Thunnissen, Zhi Zhou, Shreyans Chordia, Reinder H. de Vries, and Ivana Drienovská.

The scientist publishes regularly in venues such as Angewandte Chemie International Edition, ACS Catalysis, Angewandte Chemie, ChemBioChem, and ChemCatChem.

Best Publications

  • DNA-based asymmetric catalysis.

    Gerard Roelfes;Ben L. Feringa

  • DNA-based asymmetric catalysis

    Arnold J. Boersma;Rik P. Megens;Ben L. Feringa;Gerard Roelfes

  • End-on and side-on peroxo derivatives of non-heme iron complexes with pentadentate ligands: models for putative intermediates in biological iron/dioxygen chemistry.

    Gerard Roelfes;Vladislav Vrajmasu;Kui Chen;Raymond Y.N. Ho

  • The importance of catalytic promiscuity for enzyme design and evolution

    Reuben B. Leveson-Gower;Clemens Mayer;Gerard Roelfes

  • Catalytic Oxidation with a Non-Heme Iron Complex That Generates a Low-Spin FeIIIOOH Intermediate

    Gerard Roelfes;Marcel Lubben;Ronald Hage;Lawrence Que

  • Enantioselective Friedel-Crafts Reactions in Water Using a DNA-Based Catalyst

    Arnold J. Boersma;Ben L. Feringa;Gerard Roelfes

  • Catalytic enantioselective syn hydration of enones in water using a DNA-based catalyst

    Arnold J. Boersma;David Coquière;Danny Geerdink;Fiora Rosati

  • Iron Chemistry of a Pentadentate Ligand That Generates a Metastable Fe(III)-OOH Intermediate.

    J.G. Roelfes;M Lubben;K. Chen;R.Y.N. Ho

  • Expanding the enzyme universe with genetically encoded unnatural amino acids

    Ivana Drienovska;Gerard Roelfes

  • DNA-based catalytic enantioselective Michael reactions in water

    David Coquiere;Ben L. Feringa;Gerard Roelfes

  • Asymmetric Catalysis with Helical Polymers

    Rik P. Megens;Gerard Roelfes

  • Enantioselective artificial metalloenzymes by creation of a novel active site at the protein dimer interface.

    Jeffrey Bos;Fabrizia Fusetti;Arnold J. M. Driessen;Gerard Roelfes

  • Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids

    Ivana Drienovská;Ana Rioz-Martínez;Apparao Draksharapu;Gerard Roelfes

  • LmrR: A Privileged Scaffold for Artificial Metalloenzymes

    Gerard Roelfes

  • Highly enantioselective DNA-based catalysis

    Gerard Roelfes;Arnold J. Boersma;Ben L. Feringa

  • Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites

    Zhi Zhou;Gerard Roelfes

  • A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue.

    Ivana Drienovská;Clemens Mayer;Christopher Dulson;Gerard Roelfes

  • DNA-based asymmetric catalysis: sequence-dependent rate acceleration and enantioselectivity.

    Arnold J. Boersma;Jaap E. Klijn;Ben L. Feringa;Gerard Roelfes

  • Alpha,beta-unsaturated 2-acyl imidazoles as a practical class of dienophiles for the DNA-based catalytic asymmetric Diels-Alder reaction in water.

    Arnold J. Boersma;Ben L. Feringa;Gerard Roelfes

  • Artificial metalloenzymes for enantioselective catalysis.

    Jeffrey Bos;Gerard Roelfes

  • Supramolecular Assembly of Artificial Metalloenzymes Based on the Dimeric Protein LmrR as Promiscuous Scaffold.

    Jeffrey Bos;Wesley R Browne;Arnold J M Driessen;Gerard Roelfes

  • Artificial Metalloenzymes

    Unknown

Frequent Co-Authors

Ben L. Feringa
Ben L. Feringa University of Groningen
Wesley R. Browne
Wesley R. Browne University of Groningen
Bert Poolman
Bert Poolman University of Groningen
Ronald Hage
Ronald Hage Leiden University
Agustí Lledós
Agustí Lledós Autonomous University of Barcelona
Oscar P. Kuipers
Oscar P. Kuipers University of Groningen
Marianne G. Rots
Marianne G. Rots University Medical Center Groningen
Anthony L. Spek
Anthony L. Spek Utrecht University
Auke Meetsma
Auke Meetsma University of Groningen
Lawrence Que
Lawrence Que University of Minnesota

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