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Chemistry

D-Index
51
Citations
8522
World Ranking
14049
National Ranking
3642

Overview

Rudi Fasan is a researcher affiliated with the University of Rochester in the United States. Their academic work primarily spans the fields of Chemistry and Biochemistry, Genetics, and Molecular Biology, with a notable focus on Organic Chemistry and Molecular Biology as key subfields. Research topics favored by Fasan include cyclopropane reaction mechanisms, synthesis and catalytic reactions, crystallization and solubility studies, and X-ray diffraction in crystallography.

Fasan's publications cover a range of specialized themes such as catalytic C-H functionalization methods, enzyme catalysis and immobilization, and synthetic organic chemistry methods.

Frequent collaborators with whom Fasan has published multiple papers include:

  • Xinkun Ren
  • Ajay L. Chandgude
  • Donggeon Nam
  • Daniela Maria Carminati
  • Viktoria Steck

Fasan's work has appeared in a variety of scientific journals, mostly repeatedly in some key venues with significant publication counts. These venues are:

  • The Cambridge Structural Database
  • Journal of the American Chemical Society
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Nature Catalysis

Some of Fasan's recent scientific papers include:

  • "MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles" (2020), published in ACS Central Science
  • "Engineered and artificial metalloenzymes for selective C-H functionalization" (2021), published in Current Opinion in Green and Sustainable Chemistry
  • "A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones" (2021), published in Journal of the American Chemical Society
  • "Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C-H Amination Biocatalysts" (2020), published in Journal of the American Chemical Society
  • "Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors" (2022), published in Journal of the American Chemical Society

Best Publications

  • Tuning P450 Enzymes as Oxidation Catalysts

    Rudi Fasan

  • Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions.

    Oliver F Brandenberg;Rudi Fasan;Frances H Arnold

  • Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts

    Melanie Bordeaux;Vikas Tyagi;Rudi Fasan

  • Molecular basis of RNA recognition by the human alternative splicing factor Fox-1

    Sigrid D. Auweter;Rudi Fasan;Luc Reymond;Jason G. Underwood

  • Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties.

    Rudi Fasan;Mike M Chen;Nathan C Crook;Frances H Arnold

  • Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties

    Rudi Fasan;Mike M. Chen;Nathan C. Crook;Frances H. Arnold

  • Evolutionary History of a Specialized P450 Propane Monooxygenase

    Rudi Fasan;Yergalem T. Meharenna;Christopher D. Snow;Thomas L. Poulos

  • Using a β‐Hairpin To Mimic an α‐Helix: Cyclic Peptidomimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction

    Rudi Fasan;Ricardo L. A. Dias;Kerstin Moehle;Oliver Zerbe

  • Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene.

    Antonio Tinoco;Viktoria Steck;Vikas Tyagi;Rudi Fasan

  • Controlled oxidation of remote sp3 C—H bonds in artemisinin via P450 catalysts with fine tuned regio and stereoselectivity

    Kaidong Zhang;Brian M. Shafer;Matthew D. Demars;Harry A. Stern

  • P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates

    Ritesh Singh;Melanie Bordeaux;Rudi Fasan

  • Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

    Vikas Tyagi;Rachel B. Bonn;Rudi Fasan

  • Gram‐Scale Synthesis of Chiral Cyclopropane‐Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity

    Priyanka Bajaj;Gopeekrishnan Sreenilayam;Vikas Tyagi;Rudi Fasan

  • Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.

    Gopeekrishnan Sreenilayam;Rudi Fasan

  • Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction.

    Rudi Fasan;Ricardo L. A. Dias;Kerstin Moehle;Oliver Zerbe

  • Enzymatic C(sp3)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

    Ritesh Singh;Joshua N. Kolev;Philip A. Sutera;Rudi Fasan

  • Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts

    Gopeekrishnan Sreenilayam;Eric J. Moore;Viktoria Steck;Rudi Fasan

  • Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution

    Yang Wei;Antonio Tinoco;Viktoria Steck;Rudi Fasan

  • Chemo-enzymatic fluorination of unactivated organic compounds.

    Andrea Rentmeister;Frances H Arnold;Rudi Fasan;Rudi Fasan

  • Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C—H Functionalization

    Joshua N. Kolev;Kristen M. O’Dwyer;Craig T. Jordan;Rudi Fasan

  • P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity.

    Kaidong Zhang;Shady El Damaty;Rudi Fasan

Frequent Co-Authors

Frances H. Arnold
Frances H. Arnold California Institute of Technology
Craig T. Jordan
Craig T. Jordan University of Colorado Anschutz Medical Campus
Ricardo Augusto Dias
Ricardo Augusto Dias Universidade de São Paulo
John A. Robinson
John A. Robinson University of Zurich
Harold C. Smith
Harold C. Smith University of Rochester
Huimin Zhao
Huimin Zhao University of Illinois at Urbana-Champaign
Markus G. Grütter
Markus G. Grütter University of Zurich
Patrick Mehlen
Patrick Mehlen UniCancer Group
Lynne E. Maquat
Lynne E. Maquat University of Rochester

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