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D-Index & Metrics

Molecular Biology

D-Index
46
Citations
6558
World Ranking
2822
National Ranking
76

Overview

W. Kruijer is affiliated with the University of Twente in the Netherlands and works primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research encompasses several subfields, including Cancer Research, Immunology, and Pathology and Forensic Medicine.

The scientist's recent publications include work focused on genetic and molecular investigations relevant to disease mechanisms. Notable papers include:

  • Whole Exome Sequencing in Multi-Incident Families Identifies Novel Candidate Genes for Multiple Sclerosis, 2022, International Journal of Molecular Sciences
  • Whole exome sequencing in multi-incident families identifies novel candidate genes for multiple sclerosis, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Kruijer's research topics focus on molecular mechanisms associated with diseases, particularly involving microRNA in disease regulation and cancer-related molecular mechanisms research. Their studies also touch on immune system-related responses, such as interferon and immune responses, and specific disease areas like Multiple Sclerosis research studies.

Frequent coauthors collaborating with Kruijer include Julia Horjus, Marco Heerings, Ward De Witte, Dorothea Heersema, and Eva Strijbis. These collaborations have contributed to the body of work in their shared fields of study.

Kruijer's work has appeared in publication venues such as:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)

The scientist's consistent focus on cancer research and molecular biology is reflected in the concentration of their publications in related subfields and major topics. Their research blends genetic sequencing techniques and molecular biology approaches to investigate underlying disease pathways.

Best Publications

  • Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

    Wiebe Kruijer;Jonathan A. Cooper;Tony Hunter;Inder M. Verma

  • Growth factor-like action of phosphatidic acid

    W H Moolenaar;W Kruijer;B C Tilly;I Verlaan

  • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

    Diane Lejeune;Laure Dumoutier;Stefan Constantinescu;Wiebe Kruijer

  • Induction of the proto-oncogene fos by nerve growth factor

    Wiebe Kruijer;David Schubert;Inder M. Verma

  • Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

    J. Den Hertog;C. E. G. M. Pals;M. P. Peppelenbosch;L. G. J. Tertoolen

  • Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors.

    L H K Defize;J Boonstra;J Meisenhelder;W Kruijer

  • UV ACTIVATION OF RECEPTOR TYROSINE KINASE-ACTIVITY

    Coffer Pj;Burgering Bm;Peppelenbosch Mp;Bos Jl

  • Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes.

    W Kruijer;H Skelly;F Botteri;H van der Putten

  • Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5

    W. Kruijer;F.M.A. van Schaik;J.S. Sussenbach

  • Characterization of a negative retinoic acid response element in the murine Oct4 promoter.

    J Schoorlemmer;A van Puijenbroek;M van Den Eijnden;L Jonk

  • Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells.

    R. P. De Groot;F. A. E. Kruyt;P. T. Van Der Saag;W. Kruijer

  • Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element.

    E. Caldenhoven;P. Coffer;Juping Yuan;A. Van De Stolpe

  • Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.

    Jan-Jacob Schuringa;Luigi J. C. Jonk;Wim H. A. Dokter;Edo Vellenga

  • Activation of junB by PKC and PKA signal transduction through a novel cis-acting element

    R P de Groot;J Auwerx;M Karperien;B Staels

  • MEN2A-RET-induced cellular transformation by activation of STAT3

    Jan Jacob Schuringa;Katarzyna Wojtachnio;Werner Hagens;Edo Vellenga

  • Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation

    Jan-Jacob Schuringa;Lodewijk V. Dekker;Edo Vellenga;Wiebe Kruijer

  • INTERLEUKIN-6-INDUCED SERINE PHOSPHORYLATION OF TRANSCRIPTION FACTOR APRF : EVIDENCE FOR A ROLE IN INTERLEUKIN-6 TARGET GENE INDUCTION

    Claudia Lütticken;Paul Coffer;Juping Yuan;Claudia Schwartz

  • Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression

    M. C. Slootweg;R. P. de Groot;M. P. M. Herrmann-Erlee;I. Koornneef

  • Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.

    J. Den Hertog;J. Sap;C. E. G. M. Pals;J. Schlessinger

  • c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 response element (IRE)

    Jan-Jacob Schuringa;Hilko Timmer;Daniël Luttickhuizen;Edo Vellenga

Frequent Co-Authors

S. W. De Laat
S. W. De Laat Utrecht University
Christine L. Mummery
Christine L. Mummery Leiden University Medical Center
Johannes Boonstra
Johannes Boonstra Utrecht University
Arie J. Verkleij
Arie J. Verkleij Utrecht University
Frank A.E. Kruyt
Frank A.E. Kruyt University Medical Center Groningen
Wouter H. Moolenaar
Wouter H. Moolenaar Antoni van Leeuwenhoek Hospital
Jan Jacob Schuringa
Jan Jacob Schuringa University Medical Center Groningen
Leon G.J. Tertoolen
Leon G.J. Tertoolen Leiden University Medical Center
Maikel P. Peppelenbosch
Maikel P. Peppelenbosch Erasmus University Rotterdam
Edo Vellenga
Edo Vellenga University Medical Center Groningen

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