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Biology and Biochemistry

D-Index
40
Citations
6901
World Ranking
19584
National Ranking
682

Overview

Catherine J. Pallen is an academic researcher affiliated with the University of British Columbia in Canada. Their work spans several areas within biochemistry, genetics, molecular biology, and neuroscience. The research output includes investigations into cellular processes and cancer biology, with a focus on protein tyrosine phosphatases and mechanisms involving proteases and inhibitors.

The recent publications by the scientist include studies on cancer cell invasion and brain tumor modeling. One paper, published in 2021 in Molecular Biology of the Cell, is titled "Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion." Another article from 2023 published in Frontiers in Oncology is titled "Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment."

Catherine J. Pallen's collaborations often involve researchers such as Lisa R. Decotret, Kevin L. Bennewith, Brennan J. Wadsworth, Ling Li, and Chinten James Lim. These collaborations reflect a multidisciplinary approach crossing molecular biology, oncology, and neuroscience.

Frequent publication venues for Pallen's work include:

  • Molecular Biology of the Cell
  • Frontiers in Oncology

The main fields of study embraced by Pallen's research are:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, particular subfields covered include:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Immunology
  • Cancer Research
  • Biophysics

Key topics in Pallen's research portfolio are:

  • Protein Tyrosine Phosphatases
  • Galectins and Cancer Biology
  • Protease and Inhibitor Mechanisms
  • Neuroscience and Neural Engineering
  • Neuroscience and Neuropharmacology Research
  • Cell Image Analysis Techniques

Best Publications

  • Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase.

    Xin Min Zheng;Yue Wang;C. J. Pallen

  • F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.

    Qi Dong Hu;Qi Dong Hu;Beng Ti Ang;Beng Ti Ang;Meliha Karsak;Wei Ping Hu

  • PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

    Qi Zeng;Jing-Ming Dong;Ke Guo;Jie Li

  • Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells

    Brent W Sutherland;Jill Kucab;Joyce Wu;Cathy Lee

  • Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.

    Qi Zeng;Xiaoning Si;Heinrich Horstmann;Yue Xu

  • Calmodulin-stimulated dephosphorylation of p-nitrophenyl phosphate and free phosphotyrosine by calcineurin.

    C J Pallen;J H Wang

  • Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn

    Sathivel Ponniah;Dennis Z.M. Wang;Kah Leong Lim;Catherine J. Pallen

  • PRL PTPs: mediators and markers of cancer progression.

    Darrell C. Bessette;Dexin Qiu;Catherine J. Pallen

  • PTPα regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration

    Li Zeng;Xiaoning Si;Xiaoning Si;Wei-Ping Yu;Hoa Thi Le;Hoa Thi Le

  • Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.

    Tony L. Ng;Maureen J. O'Sullivan;Catherine J. Pallen;Malcolm Hayes

  • Regulation of calcineurin by metal ions. Mechanism of activation by Ni2+ and an enhanced response to Ca2+/calmodulin.

    C J Pallen;J H Wang

  • Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin.

    B Martin;C J Pallen;J H Wang;D J Graves

  • The receptor-like protein tyrosine phosphatase HPTP alpha has two active catalytic domains with distinct substrate specificities.

    Yue Wang;C. J. Pallen

  • Protein Tyrosine Phosphatase α (Ptpα) and Contactin Form a Novel Neuronal Receptor Complex Linked to the Intracellular Tyrosine Kinase Fyn

    Li Zeng;Luca D'Alessandri;Markus B. Kalousek;Lloyd Vaughan

  • Elevation of membrane tyrosine phosphatase activity in density-dependent growth-arrested fibroblasts.

    Catherine J. Pallen;Poay Hiang Tong

  • Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects.

    Catherine J Pallen

  • Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility

    Lihua Wu;Joie A. Bernard-Trifilo;Yangmi Lim;Ssang-Taek Lim;Ssang-Taek Lim

  • YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

    Abbas Fotovati;Samah Abu-Ali;Pei Shan Wang;Loic P. Deleyrolle

  • A multifunctional calmodulin-stimulated phosphatase.

    Catherine J. Pallen;Jerry H. Wang

  • Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.

    Vijay Bhandari;Kah Leong Lim;Catherine J. Pallen

Frequent Co-Authors

Zhi-Cheng Xiao
Zhi-Cheng Xiao Monash University
Melitta Schachner
Melitta Schachner Rutgers, The State University of New Jersey
Kah-Leong Lim
Kah-Leong Lim Nanyang Technological University
Wanjin Hong
Wanjin Hong Agency for Science, Technology and Research
David D. Schlaepfer
David D. Schlaepfer University of California, San Diego
Michihiko Kuwano
Michihiko Kuwano Kyushu University
Mike Waterfield
Mike Waterfield Ludwig Cancer Research
Eng-Ang Ling
Eng-Ang Ling National University of Singapore
Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Min Chen
Min Chen South China University of Technology

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