World's Best Scientists 2026 revealed!

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Immunology

D-Index
96
Citations
33358
World Ranking
858
National Ranking
78

Genetics

D-Index
95
Citations
32730
World Ranking
901
National Ranking
127

Medicine

D-Index
96
Citations
33359
World Ranking
9677
National Ranking
943

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Timothy J. Vyse is affiliated with King's College London in the United Kingdom. Their research primarily focuses on immunology and microbiology, with significant contributions also made in the field of medicine. Within these areas, Vyse's work spans several specialized subfields including immunology, rheumatology, genetics, molecular biology, and radiology, nuclear medicine, and imaging.

The scientist's main research topics cover systemic lupus erythematosus, T-cell and B-cell immunology, immune cell function and interaction, atherosclerosis and cardiovascular diseases, monoclonal and polyclonal antibodies research, chronic lymphocytic leukemia research, and interferon and immune responses.

Vyse's recent publications reflect a sustained engagement with complex autoimmune disorders and genetic susceptibility studies. Notable papers include:

  • Complement genes contribute sex-biased vulnerability in diverse disorders, 2020, Nature
  • Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups, 2021, Nature Communications
  • Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity, 2020, Human Molecular Genetics
  • Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study, 2020, The American Journal of Human Genetics
  • Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues, 2020, Nature Communications

Frequent collaborators include David Morris, Edward M Vital, Ian N Bruce, Carl D. Langefeld, and Yongfei Wang, indicating a multidisciplinary network within immunological and genetic research.

Vyse's work is regularly published in venues such as Annals of the Rheumatic Diseases, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Science Immunology, and Lara D. Veeken. These journals reflect a strong emphasis on rheumatology and immunology research.

Recognition for Vyse's contributions includes election as a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Human polymorphism at microRNAs and microRNA target sites.

    Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang

  • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

    John B. Harley;John B. Harley;John B. Harley;Marta E. Alarcón-Riquelme;Lindsey A. Criswell;Chaim O. Jacob

  • Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

    James Bentham;David L. Morris;Deborah S. Cunninghame Graham;Christopher L. Pinder

  • Genetic Analysis of Autoimmune Disease

    Timothy J Vyse;John A Todd

  • A high resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

    Paul I W de Bakker;Gil McVean;Pardis C Sabeti;Marcos M Miretti

  • Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

    Timothy J. Aitman;Rong Dong;Timothy J. Vyse;Penny J. Norsworthy

  • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

    Nicholas Simpson;Paul A. Gatenby;Anastasia Wilson;Shreya Malik

  • Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

    Min Ae Lee-Kirsch;Maolian Gong;Dipanjan Chowdhury;Lydia Senenko

  • Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

    Michelle M. A. Fernando;Christine R. Stevens;Emily C. Walsh;Philip Lawrence De Jager;Philip Lawrence De Jager;Philip Lawrence De Jager

  • Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

    Robert R Graham;Chris Cotsapas;Chris Cotsapas;Leela Davies;Rachel Hackett

  • FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

    Manuela Fanciulli;Penny J Norsworthy;Enrico Petretto;Rong Dong

  • Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

    Robert R. Graham;Chieko Kyogoku;Snaevar Sigurdsson;Irina A. Vlasova

  • Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.

    Christopher J. Lessard;Christopher J. Lessard;He Li;He Li;Indra Adrianto;John A. Ice

  • GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

    T J Vyse;B L Kotzin

  • Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    Jenny C. Taylor;Jenny C. Taylor;Hilary C. Martin;Stefano Lise;John Broxholme

  • Evidence for an Interferon-Inducible Gene, Ifi202, in the Susceptibility to Systemic Lupus

    Stephen J Rozzo;John D Allard;Divaker Choubey;Timothy J Vyse

  • Transancestral mapping and genetic load in systemic lupus erythematosus

    Carl D. Langefeld;Hannah C. Ainsworth;Deborah S. Cunninghame Graham;Jennifer A. Kelly

  • Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

    Andrew I Russell;Deborah S Cunninghame Graham;Christopher Shepherd;Cheri A Roberton

  • A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

    Swapan K. Nath;Shizhong Han;Xana Kim-Howard;Jennifer A. Kelly

  • Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

    Deborah S. Cunninghame Graham;David L. Morris;Tushar R. Bhangale;Lindsey A. Criswell

Frequent Co-Authors

John B. Harley
John B. Harley United States Department of Veterans Affairs
Marta E. Alarcón-Riquelme
Marta E. Alarcón-Riquelme University of Granada
Kenneth M. Kaufman
Kenneth M. Kaufman Cincinnati Children's Hospital Medical Center
Judith A. James
Judith A. James Oklahoma Medical Research Foundation
Patrick M. Gaffney
Patrick M. Gaffney Oklahoma Medical Research Foundation
Robert P. Kimberly
Robert P. Kimberly University of Alabama at Birmingham
Jennifer A. Kelly
Jennifer A. Kelly Oklahoma Medical Research Foundation
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
R. Hal Scofield
R. Hal Scofield University of Oklahoma Health Sciences Center
Kathy L. Moser
Kathy L. Moser Oklahoma Medical Research Foundation

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