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Biology and Biochemistry

D-Index
50
Citations
6826
World Ranking
17783
National Ranking
7276

Overview

Harold C. Smith is affiliated with the University of Rochester in the United States and focuses their research primarily in the field of Medicine. Their work spans several subfields including Infectious Diseases, Cardiology and Cardiovascular Medicine, Molecular Biology, Immunology, and Plant Science.

The main research topics covered by Harold C. Smith include:

  • Viral Infections and Immunology Research
  • Interferon and Immune Responses
  • SARS-CoV-2 and COVID-19 Research
  • Viral Infections and Outbreaks Research
  • Hepatitis B Virus Studies
  • Disaster Response and Management
  • RNA and Protein Synthesis Mechanisms

Smith has contributed to scientific literature through multiple recent publications, highlighting research on viral infections and molecular mechanisms. Selected recent papers include:

  • "A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures," 2020, published in Viruses
  • "Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties," 2021, published in JCI Insight
  • "Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells," 2021, published in Journal of Biological Chemistry
  • "Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase," 2023, published in Antiviral Research
  • "Corrigendum to "Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase"," 2023, published in Antiviral Research

The frequent co-authors collaborating with Smith include:

  • Ryan P. Bennett
  • Jason D. Salter
  • Elena Postnikova
  • Yíngyún Caì
  • Shuǐqìng Yú

Smith's work has been published in a variety of scientific venues, with multiple publications appearing in:

  • Antiviral Research
  • Viruses
  • Journal of Biological Chemistry
  • JCI Insight
  • International Journal of Radiation Oncology*Biology*Physics

Best Publications

  • The APOBEC Protein Family: United by Structure, Divergent in Function

    Jason D. Salter;Ryan P. Bennett;Harold C. Smith

  • MESSENGER RNA EDITING IN MAMMALS: NEW MEMBERS OF THE APOBEC FAMILY SEEKING ROLES IN THE FAMILY BUSINESS

    Joseph E. Wedekind;Geoffrey S.C. Dance;Mark.P. Sowden;Harold C. Smith

  • Functions and regulation of the APOBEC family of proteins.

    Harold C. Smith;Ryan P. Bennett;Ayse Kizilyer;William M. McDougall

  • A guide to RNA editing.

    Harold C. Smith;Jonatha M. Gott;Maureen R. Hanson

  • APOBEC3G/CEM15 (hA3G) mRNA Levels Associate Inversely with Human Immunodeficiency Virus Viremia

    Xia Jin;Andy Brooks;Huiyuan Chen;Ryan Bennett

  • The Neurofibromatosis Type I Messenger RNA Undergoes Base-Modification RNA Editing

    Gary R. Skuse;Amedeo J. Cappione;Mark Sowden;Linda J. Metheny

  • Nuclear matrix-bound DNA synthesis: an in vitro system

    Harold C. Smith;Ronald Berezney

  • Spatial distribution of DNA loop attachment and replicational sites in the nuclear matrix

    H.C. Smith;E. Puvion;L.A. Buchholtz;R. Berezney

  • In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.

    Harold C. Smith;Shu-Ru Kuo;John W. Backus;Stanley G. Harris

  • Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.

    S G Harris;I Sabio;E Mayer;M F Steinberg

  • Redistribution of U-snRNPs during mitosis

    David L. Spector;Harold C. Smith

  • Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro.

    John W. Backus;Harold C. Smith

  • The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1

    Kefang Xie;Mark P. Sowden;Geoffrey S. C. Dance;Andrew T. Torelli

  • Overexpression of APOBEC-1 Results in Mooring Sequence-dependent Promiscuous RNA Editing (∗)

    Mark Sowden;Jonathan K. Hamm;Harold C. Smith

  • Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits

    Joseph E. Wedekind;Richard Gillilan;Alena Janda;Jolanta Krucinska

  • DNA polymerase α is tightly bound to the nuclear matrix of actively replicating liver

    Harold C. Smith;Ronald Berezney

  • Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats.

    J D Sparks;R Zolfaghari;C E Sparks;H C Smith

  • Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase.

    Chad A Galloway;Mark P Sowden;Harold C Smith

  • Apolipoprotein B mRNA sequences 3′ of the editing site are necessary and sufficient for editing and editosome assembly

    John W. Backus;Harold C. Smith

  • Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

    Yang Y;Smith Hc

Frequent Co-Authors

Ronald Berezney
Ronald Berezney University at Buffalo, State University of New York
Xia Jin
Xia Jin Chinese Academy of Sciences
Stephen Dewhurst
Stephen Dewhurst University of Rochester
Baek Kim
Baek Kim Emory University
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Nazzareno Ballatori
Nazzareno Ballatori University of Rochester
A. Craig Chinault
A. Craig Chinault Baylor College of Medicine
Maureen R. Hanson
Maureen R. Hanson Cornell University
Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
James F. Scott
James F. Scott University of St Andrews

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