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Biology and Biochemistry

D-Index
84
Citations
35769
World Ranking
3249
National Ranking
1644

Overview

David D. Schlaepfer is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology. The scientist has contributed notably to the fields of molecular biology, cell biology, immunology and allergy, oncology, and immunology.

Their research topics encompass various aspects of cell adhesion molecules, cellular mechanics and interactions, Hippo pathway signaling and YAP/TAZ, ubiquitin and proteasome pathways, ovarian cancer diagnosis and treatment, immune cells in cancer, and pancreatic and hepatic oncology research.

Frequent publication venues for their work include:

  • Cancer Research
  • Gynecologic Oncology
  • Research Square (Research Square)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature reviews. Cancer

Among their recent papers are:

  • "Targeting FAK in anticancer combination therapies" (2021) published in Nature reviews. Cancer
  • "FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer" (2020) published in EMBO Molecular Medicine
  • "Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair" (2021) published in Nature Communications
  • "Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis" (2022) published in Proceedings of the National Academy of Sciences
  • "Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors" (2020) published in PLoS Genetics

Frequent collaborators include:

  • Dwayne G. Stupack, with 13 coauthored works
  • Marjaana Ojalill, with 10 coauthored works
  • Xiao Lei Chen, with 9 coauthored works
  • Duygu Ozmadenci, with 7 coauthored works
  • Antonia Boyer, with 6 coauthored works

Best Publications

  • Focal adhesion kinase: in command and control of cell motility

    Satyajit K. Mitra;Daniel A. Hanson;David D. Schlaepfer

  • Integrin-regulated FAK-Src signaling in normal and cancer cells.

    Satyajit K Mitra;David D Schlaepfer

  • FAK integrates growth-factor and integrin signals to promote cell migration

    David J. Sieg;Christof R. Hauck;Dusko Ilic;Candice K. Klingbeil

  • Signaling through focal adhesion kinase

    David D Schlaepfer;Christof R Hauck;David J Sieg

  • FAK in cancer: mechanistic findings and clinical applications

    Florian J. Sulzmaier;Christine Jean;David D. Schlaepfer

  • Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

    David J. Sieg;Christof R. Hauck;David D. Schlaepfer

  • Differential regulation of cell motility and invasion by FAK

    Datsun A. Hsia;Satyajit K. Mitra;Christof R. Hauck;Christof R. Hauck;Christof R. Hauck;Daniel N. Streblow

  • Integrin signalling and tyrosine phosphorylation: just the FAKs?

    David D Schlaepfer;Tony Hunter

  • Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

    Ana M. Pasapera;Ian C. Schneider;Ian C. Schneider;Erin Rericha;Erin Rericha;David D. Schlaepfer

  • Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.

    D D Schlaepfer;T Hunter

  • Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

    Duško Ilić;Eduardo A.C. Almeida;David D. Schlaepfer;Paul Dazin

  • Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

    Xiang-Dong Ren;William B. Kiosses;David J. Sieg;Carol A. Otey

  • Control of motile and invasive cell phenotypes by focal adhesion kinase.

    David D Schlaepfer;Satyajit K Mitra;Dusko Ilic

  • Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins.

    D D Schlaepfer;M A Broome;T Hunter

  • Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events

    David D. Schlaepfer;K. C. Jones;Tony Hunter

  • Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

    Ssang-Taek Lim;Xiao Lei Chen;Yangmi Lim;Dan A. Hanson

  • Multiple connections link FAK to cell motility and invasion.

    David D Schlaepfer;Satyajit K Mitra

  • Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

    Hanane Laklai;Yekaterina A Miroshnikova;Michael W Pickup;Eric A Collisson

  • Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling

    Alexander F. Palazzo;Christina H. Eng;David D. Schlaepfer;Eugene E. Marcantonio

  • Fluid Shear Stress Activation of Focal Adhesion Kinase LINKING TO MITOGEN-ACTIVATED PROTEIN KINASES

    Song Li;Michael Kim;Ying-Li Hu;Shila Jalali

Frequent Co-Authors

Dwayne G. Stupack
Dwayne G. Stupack University of California, San Diego
Dusko Ilic
Dusko Ilic King's College London
Christof R. Hauck
Christof R. Hauck University of Konstanz
David A. Cheresh
David A. Cheresh University of California, San Diego
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Jun-Lin Guan
Jun-Lin Guan University of Cincinnati Medical Center
Elisabetta Dejana
Elisabetta Dejana Uppsala University
Caroline H. Damsky
Caroline H. Damsky University of California, San Francisco
Daniel N. Streblow
Daniel N. Streblow Oregon Health & Science University
Alfredo A. Molinolo
Alfredo A. Molinolo University of California, San Diego

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