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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
98
Citations
44132
World Ranking
1633
National Ranking
102

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Guy C. Brown is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on the fields of Neuroscience, Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology.

The scientist's main subfields of study include Neurology, Immunology, Physiology, Molecular Biology, and Biological Psychiatry. Their work covers a range of topics, with particular emphasis on:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Adenosine and Purinergic Signaling
  • Immune cells in cancer
  • Inflammation biomarkers and pathways
  • Phagocytosis and Immune Regulation
  • Galectins and Cancer Biology

Guy C. Brown has published extensively in several scientific journals. Their most frequent publication venues include:

  • Journal of Neurochemistry
  • Frontiers in Immunology
  • Frontiers in Aging Neuroscience
  • Nature reviews. Immunology
  • Frontiers in Cellular Neuroscience

Recent papers authored or co-authored by Guy C. Brown demonstrate a focus on neuroinflammation, microglial function, and neurodegeneration:

  • Microglia states and nomenclature: A field at its crossroads (2022, Neuron)
  • Microglial phagocytosis of neurons in neurodegeneration, and its regulation (2021, Journal of Neurochemistry)
  • Neuroinflammation in Alzheimer disease (2024, Nature reviews. Immunology)
  • Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration (2020, Frontiers in Cellular Neuroscience)
  • The Phagocytic Code Regulating Phagocytosis of Mammalian Cells (2021, Frontiers in Immunology)

Throughout their career, Guy C. Brown has collaborated repeatedly with several co-authors, including:

  • David H. Allendorf
  • Mar Puigdellívol
  • Jacob M. Dundee
  • Anna Vilalta
  • Peter St George-Hyslop

Best Publications

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • Cellular energy utilization and molecular origin of standard metabolic rate in mammals

    D. F. S. Rolfe;G. C. Brown

  • Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

    Guy C. Brown;Chris.E. Cooper

  • Neuronal Cell Death.

    Michael Fricker;Abby Miriam Tolkovsky;Vilmante Borutaite;Michael Philip Coleman

  • Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione

    Emilio Clementi;Guy Charles Brown;Martin Feelisch;Salvador Moncada

  • Nitric oxide and mitochondrial respiration.

    Guy C Brown

  • The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance

    Chris E. Cooper;Guy C. Brown

  • Microglial phagocytosis of live neurons

    Guy C. Brown;Jonas J. Neher

  • Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity

    Anna Bal-Price;Guy C. Brown

  • Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase.

    Guy C. Brown

  • Control of respiration and ATP synthesis in mammalian mitochondria and cells.

    G C Brown

  • Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

    Guy C. Brown

  • Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy

    Ann Lorek;Y Takei;E B Cady;J S Wyatt

  • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons.

    Guy C. Brown;Jonas J. Neher

  • Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria.

    Guy C. Brown;Anna Bal-Price

  • Nitric oxide and neuronal death

    Guy C. Brown

  • Nitric oxide inhibition of mitochondrial respiration and its role in cell death.

    Guy C Brown;Vilmante Borutaite

  • Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet.

    Marianne Thoresen;Juliet Penrice;Ann Lorek;E B Cady

  • On the mechanism by which vascular endothelial cells regulate their oxygen consumption

    Emilio Clementi;Guy Charles Brown;Neale Foxwell;Salvador Moncada

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

Chris E. Cooper
Chris E. Cooper University of Essex
Martin D. Brand
Martin D. Brand Buck Institute for Research on Aging
Boris N. Kholodenko
Boris N. Kholodenko University College Dublin
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
José L. Venero
José L. Venero University of Seville
Salvador Moncada
Salvador Moncada University of Manchester
Hans V. Westerhoff
Hans V. Westerhoff Vrije Universiteit Amsterdam
Jan B. Hoek
Jan B. Hoek Thomas Jefferson University
Javier Vitorica
Javier Vitorica University of Seville
Alexei Verkhratsky
Alexei Verkhratsky University of Manchester

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