World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
113
Citations
49284
World Ranking
4934
National Ranking
486

Research.com Recognitions

  • 2021 - King Faisal Prize

Overview

Robin J.M. Franklin is affiliated with the University of Cambridge in the United Kingdom. Their work spans multiple intersecting fields, primarily focusing on biochemistry, genetics, molecular biology, neuroscience, and medicine. The scientist's research is strongly represented across several subfields, including molecular biology, developmental neuroscience, neurology, pathology and forensic medicine, and cancer research.

Their research topics cover a range of mechanisms related to the nervous system and disease, with a particular emphasis on neurogenesis and neuroplasticity mechanisms, neuroinflammation and neurodegeneration mechanisms, multiple sclerosis research studies, microRNA in disease regulation, immune cells in cancer, RNA research and splicing, as well as single-cell and spatial transcriptomics.

Recent significant papers include:

  • Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes (2021, Nature Genetics)
  • Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain (2022, Nature Neuroscience)
  • Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration (2020, Neuron)
  • A map of transcriptional heterogeneity and regulatory variation in human microglia (2021, Nature Genetics)
  • Ageing and multiple sclerosis (2022, The Lancet Neurology)

The scientist frequently collaborates with a core group of co-authors, including Chao Zhao, Adam M. H. Young, Khalil S. Rawji, Björn Neumann, and David H. Rowitch. Their publication record shows a consistent presence in leading journals and venues such as bioRxiv (Cold Spring Harbor Laboratory), Glia, Nature Genetics, Nature Neuroscience, and Acta Neuropathologica.

Robin J.M. Franklin received the King Faisal Prize in 2021.

Best Publications

  • Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

    Timothy R. Hammond;Timothy R. Hammond;Timothy R. Hammond;Connor Dufort;Lasse Dissing-Olesen;Lasse Dissing-Olesen;Lasse Dissing-Olesen;Stefanie Giera;Stefanie Giera

  • Remyelination in the CNS: from biology to therapy

    Robin J. M. Franklin;Charles ffrench-Constant

  • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

    Veronique E. Miron;Amanda Boyd;Jing Wei Zhao;Tracy J. Yuen;Tracy J. Yuen

  • Debris clearance by microglia: an essential link between degeneration and regeneration

    H P H Neumann;M. R. Kotter;R J M Franklin

  • Why does remyelination fail in multiple sclerosis

    Robin J. M. Franklin

  • Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.

    Mark R. Kotter;Wen-Wu Li;Chao Zhao;Robin J. M. Franklin

  • Rejuvenation of regeneration in the aging central nervous system

    Julia M. Ruckh;Jing-Wei Zhao;Jennifer L. Shadrach;Peter van Wijngaarden

  • CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

    Malgorzata Zawadzka;Malgorzata Zawadzka;Leanne E. Rivers;Stephen P.J. Fancy;Stephen P.J. Fancy;Chao Zhao

  • Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

    Stephen P.J. Fancy;Sergio E. Baranzini;Chao Zhao;Dong-In Yuk

  • The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

    Fraser J. Sim;Chao Zhao;Jacques Penderis;Jacques Penderis;Robin J. M. Franklin

  • Neuronal vulnerability and multilineage diversity in multiple sclerosis

    Lucas Schirmer;Dmitry Velmeshev;Staffan Holmqvist;Max Kaufmann

  • Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

    Feng Mei;Stephen P J Fancy;Yun-An A Shen;Jianqin Niu

  • Retinoid X receptor gamma signaling accelerates CNS remyelination

    Jeffrey K Huang;Andrew A Jarjour;Brahim Nait Oumesmar;Christophe Kerninon

  • Regenerating CNS myelin — from mechanisms to experimental medicines

    Robin J M Franklin;Charles Ffrench-Constant

  • Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

    Siming Shen;Juan Sandoval;Victoria A Swiss;Jiadong Li

  • bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

    Heather A. Arnett;Stephen P. J. Fancy;John A. Alberta;Chao Zhao

  • Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

    Bastian G. Brinkmann;Amit Agarwal;Michael W. Sereda;Michael W. Sereda;Alistair N. Garratt

  • Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells

    A. K. Groves;S. C. Barnett;R. J. M. Franklin;A. J. Crang

  • Multiple sclerosis genetics.

    Stephen Sawcer;Robin J M Franklin;Maria Ban

  • Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination

    Mark R. Kotter;Anna Setzu;Fraser J. Sim;Nico Van Rooijen

Frequent Co-Authors

Chao Zhao
Chao Zhao University of Cambridge
William F. Blakemore
William F. Blakemore University of Cambridge
Charles ffrench-Constant
Charles ffrench-Constant University of Edinburgh
David H. Rowitch
David H. Rowitch University of Cambridge
Stephen P.J. Fancy
Stephen P.J. Fancy University of California, San Francisco
Susan C. Barnett
Susan C. Barnett University of Glasgow
Klaus-Armin Nave
Klaus-Armin Nave Max Planck Society
Siddharthan Chandran
Siddharthan Chandran University of Edinburgh
Ragnhildur Thóra Káradóttir
Ragnhildur Thóra Káradóttir University of Cambridge
Ueli Suter
Ueli Suter École Polytechnique Fédérale de Lausanne

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