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Chemistry

D-Index
82
Citations
22791
World Ranking
3115
National Ranking
1033

Biology and Biochemistry

D-Index
82
Citations
23017
World Ranking
3717
National Ranking
1845

Overview

Jere P. Segrest is affiliated with Vanderbilt University in the United States and has contributed extensively to research in medicine, particularly focusing on biochemistry, genetics, and molecular biology. Their work spans multiple subfields including surgery, endocrinology, diabetes and metabolism, molecular biology, oncology, and cancer research.

Their research primarily addresses topics related to cholesterol and lipid metabolism, diabetes, cardiovascular risks, and lipoproteins. Additional areas of study include drug transport and resistance mechanisms, cancer, lipids, and metabolism, lipoproteins and cardiovascular health, lipid metabolism and biosynthesis, and lipid metabolism and disorders.

Frequent co-authors in their research include Jay W. Heinecke, W. Sean Davidson, Karin Bornfeldt, Hyun D. Song, and Chongren Tang.

Jere P. Segrest's publications appear regularly in several academic journals, with notable recurring venues being the Journal of Lipid Research, Circulation Research, Nature Communications, Circulation, and Current Opinion in Lipidology.

Recent significant papers authored or co-authored by Jere P. Segrest include:

  • ABCA1 is an extracellular phospholipid translocase (2022, Nature Communications)
  • Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles (2020, Circulation Research)
  • Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II (2021, Journal of Lipid Research)
  • Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs (2023, Circulation)
  • Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes (2022, Journal of Lipid Research)

The body of work by Segrest covers both fundamental studies-such as the discovery of ABCA1's role as a phospholipid translocase-and applied clinical insights linking HDL function and cardiovascular disease risks in diabetes. Their publications demonstrate a consistent investigation of molecular mechanisms involving cholesterol efflux and HDL particle dynamics.

Best Publications

  • The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

    J P Segrest;M K Jones;H De Loof;C G Brouillette

  • [5] Molecular weight determination of glycoproteins by polyacrylamide gel electrophoresis in sodium dodecyl sulfate

    Jere P. Segrest;Richard L. Jackson

  • A molecular theory of lipid—protein interactions in the plasma lipoproteins

    Jere P. Segrest;Richard L. Jackson;Joel D. Morrisett;Antonio M. Gotto

  • Amphipathic helix motif: Classes and properties

    J P Segrest;H De Loof;J G Dohlman;C G Brouillette

  • Structure of apolipoprotein B-100 in low density lipoproteins

    Jere P. Segrest;Martin K. Jones;Hans De Loof;Nassrin Dashti

  • Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor.

    Byung H. Chung;Thomas Wilkinson;Jack C. Geer;Jere P. Segrest

  • Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis.

    J.P. Segrest;R.L. Jackson;E.P. Andrews;V.T. Marchesi

  • Chemical Characterization and Surface Orientation of the Major Glycoprotein of the Human Erythrocyte Membrane

    V. T. Marchesi;T. W. Tillack;R. L. Jackson;J. P. Segrest

  • Single vertical spin density gradient ultracentrifugation.

    Byung H. Chung;Jere P. Segrest;Marjorie J. Ray;John D. Brunzell

  • Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.

    Constantine Londos;Dawn L. Brasaemle;Charles J. Schultz;Jere P. Segrest

  • A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein.

    Jere P. Segrest;Martin K. Jones;Anthony E. Klon;Christopher J. Sheldahl

  • The amphipathic alpha helix: a multifunctional structural motif in plasma apolipoproteins.

    Jere P. Segrest;David W. Garber;Christie G. Brouillette;Stephen C. Harvey

  • Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine.

    G M Anantharamaiah;J L Jones;C G Brouillette;C F Schmidt

  • Major glycoprotein of the human erythrocyte membrane: evidence for an amphipathic molecular structure.

    Jere P. Segrest;Itzhak Kahane;Richard L. Jackson;Vincent T. Marchesi

  • Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.

    Armando J. Mendez;G. M. Anantharamaiah;Jere P. Segrest;John F. Oram

  • Only the Two End Helixes of Eight Tandem Amphipathic Helical Domains of Human Apo A-I Have Significant Lipid Affinity Implications for HDL Assembly

    Mayakonda N. Palgunachari;Vinod K. Mishra;Sissel Lund-Katz;Michael C. Phillips

  • Apolipoprotein-mediated Plasma Membrane Microsolubilization: ROLE OF LIPID AFFINITY AND MEMBRANE PENETRATION IN THE EFFLUX OF CELLULAR CHOLESTEROL AND PHOSPHOLIPID

    Kristin L. Gillotte;Mohamed Zaiou;Sissel Lund-Katz;G.M. Anantharamaiah

  • Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides.

    Epand Rm;Shai Y;Segrest Jp;Anantharamaiah Gm

  • Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide.

    Geeta Datta;Manjula Chaddha;Susan Hama;Mohamad Navab

  • Membrane proteins: amino acid sequence and membrane penetration.

    Jere P. Segrest;Richard J. Feldmann

Frequent Co-Authors

G. M. Anantharamaiah
G. M. Anantharamaiah University of Alabama at Birmingham
Richard M. Epand
Richard M. Epand McMaster University
Michael C. Phillips
Michael C. Phillips University of Pennsylvania
Sissel Lund-Katz
Sissel Lund-Katz University of Pennsylvania
W. Sean Davidson
W. Sean Davidson University of Cincinnati
Stephen C. Harvey
Stephen C. Harvey University of Pennsylvania
Richard W. Compans
Richard W. Compans Emory University
Jay W. Heinecke
Jay W. Heinecke University of Washington
Alan M. Fogelman
Alan M. Fogelman University of California, Los Angeles
Mohamad Navab
Mohamad Navab University of California, Los Angeles

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