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Biology and Biochemistry
UK
2023

D-Index & Metrics

Medicine

D-Index
119
Citations
69754
World Ranking
3828
National Ranking
378

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

David H. Rowitch is affiliated with the University of Cambridge in the United Kingdom. Their research is primarily positioned at the interface of biochemistry, genetics, molecular biology, medicine, and neuroscience, with a particular emphasis on molecular biology, genetics, neurology, developmental neuroscience, and cancer research.

Their recent publications reflect a focus on astrocytes, neural circuits, and cellular responses in the brain. Notable papers include:

  • "Reactive astrocyte nomenclature, definitions, and future directions," 2021, published in Nature Neuroscience
  • "Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map," 2020, published in Nature Neuroscience
  • "Behaviorally consequential astrocytic regulation of neural circuits," 2020, published in Neuron
  • "Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration," 2020, published in Neuron
  • "Origins and Proliferative States of Human Oligodendrocyte Precursor Cells," 2020, published in Cell

Their frequent co-authors include Robin J.M. Franklin, Harry Bulstrode, Theresa Bartels, Manideep Chavali, and Katherine Ridley, each collaborating on multiple publications.

David H. Rowitch's research appears regularly in several key venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Neuron
  • Nature Neuroscience
  • Glia

The scholar's work addresses several main topics in neuroscience and molecular biology, covering:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Genomics and Rare Diseases
  • Genetics and Neurodevelopmental Disorders
  • Immune cells in cancer
  • Epigenetics and DNA Methylation
  • MicroRNA in disease regulation

Overall, their research portfolio spans core areas of biochemistry and genetics applied to neurological and neurodevelopmental processes, with a concentration on cellular mechanisms underlying neurodegeneration, neuroplasticity, and genetic disorders. Their contributions include high-impact studies in multiple leading journals and extensive collaborations with notable co-authors in the field.

Best Publications

  • Neurotoxic reactive astrocytes are induced by activated microglia

    Shane A. Liddelow;Kevin A. Guttenplan;Laura E. Clarke;Frederick C. Bennett

  • Single-cell reconstruction of the early maternal–fetal interface in humans

    Roser Vento-Tormo;Roser Vento-Tormo;Mirjana Efremova;Rachel A. Botting;Margherita Y. Turco

  • Reactive astrocyte nomenclature, definitions, and future directions

    Carole Escartin;Elena Galea;András Lakatos;James P. O’Callaghan

  • Conserved role of intragenic DNA methylation in regulating alternative promoters

    Alika K. Maunakea;Raman P. Nagarajan;Mikhail Bilenky;Tracy J. Ballinger

  • Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

    Y. Chai;X. Jiang;Y. Ito;P. Bringas

  • Malignant glioma: Genetics and biology of a grave matter

    Elizabeth A. Maher;Frank B. Furnari;Robert M. Bachoo;David H. Rowitch

  • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

    Paul S. Danielian;David Muccino;David H. Rowitch;Simon K. Michael

  • Fate of the mammalian cardiac neural crest.

    X. Jiang;D.H. Rowitch;P. Soriano;A.P. McMahon

  • Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

    Q.Richard Lu;Tao Sun;Zhimin Zhu;Nan Ma

  • Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.

    Véronique Brault;Robert Moore;Stefanie Kutsch;Makoto Ishibashi

  • Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain

    Bénédicte Menn;Jose Manuel Garcia-Verdugo;Cynthia Yaschine;Oscar Gonzalez-Perez

  • Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.

    Q. Richard Lu;Dong In Yuk;John A. Alberta;Zhimin Zhu

  • Corridors of migrating neurons in the human brain and their decline during infancy

    Nader Sanai;Thuhien Nguyen;Rebecca A. Ihrie;Zaman Mirzadeh;Zaman Mirzadeh

  • Single-cell genomics identifies cell type-specific molecular changes in autism.

    Dmitry Velmeshev;Lucas Schirmer;Lucas Schirmer;Diane Jung;Maximilian Haeussler

  • Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

    Robert M Bachoo;Elizabeth A Maher;Keith L Ligon;Norman E Sharpless

  • Astrocytes and disease: a neurodevelopmental perspective

    Anna V. Molofsky;Robert Krenick;Erik Ullian;Hui-hsin Tsai

  • Developmental genetics of vertebrate glial–cell specification

    David H. Rowitch;Arnold R. Kriegstein

  • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

    Zeng Jie Yang;Tammy Ellis;Shirley L. Markant;Tracy Ann Read;Tracy Ann Read

  • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

    Ulrich Schüller;Vivi M. Heine;Vivi M. Heine;Junhao Mao;Alvin T. Kho

  • Challenges to curing primary brain tumours

    Kenneth Aldape;Kevin M Brindle;Louis Chesler;Rajesh Chopra

Frequent Co-Authors

Andrew P. McMahon
Andrew P. McMahon University of Southern California
Charles D. Stiles
Charles D. Stiles Harvard University
Keith L. Ligon
Keith L. Ligon Harvard University
Robin J.M. Franklin
Robin J.M. Franklin University of Cambridge
Stephen P.J. Fancy
Stephen P.J. Fancy University of California, San Francisco
Eric J. Huang
Eric J. Huang University of California, San Francisco
Chao Zhao
Chao Zhao University of Cambridge
Ulrich Schüller
Ulrich Schüller Universität Hamburg
Arturo Alvarez-Buylla
Arturo Alvarez-Buylla University of California, San Francisco
William D. Richardson
William D. Richardson University College London

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