John B. Harley spends much of his time researching Immunology, Lupus erythematosus, Genetics, Autoimmune disease and Systemic lupus erythematosus. His Immunology study which covers Allele that intersects with Locus. His studies deal with areas such as Twin study, Immune system, Internal medicine, Genetic association and Anti-SSA/Ro autoantibodies as well as Lupus erythematosus.
His work on Genetics deals in particular with Genetic linkage, Candidate gene, Human leukocyte antigen, Genome-wide association study and Genetic predisposition. The Autoimmune disease study combines topics in areas such as Epigenetics and X chromosome. John B. Harley has included themes like Virus and Epstein–Barr virus in his Systemic lupus erythematosus study.
His primary areas of study are Immunology, Genetics, Systemic lupus erythematosus, Lupus erythematosus and Autoantibody. His research on Immunology frequently connects to adjacent areas such as Single-nucleotide polymorphism. John B. Harley combines subjects such as Nephritis, Family aggregation, Gene and Rheumatology with his study of Systemic lupus erythematosus.
The study incorporates disciplines such as Internal medicine, Connective tissue disease and Genetic predisposition in addition to Lupus erythematosus. His Autoantibody research focuses on Molecular biology and how it connects with RNA and Ribonucleoprotein. His Allele research is multidisciplinary, incorporating elements of Human leukocyte antigen and Genotype.
John B. Harley focuses on Genetics, Genome-wide association study, Immunology, Disease and Internal medicine. His research integrates issues of Genotyping, Linkage disequilibrium, Genetic association and Genetic architecture in his study of Genome-wide association study. His study in Autoantibody, Autoimmunity, Autoimmune disease, Immune system and Human leukocyte antigen is carried out as part of his studies in Immunology.
The various areas that he examines in his Autoantibody study include Systemic lupus erythematosus, Immune dysregulation, B-cell activating factor and Rheumatology. His study in Internal medicine is interdisciplinary in nature, drawing from both Lupus erythematosus, Endocrinology and Oncology. His Lupus erythematosus study combines topics in areas such as Connective tissue disease and Polymorphism.
The scientist’s investigation covers issues in Immunology, Disease, Genome-wide association study, Lupus erythematosus and Genetics. His Immunology and Autoantibody, Autoimmune disease, Autoimmunity, Anti-SSA/Ro autoantibodies and Pathogenesis investigations all form part of his Immunology research activities. His research in Disease intersects with topics in Diagnosis code, Immune system and Cohort.
His Genome-wide association study study combines topics from a wide range of disciplines, such as Medical record, Genetic predisposition, Genetic association and Genetic architecture. His Lupus erythematosus research includes elements of Regulation of gene expression, Rheumatoid arthritis and Polymorphism. In his study, Serology is strongly linked to Single-nucleotide polymorphism, which falls under the umbrella field of Internal medicine.
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Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
Melissa R Arbuckle;Micah T McClain;Mark V Rubertone;R Hal Scofield.
The New England Journal of Medicine (2003)
Human polymorphism at microRNAs and microRNA target sites.
Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang.
Frontiers in Genetics (2013)
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
John B. Harley;John B. Harley;John B. Harley;Marta E. Alarcón-Riquelme;Lindsey A. Criswell;Chaim O. Jacob.
Nature Genetics (2008)
NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations.
Anthony S. Fauci;John B. Harley;William C. Roberts;Victor J. Ferrans.
Annals of Internal Medicine (1982)
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
Ludmila Prokunina;Casimiro Castillejo-López;Fredrik Öberg;Iva Gunnarsson.
Nature Genetics (2002)
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
Biola M. Javierre;Agustin F. Fernandez;Julia Richter;Fatima Al-Shahrour.
Genome Research (2010)
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
J. A. James;K. M. Kaufman;A. D. Farris;E. Taylor-Albert.
Journal of Clinical Investigation (1997)
Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
Kathy L. Moser;Barbara R. Neas;Barbara R. Neas;Jane E. Salmon;Hua Yu.
Proceedings of the National Academy of Sciences of the United States of America (1998)
High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus.
T B Niewold;J Hua;T J A Lehman;J B Harley.
Genes and Immunity (2007)
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.
Micah T McClain;Latisha D Heinlen;Latisha D Heinlen;Gregory J Dennis;Jon Roebuck.
Nature Medicine (2005)
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