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Molecular Biology

D-Index
56
Citations
9531
World Ranking
2219
National Ranking
1100

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Xiaojiang S. Chen is affiliated with the University of Southern California in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, focusing extensively on molecular biology, infectious diseases, virology, immunology, and epidemiology.

The scientist has contributed to a range of topics including:

  • RNA regulation and disease
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing
  • HIV Research and Treatment
  • RNA and protein synthesis mechanisms
  • SARS-CoV-2 and COVID-19 Research
  • DNA Repair Mechanisms

Notable recent publications include:

  • "SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response," 2021, published in mBio
  • "Polθ reverse transcribes RNA and promotes RNA-templated DNA repair," 2021, published in Science Advances
  • "The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness," 2022, published in Scientific Reports
  • "Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G," 2020, published in Nature Communications
  • "Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase," 2023, published in Science Advances

Frequent collaborators include Kyumin Kim, Fumiaki Ito, Hanjing Yang, Richard T. Pomerantz, and Leonid Minakhin.

Xiaojiang S. Chen's work frequently appears in publication venues such as:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Science Advances
  • Journal of Medicinal Chemistry

The scientist has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2017.

Best Publications

  • Structure of Small Virus-Like Particles Assembled from the L1 Protein of Human Papillomavirus 16

    Xiaojiang S. Chen;Robert L. Garcea;Ilya Goldberg;Gregory Casini

  • Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen

    Dahai Gai;Rui Zhao;Dawei Li;Carla V. Finkielstein

  • The structure and function of MCM from archaeal M.Thermoautotrophicum

    Ryan J. Fletcher;Brooke E. Bishop;Ronald P. Leon;Robert A. Sclafani

  • Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

    Dawei Li;Rui Zhao;Wayne Lilyestrom;Dahai Gai

  • The APOBEC-2 crystal structure and functional implications for the deaminase AID

    Courtney Prochnow;Ronda Bransteitter;Michael G. Klein;Myron F. Goodman

  • Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

    Lauren G. Holden;Courtney Prochnow;Y. Paul Chang;Ronda Bransteitter

  • Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry

    Xiaojiang S. Chen;Thilo Stehle;Stephen C. Harrison

  • Papillomavirus capsid protein expression in Escherichia coli: purification and assembly of HPV11 and HPV16 L1.

    Xiaojiang S Chen;Gregory Casini;Stephen C Harrison;Robert L Garcea

  • Interactions between Papillomavirus L1 and L2 Capsid Proteins

    Renée L. Finnen;Kimberly D. Erickson;Xiaojiang S. Chen;Robert L. Garcea

  • Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.

    Brooke Bishop;Jhimli Dasgupta;Michael Klein;Robert L. Garcea

  • Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

    Susan A Boackle;V.Michael Holers;Xiaojiang Chen;Gerda Szakonyi

  • Structure of complement receptor 2 in complex with its C3d ligand.

    Gerda Szakonyi;Joel M. Guthridge;Dawei Li;Kendra Young

  • A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization

    Wenbo Wang;Jianhui Nie;Courtney Prochnow;Carolyn Truong

  • Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

    Wayne Lilyestrom;Michael G. Klein;Rongguang Zhang;Andrzej Joachimiak

  • Surface-exposed Amino Acid Residues of HPV16 L1 Protein Mediating Interaction with Cell Surface Heparan Sulfate

    Maren Knappe;Sabrina Bodevin;Hans-Christoph Selinka;Dorothe Spillmann

  • Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

    Aaron S. Brewster;Ganggang Wang;Xian Yu;William B. Greenleaf

  • Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

    Annette N. Chiang;Juan-Carlos Valderramos;Raghavan Balachandran;Raj J. Chovatiya

  • A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

    Valeria Orrú;Sophia J. Tsai;Blanca Rueda;Edoardo Fiorillo

  • Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein

    Yi Zhang;Jhimli Dasgupta;Runlin Z. Ma;Lawrence Banks

  • Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.

    Aaron N Patrick;Joshua H Cabrera;Anna L Smith;Xiaojiang S Chen

Frequent Co-Authors

V. Michael Holers
V. Michael Holers University of Colorado Denver
José María Carazo
José María Carazo Spanish National Research Council
Taekjip Ha
Taekjip Ha Johns Hopkins University
Ellen Fanning
Ellen Fanning Vanderbilt University
Rui Zhao
Rui Zhao University of Colorado Anschutz Medical Campus
Myron F. Goodman
Myron F. Goodman University of Southern California
Robert L. Garcea
Robert L. Garcea University of Colorado Boulder
Rongguang Zhang
Rongguang Zhang Chinese Academy of Sciences
Joel M. Guthridge
Joel M. Guthridge Oklahoma Medical Research Foundation
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory

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