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Biology and Biochemistry

D-Index
67
Citations
19711
World Ranking
8102
National Ranking
623

Overview

Valerie G. Brunton is affiliated with the University of Edinburgh in the United Kingdom. Their research spans multiple fields within the life sciences with a focus on the molecular and cellular mechanisms underlying cancer progression and microenvironments.

The scientist's work contributes notably to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these disciplines, they concentrate on subfields including Molecular Biology, Oncology, Immunology, Genetics, and Immunology and Allergy.

The major topics covered in their publications include:

  • Cell Adhesion Molecules Research
  • Cancer Cells and Metastasis
  • Ubiquitin and proteasome pathways
  • Immune cells in cancer
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Glioma Diagnosis and Treatment
  • Gold and Silver Nanoparticles Synthesis and Applications

Valerie G. Brunton has published research in various scientific venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • The Cambridge Structural Database
  • Cancers

Recent notable publications include:

  • "CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer," 2023, Nature Communications
  • "The fibrotic and immune microenvironments as targetable drivers of metastasis," 2020, British Journal of Cancer
  • "Investigation of cellular uptake mechanism of functionalised gold nanoparticles into breast cancer using SERS," 2020, Chemical Science
  • "A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability," 2021, Cancer Research
  • "Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions," 2021, Cancers

The scientist collaborates frequently with a core group of coauthors, indicating an interdisciplinary and collaborative approach. These frequent coauthors include:

  • Margaret C. Frame
  • Neil O. Carragher
  • John C. Dawson
  • Morwenna Muir
  • Alex von Kriegsheim

Valerie G. Brunton's body of work reflects a multidisciplinary engagement with cancer biology, molecular mechanisms, and nanotechnology applications in biomedical research. Their research covers critical aspects of cancer microenvironments, cell adhesion, immune interactions, and nanoparticle-based methodologies to explore disease processes at a molecular level.

Best Publications

  • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

    Ulrich Wellner;Jörg Schubert;Ulrike C Burk;Otto Schmalhofer

  • The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

    Gordon W. McLean;Neil O. Carragher;Egle Avizienyte;Jeff Evans

  • The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

    Angela M. Krebs;Julia Mitschke;María Lasierra Losada;Otto Schmalhofer

  • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

    Jennifer P. Morton;Paul Timpson;Saadia A. Karim;Rachel A. Ridgway

  • Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

    Michael S. Samuel;Jose I. Lopez;Ewan J. McGhee;Daniel R. Croft

  • E-cadherin-integrin crosstalk in cancer invasion and metastasis.

    Marta Canel;Alan Serrels;Margaret C. Frame;Valerie G. Brunton

  • Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

    Ashley Hamilton;G. Vignir Helgason;Mirle Schemionek;Bin Zhang

  • Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

    Egle Avizienyte;Anne W. Wyke;Robert J. Jones;Gordon W. McLean

  • Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

    Alan Serrels;Tom Lund;Bryan Serrels;Adam Byron

  • CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

    Michal Zimmermann;Olga Murina;Martin A. M. Reijns;Angelo Agathanggelou

  • Integrin signalling regulates YAP and TAZ to control skin homeostasis

    Ahmed Elbediwy;Zoé I. Vincent-Mistiaen;Bradley Spencer-Dene;Richard K. Stone

  • RhoB and Actin Polymerization Coordinate Src Activation with Endosome-Mediated Delivery to the Membrane

    Emma Sandilands;Christophe Cans;Valerie J. Fincham;Valerie G. Brunton

  • Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

    M Agochiya;V G Brunton;D W Owens;E K Parkinson

  • Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

    Bryan Serrels;Alan Serrels;Valerie G. Brunton;Mark Holt

  • Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior.

    Valerie G. Brunton;Egle Avizienyte;Valerie J. Fincham;Bryan Serrels

  • Mouse models of metastasis: progress and prospects.

    Laura Gómez-Cuadrado;Natasha Tracey;Ruoyu Ma;Binzhi Qian;Binzhi Qian

  • AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.

    Samuel H Myers;Valerie G Brunton;Asier Unciti-Broceta

  • Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins

    V J Fincham;M Unlu;V G Brunton;J D Pitts

  • Src and focal adhesion kinase as therapeutic targets in cancer.

    Valerie G Brunton;Margaret C Frame

  • Stimulated Raman scattering microscopy: an emerging tool for drug discovery

    W. J. Tipping;W. J. Tipping;Martin Lee;A. Serrels;V. G. Brunton

Frequent Co-Authors

Margaret C. Frame
Margaret C. Frame University of Edinburgh
Owen J. Sansom
Owen J. Sansom University of Glasgow
Jennifer P. Morton
Jennifer P. Morton University of Glasgow
Paul Timpson
Paul Timpson Garvan Institute of Medical Research
Paul Workman
Paul Workman Institute of Cancer Research
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Tessa L. Holyoake
Tessa L. Holyoake University of Glasgow
Alex von Kriegsheim
Alex von Kriegsheim University of Edinburgh
João F. Passos
João F. Passos Mayo Clinic
William J. Muller
William J. Muller McGill University

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