World's Best Scientists 2026 revealed!
Christopher S. Chen

Christopher S. Chen

Award Badge
Engineering and Technology
USA
2026

D-Index & Metrics

Engineering and Technology

D-Index
108
Citations
59132
World Ranking
89
National Ranking
33

Biology and Biochemistry

D-Index
125
Citations
74578
World Ranking
500
National Ranking
317

Research.com Recognitions

  • 2026 - Research.com Engineering and Technology in United States Leader Award
  • 2025 - Research.com Engineering and Technology in United States Leader Award

Overview

Christopher S. Chen is affiliated with Boston University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Molecular Biology, Biomedical Engineering, Oncology, Surgery, and Cardiology and Cardiovascular Medicine.

The scientist's work covers a range of topics with a focus on biomedical and cellular mechanics. Key areas of study include 3D Printing in Biomedical Research, Tissue Engineering and Regenerative Medicine, Cellular Mechanics and Interactions, Pluripotent Stem Cells Research, Neuroscience and Neural Engineering, Cardiomyopathy and Myosin Studies, and Liver physiology and pathology.

Recent notable papers by Christopher S. Chen include:

  • "Mechanical regulation of glycolysis via cytoskeleton architecture," 2020, published in Nature
  • "A multi-organ chip with matured tissue niches linked by vascular flow," 2022, published in Nature Biomedical Engineering
  • "Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy," 2020, published in Circulation
  • "Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study," 2023, published in The Lancet Oncology
  • "Harnessing Mechanobiology for Tissue Engineering," 2021, published in Developmental Cell

The scientist frequently collaborates with a group of co-authors, notably including:

  • Jeroen Eyckmans
  • Jourdan K. Ewoldt
  • Subramanian Sundaram
  • Jonathan G. Seidman
  • Christine E. Seidman

Christopher S. Chen's publications are commonly found in venues such as bioRxiv (Cold Spring Harbor Laboratory), Circulation, arXiv (Cornell University), Cancer Research, and Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature. This distribution indicates a broad engagement with both preprint repositories and peer-reviewed biomedical journals.

Best Publications

  • Geometric control of cell life and death.

    Christopher S. Chen;Milan Mrksich;Sui Huang;George M. Whitesides

  • CELL SHAPE, CYTOSKELETAL TENSION, AND RHOA REGULATE STEM CELL LINEAGE COMMITMENT

    Rowena McBeath;Dana M Pirone;Celeste M Nelson;Kiran Bhadriraju

  • Cells lying on a bed of microneedles: an approach to isolate mechanical force.

    John L. Tan;Joe Tien;Dana M. Pirone;Darren S. Gray

  • Control of stem cell fate by physical interactions with the extracellular matrix.

    Farshid Guilak;Daniel M. Cohen;Bradley T. Estes;Jeffrey M. Gimble

  • Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

    Jordan S. Miller;Kelly R. Stevens;Michael T. Yang;Brendon M. Baker

  • Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

    Andrew J. Maniotis;Christopher S. Chen;Donald E. Ingber

  • Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

    Brendon M. Baker;Christopher S. Chen

  • Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

    Carsten Grashoff;Brenton D. Hoffman;Michael D. Brenner;Ruobo Zhou

  • Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

    Sudhir Khetan;Murat Guvendiren;Wesley R. Legant;Daniel M. Cohen

  • Mechanical regulation of cell function with geometrically modulated elastomeric substrates

    Jianping Fu;Yang Kao Wang;Yang Kao Wang;Michael T. Yang;Ravi A. Desai

  • Emergent patterns of growth controlled by multicellular form and mechanics.

    Celeste M. Nelson;Ronald P. Jean;John L. Tan;Wendy F. Liu

  • Micropatterned Surfaces for Control of Cell Shape, Position, and Function

    Christopher S. Chen;Milan Mrksich;Sui Huang;George M. Whitesides

  • Mechanotransduction in development: a growing role for contractility

    Michele A. Wozniak;Christopher S. Chen

  • Mechanical tugging force regulates the size of cell–cell junctions

    Zhijun Liu;John L. Tan;Daniel M. Cohen;Michael T. Yang

  • Measurement of mechanical tractions exerted by cells in three-dimensional matrices

    Wesley R Legant;Jordan S Miller;Brandon L Blakely;Daniel M Cohen

  • Versatile, Fully Automated, Microfluidic Cell Culture System

    Rafael Gómez-Sjöberg;Anne A Leyrat;Dana M Pirone;Christopher S Chen

  • Nanopattern-induced changes in morphology and motility of smooth muscle cells.

    Evelyn K.F. Yim;Ron M. Reano;Stella W. Pang;Albert F. Yee

  • Cell shape provides global control of focal adhesion assembly.

    Christopher S. Chen;Jose L. Alonso;Emanuele Ostuni;George M. Whitesides

  • Mechanotransduction at Cell-Matrix and Cell-Cell Contacts

    Christopher S. Chen;John Tan;Joe Tien

  • Microcontact printing: A tool to pattern

    Sami Alom Ruiz;Sami Alom Ruiz;Christopher S. Chen

Frequent Co-Authors

Christine E. Seidman
Christine E. Seidman Harvard University
Celeste M. Nelson
Celeste M. Nelson Princeton University
Donald E. Ingber
Donald E. Ingber Harvard University
Jianping Fu
Jianping Fu University of Michigan–Ann Arbor
Jonathan G. Seidman
Jonathan G. Seidman Harvard University
George M. Whitesides
George M. Whitesides Harvard University
Vivek B. Shenoy
Vivek B. Shenoy University of Pennsylvania
Milan Mrksich
Milan Mrksich Northwestern University
Ronald A. Li
Ronald A. Li University of Hong Kong

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