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Biology and Biochemistry

D-Index
63
Citations
11398
World Ranking
10427
National Ranking
4526

Overview

Lawrence Wrabetz is affiliated with the University at Buffalo, State University of New York in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology; Neuroscience; and Medicine. Specific subfields of interest include Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Neurology, and Physiology.

The scientist's work frequently addresses topics such as Hereditary Neurological Disorders, Endoplasmic Reticulum Stress and Disease, Signaling Pathways in Disease, Lysosomal Storage Disorders Research, Neurogenesis and neuroplasticity mechanisms, Cellular transport and secretion, and Nerve injury and regeneration.

Several journals and publication venues have featured their research, notably Glia, bioRxiv (Cold Spring Harbor Laboratory), Journal of Neuroscience, Nature Communications, and Brain. These venues have hosted multiple contributions by Wrabetz, indicating an ongoing engagement with topics relevant to neuroscience and cellular pathology.

Key recent publications by Lawrence Wrabetz include:

  • Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction, 2020, Neuron
  • Brainstem Development Requires Galactosylceramidase and Is Critical for Pathogenesis in a Model of Krabbe Disease, 2020, Nature Communications
  • Prohibitin 1 Is Essential to Preserve Mitochondria and Myelin Integrity in Schwann Cells, 2021, Nature Communications
  • Mechanisms of Demyelination and Neurodegeneration in Globoid Cell Leukodystrophy, 2021, Glia
  • Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury, 2020, Journal of Neuroscience

Lawrence Wrabetz has collaborated extensively with frequent co-authors including M. Laura Feltri, Edward Hurley, Emma R. Wilson, Yannick Poitelon, and Nadav I. Weinstock. These collaborations reflect a network of expertise relevant to neurobiology and molecular mechanisms of disease.

Best Publications

  • c-Jun is a negative regulator of myelination

    DB Parkinson;A Bhaskaran;P Arthur-Farraj;LA Noon

  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

    Indrajit Das;Agnieszka Krzyzosiak;Kim Schneider;Lawrence Wrabetz

  • Conditional disruption of β1 integrin in Schwann cells impedes interactions with axons

    M. Laura Feltri;Diana Graus Porta;Stefano C. Previtali;Alessandro Nodari

  • Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

    Ashwin Woodhoo;Maria B Duran Alonso;Anna Droggiti;Mark Turmaine

  • Signals to promote myelin formation and repair

    Carla Taveggia;Maria Laura Feltri;Lawrence Wrabetz

  • Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization

    Fumiaki Saito;Steven A Moore;Rita Barresi;Michael D Henry

  • Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice

    Maria Pennuto;Elisa Tinelli;MariaChiara Malaguti;Ubaldo Del Carro

  • P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells.

    Maria Laura Feltri;Maurizio D'antonio;Stefano Previtali;Marina Fasolini

  • β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination

    Alessandro Nodari;Desirée Zambroni;Angelo Quattrini;Felipe A. Court

  • Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis

    Alessandra Bolino;Annalisa Bolis;Stefano Carlo Previtali;Giorgia Dina

  • Molecular Mechanisms of Inherited Demyelinating Neuropathies

    Steven S. Scherer;Lawrence Wrabetz

  • YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

    Yannick Poitelon;Camila Lopez-Anido;Kathleen Catignas;Caterina Berti

  • Axons regulate Schwann cell expression of the POU transcription factor SCIP

    S. S. Scherer;Da-Yuan Wang;R. Kuhn;G. Lemke

  • Schwann Cell-Specific Ablation of Laminin γ1 Causes Apoptosis and Prevents Proliferation

    Wei-Ming Yu;M. Laura Feltri;Lawrence Wrabetz;Sidney Strickland

  • Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent

    M.L. Feltri;S.S. Scherer;R. Nemni;J. Kamholz

  • Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice.

    Maurizio D’Antonio;Nicolò Musner;Cristina Scapin;Daniela Ungaro

  • Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice.

    Lawrence Wrabetz;Maurizio D'Antonio;Maria Pennuto;Gabriele Dati

  • P0 glycoprotein overexpression causes congenital hypomyelination of peripheral nerves

    Lawrence Wrabetz;Maria Laura Feltri;Angelo Quattrini;Daniele Imperiale

  • Role of integrins in the peripheral nervous system.

    Stefano C. Previtali;M. Laura Feltri;Juan J. Archelos;Angelo Quattrini

  • TACE (ADAM17) inhibits Schwann cell myelination

    Rosa La Marca;Federica Cerri;Keisuke Horiuchi;Angela Bachi

Frequent Co-Authors

M. Laura Feltri
M. Laura Feltri University at Buffalo, State University of New York
Angelo Quattrini
Angelo Quattrini Vita-Salute San Raffaele University
Albee Messing
Albee Messing University of Wisconsin–Madison
John Kamholz
John Kamholz University of Iowa Hospitals and Clinics
Michael E. Shy
Michael E. Shy University of Iowa
Steven S. Scherer
Steven S. Scherer University of Pennsylvania
John Svaren
John Svaren University of Wisconsin–Madison
Felipe A. Court
Felipe A. Court Buck Institute for Research on Aging
Rhona Mirsky
Rhona Mirsky University College London
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society

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