The scientist’s investigation covers issues in Schwann cell, Myelin, Cell biology, Neuroscience and Integrin. His study in the field of Schwann cell proliferation is also linked to topics like ADAM17 Protein. Lawrence Wrabetz interconnects Molecular biology, Signal transduction, Neuregulin 1 and Transgene in the investigation of issues within Myelin.
Lawrence Wrabetz studies Cell biology, namely Laminin. His Neuroscience research includes themes of Phenotype and Cellular differentiation. His Integrin research is multidisciplinary, relying on both Peripheral nervous system, Axon and Cell adhesion molecule.
His scientific interests lie mostly in Cell biology, Myelin, Schwann cell, Neuroscience and Molecular biology. Lawrence Wrabetz has researched Cell biology in several fields, including Peripheral nervous system and Immunology. He has included themes like Endoplasmic reticulum, Biochemistry and Neuregulin 1 in his Myelin study.
His biological study spans a wide range of topics, including Gene expression, Transcription factor, Downregulation and upregulation, Wallerian degeneration and Receptor. His Neuroscience study combines topics from a wide range of disciplines, such as Cellular differentiation, c-jun and Nociception. His Molecular biology research is multidisciplinary, incorporating perspectives in Cell culture, Neuroglia, Mutation, Myelin basic protein and Genetically modified mouse.
Lawrence Wrabetz focuses on Cell biology, Myelin, Schwann cell, Peripheral nervous system and Myelin protein zero. His studies link Phenotype with Cell biology. Lawrence Wrabetz combines subjects such as Downregulation and upregulation, Leukodystrophy and Calcineurin with his study of Myelin.
His research in Peripheral nervous system intersects with topics in Myelin maintenance and Integrin. In his study, Wild type and Axon is strongly linked to Gene silencing, which falls under the umbrella field of Myelin protein zero. His work in Unfolded protein response tackles topics such as Schwann cell differentiation which are related to areas like Transcription factor, SOX2 and Mutant protein.
Lawrence Wrabetz mainly focuses on Cell biology, Myelin, Peripheral nervous system, Downregulation and upregulation and Schwann cell. He is interested in Unfolded protein response, which is a branch of Cell biology. His studies in Unfolded protein response integrate themes in fields like Phenotype, Myelin maintenance and Schwann cell differentiation.
The various areas that Lawrence Wrabetz examines in his Peripheral nervous system study include Myelin protein zero, Neuregulin 1 and MAPK/ERK pathway. His MAPK/ERK pathway research is multidisciplinary, incorporating elements of Oligodendrocyte-Myelin Glycoprotein, Sciatic nerve, PI3K/AKT/mTOR pathway and Protein kinase B. The concepts of his Schwann cell study are interwoven with issues in Cell, Transcription factor, Neurodegeneration, Neuroinflammation and Macrophage.
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c-Jun is a negative regulator of myelination
DB Parkinson;A Bhaskaran;P Arthur-Farraj;LA Noon.
Journal of Cell Biology (2008)
Conditional disruption of β1 integrin in Schwann cells impedes interactions with axons
M. Laura Feltri;Diana Graus Porta;Stefano C. Previtali;Alessandro Nodari.
Journal of Cell Biology (2002)
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
Ashwin Woodhoo;Maria B Duran Alonso;Anna Droggiti;Mark Turmaine.
Nature Neuroscience (2009)
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Indrajit Das;Agnieszka Krzyzosiak;Kim Schneider;Lawrence Wrabetz.
Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization
Fumiaki Saito;Steven A Moore;Rita Barresi;Michael D Henry.
Signals to promote myelin formation and repair
Carla Taveggia;Maria Laura Feltri;Lawrence Wrabetz.
Nature Reviews Neurology (2010)
Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice
Maria Pennuto;Elisa Tinelli;MariaChiara Malaguti;Ubaldo Del Carro.
P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells.
Maria Laura Feltri;Maurizio D'antonio;Stefano Previtali;Marina Fasolini.
Annals of the New York Academy of Sciences (1999)
Molecular Mechanisms of Inherited Demyelinating Neuropathies
Steven S. Scherer;Lawrence Wrabetz.
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis
Alessandra Bolino;Annalisa Bolis;Stefano Carlo Previtali;Giorgia Dina.
Journal of Cell Biology (2004)
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