Boris N. Kholodenko

Research.com Recognitions

• 2018 - Member of the Royal Irish Academy

Overview

Best Publications

• Cell-signalling dynamics in time and space

  Boris N. Kholodenko

  1602
  Citations

• Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

  Nick I. Markevich;Jan B. Hoek;Boris N. Kholodenko

  847
  Citations

• Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades.

  Boris N. Kholodenko

  844
  Citations

• Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

  Boris N. Kholodenko;Oleg V. Demin;Gisela Moehren;Jan B. Hoek

  833
  Citations

• Signalling ballet in space and time

  Boris N. Kholodenko;John F. Hancock;Walter Kolch

  720
  Citations

• Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.

  Edita Aksamitiene;Anatoly B. Kiyatkin;Boris N. Kholodenko;Boris N. Kholodenko

  550
  Citations

• Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

  Boris N. Kholodenko;Anatoly Kiyatkin;Frank J. Bruggeman;Eduardo Sontag

  503
  Citations

• The dynamic control of signal transduction networks in cancer cells.

  Walter Kolch;Melinda Halasz;Marina Granovskaya;Boris N. Kholodenko

  348
  Citations

• Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses

  Marc R Birtwistle;Marc R Birtwistle;Mariko Hatakeyama;Noriko Yumoto;Babatunde A Ogunnaike

  304
  Citations

• The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

  Oliver E. Sturm;Richard Orton;Joan Grindlay;Marc Birtwistle

  302
  Citations

• Quantitative analysis of signaling networks

  Herbert M. Sauro;Boris N. Kholodenko

  288
  Citations

• Why cytoplasmic signalling proteins should be recruited to cell membranes

  Boris N. Kholodenko;Jan B. Hoek;Hans V. Westerhoff

  284
  Citations

• Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

  Takashi Nakakuki;Marc R. Birtwistle;Marc R. Birtwistle;Marc R. Birtwistle;Yuko Saeki;Noriko Yumoto

  282
  Citations

• Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling

  Nikolay Borisov;Edita Aksamitiene;Anatoly Kiyatkin;Stefan Legewie

  273
  Citations

• Spatial gradients of cellular phospho-proteins.

  Guy C. Brown;Boris N. Kholodenko

  247
  Citations

• Frequency modulation of ERK activation dynamics rewires cell fate

  Hyunryul Ryu;Minhwan Chung;Maciej Dobrzyński;Dirk Fey

  242
  Citations

• Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

  Anatoly Kiyatkin;Edita Aksamitiene;Nick I. Markevich;Nikolay M. Borisov

  233
  Citations

• Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data

  Eduardo Sontag;Anatoly Kiyatkin;Boris N. Kholodenko

  232
  Citations

• Evaluating strategies to normalise biological replicates of Western blot data.

  Andrea Degasperi;Marc R. Birtwistle;Natalia Volinsky;Jens Rauch

  221
  Citations

• Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.

  Boris N Kholodenko

  216
  Citations