His primary areas of investigation include Cell biology, Extracellular matrix, Nanotechnology, Biophysics and Mechanotransduction. His Cell biology study incorporates themes from Cell growth, Cell adhesion, Cellular differentiation and Cytoskeleton. His Extracellular matrix research includes elements of Cell, Cell culture, Angiogenesis and Signal transduction.
His Nanotechnology research is multidisciplinary, relying on both Petri dish, Membrane, Cell shape and Polymer. His studies in Biophysics integrate themes in fields like Tissue engineering, Cell morphology, Durotaxis and Mechanotaxis. His research investigates the connection with Mechanotransduction and areas like Cell signaling which intersect with concerns in 3D cell culture.
His primary areas of study are Cell biology, Nanotechnology, Biophysics, Extracellular matrix and Tissue engineering. His work carried out in the field of Cell biology brings together such families of science as Cell adhesion, Cellular differentiation and Cytoskeleton. His research investigates the connection between Cellular differentiation and topics such as Stem cell that intersect with problems in Mesenchymal stem cell.
His work on Nanowire and Microcontact printing as part of general Nanotechnology study is frequently connected to Magnetic nanowires and Microfabrication, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. In Biophysics, Christopher S. Chen works on issues like Focal adhesion, which are connected to Cadherin. The various areas that Christopher S. Chen examines in his Extracellular matrix study include Cell culture, Morphogenesis and Matrix.
His primary scientific interests are in Cell biology, Tissue engineering, Extracellular matrix, Stromal cell and Biophysics. His study on Barrier function is often connected to Glycochenodeoxycholic acid as part of broader study in Cell biology. His Tissue engineering research integrates issues from Microfluidics, Self-healing hydrogels and Induced pluripotent stem cell.
In his research, Process is intimately related to Matrix, which falls under the overarching field of Extracellular matrix. While the research belongs to areas of Stromal cell, Christopher S. Chen spends his time largely on the problem of Apoptosis, intersecting his research to questions surrounding Liver function, Organoid and Function. His work deals with themes such as Myofibroblast, Electrophysiology, Nerve conduction velocity, Myocyte and Optical mapping, which intersect with Biophysics.
Christopher S. Chen spends much of his time researching Cell biology, Extracellular matrix, Morphogenesis, Cancer research and Contractility. In general Cell biology study, his work on Glycocalyx often relates to the realm of Biliatresone, thereby connecting several areas of interest. His Extracellular matrix research includes themes of Blood flow, Microvessel, Vascular permeability, Barrier function and Vascular endothelium.
His Morphogenesis research incorporates themes from Cell, Cytoskeleton, Downregulation and upregulation and Actin. Christopher S. Chen has included themes like Pancreatic ductal adenocarcinoma, Carcinoma, Ablation, Lumen and In vivo in his Cancer research study. His Contractility study integrates concerns from other disciplines, such as Sprouting, Angiogenesis, HEK 293 cells, Cell adhesion and Motility.
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Geometric control of cell life and death.
Christopher S. Chen;Milan Mrksich;Sui Huang;George M. Whitesides.
Science (1997)
CELL SHAPE, CYTOSKELETAL TENSION, AND RHOA REGULATE STEM CELL LINEAGE COMMITMENT
Rowena McBeath;Dana M Pirone;Celeste M Nelson;Kiran Bhadriraju.
Developmental Cell (2004)
Cells lying on a bed of microneedles: An approach to isolate mechanical force
John L. Tan;Joe Tien;Dana M. Pirone;Darren S. Gray.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
Andrew J. Maniotis;Christopher S. Chen;Donald E. Ingber.
Proceedings of the National Academy of Sciences of the United States of America (1997)
Control of stem cell fate by physical interactions with the extracellular matrix.
Farshid Guilak;Daniel M. Cohen;Bradley T. Estes;Jeffrey M. Gimble.
Cell Stem Cell (2009)
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Jordan S. Miller;Kelly R. Stevens;Michael T. Yang;Brendon M. Baker.
Nature Materials (2012)
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Brendon M. Baker;Christopher S. Chen.
Journal of Cell Science (2012)
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Carsten Grashoff;Brenton D. Hoffman;Michael D. Brenner;Ruobo Zhou.
Nature (2010)
Mechanical regulation of cell function with geometrically modulated elastomeric substrates
Jianping Fu;Jianping Fu;Yang Kao Wang;Yang Kao Wang;Michael T. Yang;Ravi A. Desai.
Nature Methods (2010)
Micropatterned Surfaces for Control of Cell Shape, Position, and Function
Christopher S. Chen;Milan Mrksich;Sui Huang;George M. Whitesides.
Biotechnology Progress (1998)
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