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Biology and Biochemistry

D-Index
107
Citations
74957
World Ranking
1071
National Ranking
644

Overview

Jun-Lin Guan is affiliated with the University of Cincinnati Medical Center in the United States. Their research spans several interconnected fields within biochemistry, genetics, molecular biology, and medicine, with a significant focus on the molecular mechanisms underlying disease processes.

Their primary fields of study include Biochemistry, Genetics and Molecular Biology, with 87 publications, and Medicine, with 64 publications. Within these main areas, they explore various subfields including Molecular Biology, Epidemiology, Cell Biology, Immunology, and Cancer Research.

Key research topics addressed by Jun-Lin Guan include:

  • Autophagy in Disease and Therapy
  • Extracellular vesicles in disease
  • Endoplasmic Reticulum Stress and Disease
  • Ubiquitin and proteasome pathways
  • Cancer Cells and Metastasis
  • Phagocytosis and Immune Regulation
  • Epigenetics and DNA Methylation

The scientist has contributed to multiple studies published in high-profile venues. Frequent publication venues include:

  • Autophagy
  • Cell Reports
  • Nature Communications
  • Cancer Research
  • Developmental Cell

Recent papers reflect a focus on cancer biology, cellular communication, and immune regulation. Notable publications include:

  • FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication, 2020, Oncogene
  • Heterogeneity within molecular subtypes of breast cancer, 2021, American Journal of Physiology-Cell Physiology
  • Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis, 2020, JCI Insight
  • Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells, 2021, Nature Communications
  • Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response, 2020, Nature Cancer

The collaborative nature of their work is highlighted by frequent co-authorship with several researchers, including:

  • Syn Kok Yeo
  • Mingang Hao
  • Michael Haas
  • Jiajie Diao
  • Zhiqi Tian

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

    Chun Chi Liang;Ann Y. Park;Jun Lin Guan

  • Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

    Nao Hosokawa;Taichi Hara;Takeshi Kaizuka;Chieko Kishi

  • Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation

    Huilin Huang;Huilin Huang;Hengyou Weng;Hengyou Weng;Wenju Sun;Xi Qin;Xi Qin

  • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

    Taichi Hara;Akito Takamura;Chieko Kishi;Shun Ichiro Iemura

  • Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

    Jun-Lin Guan;David Shalloway

  • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

    Christophe Ginestier;Suling Liu;Mark E. Diebel;Hasan Korkaya

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

    Xiaofeng Zhao;Jun Lin Guan

  • Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

    L.A. Cary;J.F. Chang;J.L. Guan

  • Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

    Jun-Lin Guan;Richard O. Hynes

  • Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

    Jennifer Martinez;R. K.Subbarao Malireddi;Qun Lu;Larissa Dias Cunha

  • Signal transduction by focal adhesion kinase in cancer

    Jihe Zhao;Jun-Lin Guan

  • Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

    Hong Chen Chen;Jun Lin Guan

  • Wound-healing assay.

    Luis G. Rodriguez;Xiaoyang Wu;Jun-Lin Guan

  • Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase

    Hong Chen Chen;Paul A. Appeddu;Hiroko Isoda;Jun Lin Guan

  • Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

    Leslie A. Cary;Dong Cho Han;Thomas R. Polte;Steven K. Hanks

  • Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally

    Huilin Huang;Huilin Huang;Hengyou Weng;Hengyou Weng;Keren Zhou;Tong Wu

Frequent Co-Authors

Boyi Gan
Boyi Gan The University of Texas MD Anderson Cancer Center
Tatsuya Saitoh
Tatsuya Saitoh Osaka University
Noboru Mizushima
Noboru Mizushima University of Tokyo
Sergio Lavandero
Sergio Lavandero University of Chile
Richard A. Cerione
Richard A. Cerione Cornell University
Isei Tanida
Isei Tanida Juntendo University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Mitsunori Fukuda
Mitsunori Fukuda Tohoku University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Takeshi Noda
Takeshi Noda Osaka University

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