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Francisco J. Schopfer

Francisco J. Schopfer

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
12137
World Ranking
13803
National Ranking
5840

Overview

Francisco J. Schopfer is affiliated with the University of Pittsburgh in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, biochemistry, physiology, cancer research, and plant science as prominent subfields.

The scientist's work has contributed to several topics including eicosanoids and hypertension pharmacology, cancer, lipids, and metabolism, metabolomics and mass spectrometry studies, fatty acid research and health, diet, metabolism and disease, hemoglobinopathies and related disorders, and DNA repair mechanisms.

Francisco J. Schopfer has published extensively in various journals. Notable recent papers include:

  • Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase (2023, Science)
  • Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages (2020, Redox Biology)
  • Nitro-oleic acid triggers ROS production via NADPH oxidase activation in plants: A pharmacological approach (2020, Journal of Plant Physiology)
  • Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation (2021, Redox Biology)
  • Mass spectrometry-based study defines the human urine nitrolipidome (2020, Free Radical Biology and Medicine)

Frequent co-authors collaborating with Schopfer include Sonia R. Salvatore, Bruce Α. Freeman, Adam C. Straub, Fei Chang, and Darío A. Vitturi. This collaboration network reflects ongoing work in fields related to redox biology and lipid signaling.

Their research has appeared most often in journals such as Free Radical Biology and Medicine, bioRxiv (Cold Spring Harbor Laboratory), Redox Biology, JCI Insight, and the Journal of Clinical Investigation, illustrating a focus on biochemistry and molecular mechanisms in health and disease contexts.

Best Publications

  • NITRIC OXIDE INHIBITS ELECTRON TRANSFER AND INCREASES SUPEROXIDE RADICAL PRODUCTION IN RAT HEART MITOCHONDRIA AND SUBMITOCHONDRIAL PARTICLES

    Juan José Poderoso;Marı́a Cecilia Carreras;Constanza Lisdero;Natalia Riobó

  • Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor γ ligand

    Francisco J. Schopfer;Yiming Lin;Paul R. S. Baker;Taixing Cui

  • Fatty Acid Transduction of Nitric Oxide Signaling MULTIPLE NITRATED UNSATURATED FATTY ACID DERIVATIVES EXIST IN HUMAN BLOOD AND URINE AND SERVE AS ENDOGENOUS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR LIGANDS

    Paul R.S. Baker;Yiming Lin;Francisco J. Schopfer;Steven R. Woodcock

  • NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

    Francisco J. Schopfer;Paul R.S. Baker;Bruce A. Freeman

  • Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators

    Taixing Cui;Francisco J. Schopfer;Jifeng Zhang;Kai Chen

  • Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

    Alison L Groeger;Chiara Cipollina;Marsha P Cole;Steven R Woodcock

  • Reversible post-translational modification of proteins by nitrated fatty acids in vivo

    Carlos Batthyany;Francisco J. Schopfer;Paul R. S. Baker;Rosario Durán

  • Formation and signaling actions of electrophilic lipids.

    Francisco J. Schopfer;Chiara Cipollina;Bruce A. Freeman

  • Nitro-fatty acid formation and signaling

    Bruce A. Freeman;Paul R. S. Baker;Francisco J. Schopfer;Steven R. Woodcock

  • Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

    Anne-Louise Smidt Hansen;Gregory J. Buchan;Michael Rühl;Kojiro Mukai

  • Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation

    Paul R. S. Baker;Francisco J. Schopfer;Scott Sweeney;Bruce A. Freeman

  • Molecular recognition of nitrated fatty acids by PPAR gamma.

    Yong Li;Yong Li;Jifeng Zhang;Francisco J Schopfer;Dariusz Martynowski

  • The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol.

    Juan José Poderoso;Constanza Lisdero;Francisco Schöpfer;Natalia Riobó

  • Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction.

    Laura M.S. Baker;Paul R.S. Baker;Franca Golin-Bisello;Francisco J. Schopfer

  • Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

    Emilia Kansanen;Gustavo Bonacci;Francisco J. Schopfer;Suvi M. Kuosmanen

  • Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.

    Volker Rudolph;Volker Rudolph;Tanja K. Rudolph;Tanja K. Rudolph;Francisco J. Schopfer;Gustavo Bonacci

  • Fatty Acid Transduction of Nitric Oxide Signaling NITROLINOLEIC ACID IS A HYDROPHOBICALLY STABILIZED NITRIC OXIDE DONOR

    Francisco J. Schopfer;Paul R.S. Baker;Gregory Giles;Phil Chumley

  • Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart

    Juan J. Poderoso;Jorge G. Peralta;Constanza L. Lisdero;Maria Cecilia Carreras

  • Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS

    Francisco J. Schopfer;Marsha P. Cole;Alison L. Groeger;Chen Shan Chen

  • The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance.

    Juan José Poderoso;María Cecilia Carreras;Francisco Schöpfer;Constanza L. Lisdero

Frequent Co-Authors

Bruce A. Freeman
Bruce A. Freeman University of Pittsburgh
Jifeng Zhang
Jifeng Zhang University of Michigan–Ann Arbor
Y. Eugene Chen
Y. Eugene Chen University of Michigan–Ann Arbor
Rafael Radi
Rafael Radi University of the Republic
Juan B. Barroso
Juan B. Barroso University of Jaén
Alberto Boveris
Alberto Boveris University of Buenos Aires
Thomas W. Kensler
Thomas W. Kensler Johns Hopkins University
Beatriz Alvarez
Beatriz Alvarez University of the Republic
Valerie B. O'Donnell
Valerie B. O'Donnell Cardiff University
Enrique Cadenas
Enrique Cadenas University of Southern California

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