Jan B. Hoek

Overview

Best Publications

• Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

  Nick I. Markevich;Jan B. Hoek;Boris N. Kholodenko

  847
  Citations

• Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

  Boris N. Kholodenko;Oleg V. Demin;Gisela Moehren;Jan B. Hoek

  833
  Citations

• Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis

  John G. Pastorino;Nataly Shulga;Jan B. Hoek

  820
  Citations

• Ethanol, oxidative stress, and cytokine-induced liver cell injury

  Jan B. Hoek;John G. Pastorino

  635
  Citations

• Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.

  Kenneth D. Chavin;ShiQi Yang;Hui Zhi Lin;John Chatham

  597
  Citations

• Alcohol and mitochondria: a dysfunctional relationship.

  Jan B. Hoek;Alan Cahill;John G. Pastorino

  584
  Citations

• Activation of Glycogen Synthase Kinase 3β Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity

  John G. Pastorino;Jan B. Hoek;Nataly Shulga

  548
  Citations

• Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

  Boris N. Kholodenko;Anatoly Kiyatkin;Frank J. Bruggeman;Eduardo Sontag

  503
  Citations

• Role of calcium in the hormonal regulation of liver metabolism

  John R. Williamson;Ronald H. Cooper;Jan B. Hoek

  444
  Citations

• Regulation of hexokinase binding to VDAC.

  John G. Pastorino;Jan B. Hoek

  435
  Citations

• Physiological roles of nicotinamide nucleotide transhydrogenase.

  J B Hoek;J Rydström

  403
  Citations

• Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

  John G. Pastorino;Marco Tafani;Ronald J. Rothman;Ausra Marcineviciute

  375
  Citations

• Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition.

  J G Pastorino;J W Snyder;A Serroni;J B Hoek

  346
  Citations

• Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses

  Marc R Birtwistle;Marc R Birtwistle;Mariko Hatakeyama;Noriko Yumoto;Babatunde A Ogunnaike

  304
  Citations

• Determination of the mitochondrial protonmotive force in isolated hepatocytes.

  Jan B. Hoek;David G. Nicholls;John R. Williamson

  301
  Citations

• Hexokinase II: the integration of energy metabolism and control of apoptosis.

  John G Pastorino;Jan B Hoek

  296
  Citations

• Why cytoplasmic signalling proteins should be recruited to cell membranes

  Boris N. Kholodenko;Jan B. Hoek;Hans V. Westerhoff

  284
  Citations

• Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling

  Nikolay Borisov;Edita Aksamitiene;Anatoly Kiyatkin;Stefan Legewie

  273
  Citations

• Ethanol and signal transduction in the liver.

  Jan B. Hoek;Andrew P. Thomas;Thomas A. Rooney;Katsuyoshi Higashi

  236
  Citations

• Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

  Anatoly Kiyatkin;Edita Aksamitiene;Nick I. Markevich;Nikolay M. Borisov

  233
  Citations