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D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
42227
World Ranking
5183
National Ranking
2465

Overview

Paul S. Brookes is affiliated with the University of Rochester Medical Center in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with substantial contributions also in medicine. Subfields of study include molecular biology, physiology, pathology and forensic medicine, cancer research, and cardiology and cardiovascular medicine.

The central topics of their work encompass mitochondrial function and pathology, cardiac ischemia and reperfusion, cancer, hypoxia, and metabolism, diet and metabolism studies, ATP synthase and ATPases research, adipose tissue and metabolism, and electron spin resonance studies.

Among recent publications, Paul S. Brookes contributed to several peer-reviewed articles including:

  • "Cardiac metabolism as a driver and therapeutic target of myocardial infarction," 2020, Journal of Cellular and Molecular Medicine
  • "The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function," 2020, Nature Communications
  • "Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites," 2022, Arthritis & Rheumatology
  • "Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury," 2020, Redox Biology
  • "Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation," 2022, Journal of the American Heart Association

Frequent collaborators include Sergiy M. Nadtochiy, Alexander S. Milliken, Chaitanya A. Kulkarni, Ethan D. Cohen, and George A. Porter. The partnerships with these researchers have resulted in multiple joint publications.

Paul S. Brookes publishes regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Redox Biology, eLife, arXiv (Cornell University), and Free Radical Biology and Medicine. The range of journals reflects a multidisciplinary approach involving molecular mechanisms, redox biology, and translational research.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Calcium, ATP, and ROS: a mitochondrial love-hate triangle

    Paul S. Brookes;Yisang Yoon;James L. Robotham;M. W. Anders

  • Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

    Edward T. Chouchani;Edward T. Chouchani;Victoria R. Pell;Edoardo Gaude;Dunja Aksentijević

  • BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.

    Eleni D. Lagadinou;Alexander Sach;Kevin Callahan;Randall M. Rossi

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

    Edward T Chouchani;Carmen Methner;Sergiy M Nadtochiy;Angela Logan

  • Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

    Sruti Shiva;Michael N. Sack;James J. Greer;Mark Duranski

  • Nitric oxide, mitochondria and neurological disease.

    Simon J.R. Heales;Juan P. Bolaños;Victoria C. Stewart;Paul S. Brookes

  • Mitochondrial H(+) leak and ROS generation: an odd couple.

    Paul S. Brookes

  • The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

    Martin D. Brand;Julian L. Pakay;Augustine Ocloo;Jason Kokoszka

  • Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release.

    Paul S. Brookes;Emmanuel Padilla Salinas;Kenta Darley-Usmar;Jason P. Eiserich

  • Direct evidence for S-nitrosation of mitochondrial complex I

    Lindsay S. Burwell;Sergiy M. Nadtochiy;Andrew J. Tompkins;Sara Young

  • Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.

    Paul S. Brookes;Anna-Liisa Levonen;Sruti Shiva;Paolo Sarti

  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

    Vishal M Gohil;Sunil A Sheth;Sunil A Sheth;Roland Nilsson;Roland Nilsson;Andrew P Wojtovich

  • SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

    Samuel Caito;Saravanan Rajendrasozhan;Suzanne Cook;Sangwoon Chung

  • The Proton Permeability of the Inner Membrane of Liver Mitochondria from Ectothermic and Endothermic Vertebrates and from Obese Rats: Correlations with Standard Metabolic Rate and Phospholipid Fatty Acid Composition

    Paul S Brookes;Julie A Buckingham;Ana Maria Tenreiro;A.J Hulbert

  • Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy

    Andrew M. Walters;George A. Porter;Paul S. Brookes

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase.

    Sruti Shiva;Paul S. Brookes;Rakesh P. Patel;Peter G. Anderson

Frequent Co-Authors

Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Shey-Shing Sheu
Shey-Shing Sheu Thomas Jefferson University
Evelina Gatti
Evelina Gatti Aix-Marseille University
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Robert T. Dirksen
Robert T. Dirksen University of Rochester
Sergio Lavandero
Sergio Lavandero University of Chile
Simon J. R. Heales
Simon J. R. Heales University College London
Michael A. O'Reilly
Michael A. O'Reilly The University of Texas MD Anderson Cancer Center
Michael P. Murphy
Michael P. Murphy University of Cambridge
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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