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Takaaki Akaike

Takaaki Akaike

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
30127
World Ranking
2026
National Ranking
117

Overview

Takaaki Akaike is affiliated with Tohoku University in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, along with medicine. Their scholarly work primarily encompasses the subfields of biochemistry, molecular biology, physiology, immunology, and rheumatology.

Their research topics largely focus on sulfur compounds in biology, redox biology and oxidative stress, genomics related to phytochemicals and oxidative stress, glutathione transferases and polymorphisms, folate and B vitamins research, air quality and health impacts, and the role of heme oxygenase-1 and carbon monoxide.

Recent notable publications include:

  • Control of protein function through oxidation and reduction of persulfidated states, 2020, Science Advances
  • Sulfide catabolism ameliorates hypoxic brain injury, 2021, Nature Communications
  • Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation, 2021, Proceedings of the National Academy of Sciences
  • Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides, 2020, Biomolecules
  • PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis, 2024, Nature Structural & Molecular Biology

Akaike has frequently published in several key scientific venues, including:

  • Redox Biology
  • Free Radical Biology and Medicine
  • Antioxidants and Redox Signaling
  • Science Advances
  • Nature Communications

Collaborations form an important part of Akaike's work, with frequent coauthors including Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi, and Motohiro Nishida.

Best Publications

  • Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

    Tomoaki Ida;Tomohiro Sawa;Hideshi Ihara;Yukihiro Tsuchiya

  • Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.

    Takaaki Akaike;Masaki Yoshida;Yoichi Miyamoto;Keizo Sato

  • Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals

    Takaaki Akaike;Yoichiro Noguchi;Sumiko Ijiri;Keisuke Setoguchi

  • Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

    H Maeda;T Akaike

  • Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

    Youichiro Noguchi;Jun Wu;Ruth Duncan;Jiří Strohalm

  • Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD

    Tatsuya Oda;Takaaki Akaike;Takayoshi Hamamoto;Fujio Suzuki

  • Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

    Takaaki Akaike;Tomoaki Ida;Fan-Yan Wei;Motohiro Nishida;Motohiro Nishida

  • Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation

    Tatsuya Okamoto;Tatsuya Okamoto;Takaaki Akaike;Tomohiro Sawa;Yoichi Miyamoto

  • Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.

    Tomohiro Sawa;Mayumi Nakao;Takaaki Akaike;Kanji Ono

  • Nitric oxide and virus infection.

    T. Akaike;H. Maeda

  • Keap1 degradation by autophagy for the maintenance of redox homeostasis

    Keiko Taguchi;Nanako Fujikawa;Masaaki Komatsu;Tetsuro Ishii

  • Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.

    Takaaki Akaike;Masayuki Ando;Tatsuya Oda;Toshinori Doi

  • AUTACs: Cargo-Specific Degraders Using Selective Autophagy.

    Daiki Takahashi;Jun Moriyama;Tomoe Nakamura;Erika Miki

  • Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.

    D. Craig Hooper;Omar Bagasra;Joseph C. Marini;Anna Zborek

  • Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

    Katsuhiko Ono;Takaaki Akaike;Tomohiro Sawa;Yoshito Kumagai

  • Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

    Motohiro Nishida;Tomohiro Sawa;Naoyuki Kitajima;Katsuhiko Ono

  • Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

    Hiroshi Maeda;Youichiro Noguchi;Keizo Sato;Takaaki Akaike

  • Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

    Tatsuya Okamoto;Takaaki Akaike;Tetsuo Nagano;Seiya Miyajima

  • In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

    Jun Fang;Tomohiro Sawa;Tomohiro Sawa;Takaaki Akaike;Teruo Akuta

  • Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

    Tomohiro Sawa;Mohammad Hasan Zaki;Tatsuya Okamoto;Teruo Akuta

Frequent Co-Authors

Hiroshi Maeda
Hiroshi Maeda Kumamoto University
Yoshito Kumagai
Yoshito Kumagai University of Tsukuba
Masaki Otagiri
Masaki Otagiri Sojo University
Hozumi Motohashi
Hozumi Motohashi Tohoku University
Motohiro Nishida
Motohiro Nishida Kyushu University
Jon M. Fukuto
Jon M. Fukuto Sonoma State University
Masayuki Ando
Masayuki Ando Kumamoto University
Toru Maruyama
Toru Maruyama Kumamoto University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Yoshiaki Kawamura
Yoshiaki Kawamura Aichi Gakuin University

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