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D-Index & Metrics

Molecular Biology

D-Index
49
Citations
14701
World Ranking
2600
National Ranking
200

Overview

Alex von Kriegsheim is affiliated with the University of Edinburgh in the United Kingdom and has a significant research output in the fields of biochemistry, genetics, and molecular biology as well as medicine. Their work spans diverse subfields, including molecular biology, cell biology, cancer research, immunology, and oncology.

The scientist has contributed notably to topics such as cancer, hypoxia, and metabolism; RNA modifications and cancer; ubiquitin and proteasome pathways; microtubule and mitosis dynamics; epigenetics and DNA methylation; noise effects and management; and melanoma and MAPK pathways.

Frequent venues for publication include bioRxiv (Cold Spring Harbor Laboratory), where 36 articles have appeared; Nature Communications with 11 publications; Wellcome Open Research and Cancer Research, each with 4 publications; and eLife with 3 publications.

Alex von Kriegsheim has collaborated extensively with several researchers over time. Frequent co-authors include Giovanny Rodriguez Blanco, Roopesh Krishnankutty, Andreas Daiber, Alfonso Bolado-Carrancio, and Adam Byron.

Selected recent papers illustrate the scope of the scientist's interests:

  • Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis, 2020, Cell Metabolism
  • Macrophage fumarate hydratase restrains mtRNA-mediated interferon production, 2023, Nature
  • The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function, 2020, The Journal of Experimental Medicine
  • Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants, 2021, Cell Stem Cell
  • MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease, 2021, Circulation Research

Best Publications

  • Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

    Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson

  • Raf Family Kinases: Old Dogs Have Learned New Tricks

    David Matallanas;Marc Birtwistle;David Romano;Armin Zebisch

  • Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

    Alan Serrels;Tom Lund;Bryan Serrels;Adam Byron

  • CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

    Matthew D. Smith;Margaret E. Harley;Alain J. Kemp;Jimi Wills

  • Cell fate decisions are specified by the dynamic ERK interactome

    Alex von Kriegsheim;Daniela Baiocchi;Marc Birtwistle;David Sumpton

  • Towards complete analysis of the platelet proteome.

    Eric E. O’Neill;Chris J. Brock;Alexander F. von Kriegsheim;Andrew C. Pearce

  • Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

    Pranvera Sadiku;Pranvera Sadiku;Joseph A. Willson;Eilise M. Ryan;David Sammut

  • Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

    Lorenzo Rinaldi;Debayan Datta;Judit Serrat;Lluis Morey

  • Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5

    Alex von Kriegsheim;Andrew Pitt;G. Joan Grindlay;Walter Kolch

  • Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

    Carsten C. Scholz;Miguel A.S. Cavadas;Murtaza M. Tambuwala;Murtaza M. Tambuwala;Emily Hams

  • Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

    Kate M. Byrne;Naser Monsefi;John C. Dawson;Andrea Degasperi

  • On-Beads Digestion in Conjunction with Data-Dependent Mass Spectrometry: A Shortcut to Quantitative and Dynamic Interaction Proteomics

    Benedetta Turriziani;Amaya Garcia-Munoz;Ruth Pilkington;Cinzia Raso

  • Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.

    Tian-Rui Xu;Vladislav Vyshemirsky;Amélie Gormand;Alex von Kriegsheim

  • Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

    Paul Timpson;Ewan J. McGhee;Jennifer P. Morton;Alex von Kriegsheim

  • RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

    Guillaume Jacquemet;David M. Green;Rebecca E. Bridgewater;Alexander von Kriegsheim

  • BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

    Gabrielle Olley;Morad Ansari;Hemant Bengani;Graeme R Grimes

  • The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

    Christopher Mapperley;Christopher Mapperley;Louie Van De Lagemaat;Louie Van De Lagemaat;Hannah Lawson;Andrea Tavosanis

  • Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

    Congshan Sun;Vanessa De Mello;Abdalla Mohamed;Huascar P. Ortuste Quiroga

  • ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

    James Monypenny;Hanna Milewicz;Fabian Flores-Borja;Gregory Weitsman

  • Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

    Miguel Cavadas;Ioanna Oikonomidi;Catarina J. Gaspar;Emma Burbridge

Frequent Co-Authors

Walter Kolch
Walter Kolch University College Dublin
Boris N. Kholodenko
Boris N. Kholodenko University College Dublin
Valerie G. Brunton
Valerie G. Brunton University of Edinburgh
Cormac T. Taylor
Cormac T. Taylor University College Dublin
Owen J. Sansom
Owen J. Sansom University of Glasgow
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Alan Ashworth
Alan Ashworth University of California, San Francisco
David R. FitzPatrick
David R. FitzPatrick University of Edinburgh

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