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Medicine

D-Index
113
Citations
53044
World Ranking
4903
National Ranking
2655

Overview

Bruce D. Trapp is affiliated with the Cleveland Clinic Lerner College of Medicine in the United States. Their primary research interests encompass multiple areas within medicine and neuroscience, with a focus on pathology, neurology, and molecular biology. Trapp's work covers multiple sclerosis research studies, neuroinflammation and neurodegeneration mechanisms, and neurogenesis and neuroplasticity mechanisms among other topics.

The recent publications by Bruce D. Trapp highlight a multidisciplinary approach combining clinical insights and molecular research. Notable papers include:

  • "Target identification among known drugs by deep learning from heterogeneous networks," 2020, Chemical Science
  • "Mechanisms underlying progression in multiple sclerosis," 2020, Current Opinion in Neurology
  • "Gut microbes impact stroke severity via the trimethylamine N-oxide pathway," 2021, Cell Host & Microbe
  • "Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis," 2020, Acta Neuropathologica
  • "Aggressive multiple sclerosis (1): Towards a definition of the phenotype," 2020, Multiple Sclerosis Journal

Frequent co-authors working with Trapp include Kunio Nakamura, Daniel Ontaneda, Kedar Mahajan, Anthony Chomyk, and Ranjan Dutta. Their collaborative efforts appear extensively in various publications, demonstrating a consistent research network primarily focused on nervous system disorders.

Bruce D. Trapp regularly publishes in several scientific journals and venues. Among the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Multiple Sclerosis Journal
  • Acta Neuropathologica
  • Neurology
  • Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

The fields of study related to Trapp's research include medicine and neuroscience. Subfields explored are pathology and forensic medicine, neurology, molecular biology, developmental neuroscience, and genetics. Their main research topics can be categorized as follows:

  • Multiple Sclerosis Research Studies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Peripheral Neuropathies and Disorders
  • RNA regulation and disease
  • Cytokine Signaling Pathways and Interactions
  • RNA Research and Splicing

Best Publications

  • Axonal transection in the lesions of multiple sclerosis.

    Bruce D. Trapp;John Peterson;Richard M. Ransohoff;Richard Rudick

  • Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

    Bruce D Trapp;Klaus Armin Nave

  • Pathological mechanisms in progressive multiple sclerosis

    Don H Mahad;Bruce D Trapp;Hans Lassmann

  • PREMYELINATING OLIGODENDROCYTES IN CHRONIC LESIONS OF MULTIPLE SCLEROSIS

    Ansi Chang;Wallace W. Tourtellotte;Richard Rudick;Bruce D. Trapp

  • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

    Ranjan Dutta;Jennifer McDonough;Xinghua Yin;John Peterson

  • Subpial demyelination in the cerebral cortex of multiple sclerosis patients.

    Lars Bø;Christian A. Vedeler;Harald I. Nyland;Bruce D. Trapp

  • Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

    C Bjartmar;J.R Wujek;B.D Trapp

  • Axon-Glial Signaling and the Glial Support of Axon Function

    Klaus Armin Nave;Bruce D. Trapp

  • LINGO-1 negatively regulates myelination by oligodendrocytes.

    Sha Mi;Robert H Miller;Xinhua Lee;Martin L Scott

  • Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation.

    G. Stoll;J. W. Griffin;C. Y. Li;B. D. Trapp

  • Bace1 modulates myelination in the central and peripheral nervous system

    Xiangyou Hu;Caitlin W Hicks;Wanxia He;Philip Wong

  • Neurological disability correlates with spinal cord axonal loss and reduced N‐acetyl aspartate in chronic multiple sclerosis patients

    Carl Bjartmar;Grahame Kidd;Sverre Mörk;Richard Rudick

  • Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.

    Lars Bö;Ted M. Dawson;Steven Wesselingh;Sverre Mörk

  • Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

    Bruce D Trapp;Peter K Stys

  • Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L

    Aimin Zhou;Aimin Zhou;Jayashree Paranjape;Thomas L. Brown;Huiqin Nie

  • Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

    Stephen A Back;Therese M F Tuohy;Hanqin Chen;Nicholas Wallingford

  • Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences.

    Carl Bjartmar;Bruce D. Trapp

  • Axonal pathology in multiple sclerosis: relationship to neurologic disability.

    Bruce D. Trapp;Richard Ransohoff;Richard Rudick

  • Myelin-Associated Glycoprotein Is a Myelin Signal that Modulates the Caliber of Myelinated Axons

    Xinghua Yin;Thomas O. Crawford;John W. Griffin;Pang Hsien Tu

  • Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration

    L Bø;C A Vedeler;H Nyland;B D Trapp

Frequent Co-Authors

Grahame J. Kidd
Grahame J. Kidd Cleveland Clinic
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Richard A. Rudick
Richard A. Rudick Biogen (United States)
Wendy B. Macklin
Wendy B. Macklin University of Colorado Anschutz Medical Campus
Hans Lassmann
Hans Lassmann Medical University of Vienna
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Lawrence Wrabetz
Lawrence Wrabetz University at Buffalo, State University of New York
Peter K. Stys
Peter K. Stys University of Calgary
Stephen M. Rao
Stephen M. Rao Cleveland Clinic

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