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Neuroscience

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282

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Overview

Rudolf Martini is affiliated with the University of Würzburg in Germany and has contributed extensively to the fields of neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their research focuses primarily on neuroinflammation and neurodegeneration mechanisms, neurogenesis and neuroplasticity, hereditary neurological disorders, immune cells in cancer, peripheral neuropathies and disorders, nerve injury and regeneration, and pathways involving inflammation biomarkers.

Their work spans several main fields and subfields of study, including:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

  • Neurology
  • Cellular and Molecular Neuroscience
  • Immunology
  • Molecular Biology
  • Developmental Neuroscience

Martini has published research in notable venues such as:

  • Experimental Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience
  • The EMBO Journal
  • Journal of Neuroinflammation

Frequent collaborators include:

  • Janos Groh
  • Dennis Klein
  • Xidi Yuan
  • Antoine-Emmanuel Saliba
  • Mikael Simons

Recent significant publications by Rudolf Martini include:

  • "TREM2 protects from atherosclerosis by limiting necrotic core formation," 2024, Nature Cardiovascular Research
  • "Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects," 2023, Nature Communications
  • "CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging," 2022, Nature Neuroscience
  • "Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline," 2021, Nature Aging
  • "Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration," 2021, The EMBO Journal

The scientific topics central to Martini's research include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Hereditary Neurological Disorders
  • Immune cells in cancer
  • Peripheral Neuropathies and Disorders
  • Nerve injury and regeneration
  • Inflammation biomarkers and pathways

Best Publications

  • Disruption of the mouse L1 gene leads to malformations of the nervous system

    Miriam Dahme;Udo Bartsch;Rudolf Martini;Rudolf Martini;Brigitte Anliker

  • Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve.

    R Martini;M Schachner

  • Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves

    Rudolf Martini

  • Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

    Karl Peter Giese;Rudolf Martini;Greg Lemke;Philippe Soriano

  • Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.

    Dirk Montag;Karl Peter Giese;Udo Bartsch;Rudolf Martini

  • Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve.

    R Martini;M Schachner

  • CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation

    Ralf A. Linker;Mathias Mäurer;Stefanie Gaupp;Rudolf Martini

  • Hypermyelination and demyelinating peripheral neuropathy in Pmp22 -deficient mice

    Katrin Adlkofer;Rudolf Martini;Adriano Aguzzi;Jürgen Zielasek

  • Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies

    R Martini;J Zielasek;K V Toyka;K P Giese

  • Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease.

    Rudolf Martini;Stefan Fischer;Rubèn López-Vales;Samuel David

  • Structural Abnormalities and Deficient Maintenance of Peripheral Nerve Myelin in Mice Lacking the Gap Junction Protein Connexin 32

    Patrizia Anzini;Dirk H.-H. Neuberg;Melitta Schachner;Eric Nelles

  • Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity.

    M. Fruttiger;D. Montag;M. Schachner;R. Martini

  • Glycans and the modulation of neural-recognition molecule function

    Melitta Schachner;Rudolf Martini

  • Impaired Differentiation of Schwann Cells in Transgenic Mice with Increased PMP22 Gene Dosage

    Josef P. Magyar;Rudolf Martini;Thomas Ruelicke;Adriano Aguzzi

  • The L2/HNK‐1 Carbohydrate Epitope is Involved in the Preferential Outgrowth of Motor Neurons on Ventral Roots and Motor Nerves

    R. Martini;Y. Xin;B. Schmitz;M. Schachner

  • CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

    Unknown

  • Disruption of the Gene for the Myelin-Associated Glycoprotein Improves Axonal Regrowth along Myelin in C57BL/Wlds Mice

    Marcel Schäfer;Marcus Fruttiger;Dirk Montag;Melitta Schachner

  • The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.

    Mohtashem Samsam;Weiqian Mi;Carsten Wessig;Jürgen Zielasek

  • The L2/HNK-1 carbohydrate is preferentially expressed by previously motor axon-associated Schwann cells in reinnervated peripheral nerves

    R Martini;M Schachner;TM Brushart

  • Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve.

    R. Martini;M. Schachner;A. Faissner

  • Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin

    R Martini;MH Mohajeri;S Kasper;KP Giese

Frequent Co-Authors

Melitta Schachner
Melitta Schachner Rutgers, The State University of New Jersey
Klaus V. Toyka
Klaus V. Toyka University of Würzburg
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Ueli Suter
Ueli Suter École Polytechnique Fédérale de Lausanne
Heinz Wiendl
Heinz Wiendl University of Münster
Dirk Montag
Dirk Montag Leibniz Institute for Neurobiology
Hans Werner Müller
Hans Werner Müller Heinrich Heine University Düsseldorf
Michael Sendtner
Michael Sendtner University of Würzburg
Karl Peter Giese
Karl Peter Giese King's College London
Claudia Sommer
Claudia Sommer University of Würzburg

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