World's Best Scientists 2026 revealed!
Jack P. Antel

Jack P. Antel

Award Badge
Neuroscience
Canada
2026
Award Badge
Immunology
Canada
2023

D-Index & Metrics

Neuroscience

D-Index
133
Citations
68540
World Ranking
250
National Ranking
5

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Canada Leader Award
  • 2025 - Research.com Neuroscience in Canada Leader Award
  • 2023 - Research.com Immunology in Canada Leader Award
  • 2023 - Research.com Medicine in Canada Leader Award
  • 2022 - Research.com Immunology in Canada Leader Award

Overview

Jack P. Antel is affiliated with McGill University in Canada. Their research output spans multiple aspects of neuroscience, biochemistry, genetics, molecular biology, immunology, and microbiology, with a primary focus on neuroinflammation, neurodegeneration, and immune-related mechanisms.

The main fields of study covered by their work include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Key subfields within these areas of expertise are:

  • Neurology
  • Immunology
  • Molecular Biology
  • Developmental Neuroscience
  • Pathology and Forensic Medicine

Their research topics emphasize:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Immune cells in cancer
  • Multiple Sclerosis Research Studies
  • Single-cell and spatial transcriptomics
  • MicroRNA in disease regulation
  • Immune Response and Inflammation

Frequent coauthors who have collaborated with Jack P. Antel include:

  • Alexandre Prat
  • Moein Yaqubi
  • Luke M. Healy
  • Jo Anne Stratton
  • Timothy E. Kennedy

The scientist's work has been published regularly in several venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Glia
  • Nature
  • Nature Communications
  • Brain

Representative recent publications of Jack P. Antel include:

  • "Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy," 2020, Nature Communications
  • "MAFG-driven astrocytes promote CNS inflammation," 2020, Nature
  • "Barcoded viral tracing of single-cell interactions in central nervous system inflammation," 2021, Science
  • "Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic," 2020, Journal of the Neurological Sciences
  • "Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases," 2023, Nature Communications

Best Publications

  • Identification of a unique TGF-β–dependent molecular and functional signature in microglia

    Oleg Butovsky;Mark P Jedrychowski;Craig S Moore;Ron Cialic

  • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

    Veit Rothhammer;Ivan D Mascanfroni;Lukas Bunse;Maisa C Takenaka

  • Development of a multiple sclerosis functional composite as a clinical trial outcome measure

    Gary R. Cutter;Monika L. Baier;Richard A. Rudick;Diane L. Cookfair

  • iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

    Edsel M. Abud;Ricardo N. Ramirez;Eric S. Martinez;Luke M. Healy

  • Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial†

    Kathleen Hawker;Paul O'Connor;Mark S. Freedman;Peter A. Calabresi

  • Microglial control of astrocytes in response to microbial metabolites

    Veit Rothhammer;Davis M. Borucki;Emily C. Tjon;Maisa C. Takenaka

  • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand.

    Bibiana Bielekova;Bonnie Goodwin;Nancy Richert;Irene Cortese

  • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

    T. Kuhlmann;V. Miron;Q. Cuo;C. Wegner

  • Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons.

    Neil R. Cashman;Heather D. Durham;Jan Krzysztof Blusztajn;Kenichiro Oda

  • TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes

    Carolyn S. Jack;Nathalie Arbour;Joshua Manusow;Vivianne Montgrain

  • An updated histological classification system for multiple sclerosis lesions

    Tanja Kuhlmann;Samuel Ludwin;Alexandre Prat;Jack Antel

  • Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.

    Nicola De Stefano;Sridar Narayanan;Gordon S. Francis;Rozie Arnaoutelis

  • Intrathecal pathogenic anti–aquaporin‐4 antibodies in early neuromyelitis optica

    Jeffrey L. Bennett;Chiwah Lam;Sudhakar Reddy Kalluri;Philippe Saikali

  • A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

    W Haenseler;S N Sansom;J Buchrieser;S E Newey

  • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study.

    N De Stefano;P M Matthews;L Fu;S Narayanan

  • Imaging axonal damage of normal-appearing white matter in multiple sclerosis.

    L Fu;P M Matthews;N De Stefano;K J Worsley

  • Comparison of polarization properties of human adult microglia and blood-derived macrophages

    Bryce A. Durafourt;Craig S. Moore;Domenick A. Zammit;Trina A. Johnson

  • Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

    Charles P. Couturier;Shamini Ayyadhury;Phuong U. Le;Javad Nadaf;Javad Nadaf

  • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo- controlled, randomized phase II trial

    Ludwig Kappos;Giancarlo Comi;Hillel Panitch;Joel Oger

  • Remyelination capacity of the MS brain decreases with disease chronicity

    T. Goldschmidt;J. Antel;F. B. König;W. Brück

  • Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial

    Jerry S. Wolinsky;Ponnada A. Narayana;Paul O'Connor;Patricia K. Coyle

  • Brain-immune connection: immuno-regulatory properties of CNS-resident cells.

    Burkhard Becher;Alexandre Prat;Jack P. Antel

  • Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))

    Oleg Butovsky;Mark P. Jedrychowski;Craig S. Moore;Ron Cialic

Frequent Co-Authors

Timothy E. Kennedy
Timothy E. Kennedy Montreal Neurological Institute and Hospital
Douglas L. Arnold
Douglas L. Arnold Montreal Neurological Institute and Hospital
Voon Wee Yong
Voon Wee Yong University of Calgary
Nathalie Arbour
Nathalie Arbour University of Montreal
Paul M. Matthews
Paul M. Matthews Imperial College London
Raymond P. Roos
Raymond P. Roos University of Chicago
Sridar Narayanan
Sridar Narayanan Montreal Neurological Institute and Hospital
Guillermina Almazan
Guillermina Almazan McGill University
Oleg Butovsky
Oleg Butovsky Brigham and Women's Hospital
André Olivier
André Olivier McGill University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Neuroscience online opens up a range of flexible opportunities. Many students are now choosing accelerated online degrees to complete their studies faster and enter the workforce sooner. This is especially valuable for students eager to pursue research, clinical, or industry careers.

When considering your career options, keep in mind that neuroscience intersects with several top degrees in the world, from biomedical engineering to computer science and psychology. These fields are well known for their growth potential and high starting salaries.

In fact, many neuroscience-related majors are listed among the most lucrative degrees for college graduates. Pairing neuroscience with a data science or pre-med track can further boost your earning potential and expand your job prospects.

If cost is a concern, explore the fafsa approved online colleges that offer affordable tuition and financial aid options. These institutions help make a neuroscience education attainable for students from all backgrounds.

Best Scientists Citing Jack P. Antel

Trending Scientists