World's Best Scientists 2026 revealed!
Takaaki Akaike

Takaaki Akaike

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
30127
World Ranking
2026
National Ranking
117

Takaaki Akaike publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Takaaki Akaike sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 391 publications — 89th percentile

89% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Takaaki Akaike D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Takaaki Akaike sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 94 D-Index — 90th percentile

90% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Takaaki Akaike is affiliated with Tohoku University in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, along with medicine. Their scholarly work primarily encompasses the subfields of biochemistry, molecular biology, physiology, immunology, and rheumatology.

Their research topics largely focus on sulfur compounds in biology, redox biology and oxidative stress, genomics related to phytochemicals and oxidative stress, glutathione transferases and polymorphisms, folate and B vitamins research, air quality and health impacts, and the role of heme oxygenase-1 and carbon monoxide.

Recent notable publications include:

  • Control of protein function through oxidation and reduction of persulfidated states, 2020, Science Advances
  • Sulfide catabolism ameliorates hypoxic brain injury, 2021, Nature Communications
  • Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation, 2021, Proceedings of the National Academy of Sciences
  • Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides, 2020, Biomolecules
  • PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis, 2024, Nature Structural & Molecular Biology

Akaike has frequently published in several key scientific venues, including:

  • Redox Biology
  • Free Radical Biology and Medicine
  • Antioxidants and Redox Signaling
  • Science Advances
  • Nature Communications

Collaborations form an important part of Akaike's work, with frequent coauthors including Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi, and Motohiro Nishida.

Best Publications

  • Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

    Tomoaki Ida;Tomohiro Sawa;Hideshi Ihara;Yukihiro Tsuchiya

  • Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.

    Takaaki Akaike;Masaki Yoshida;Yoichi Miyamoto;Keizo Sato

  • Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals

    Takaaki Akaike;Yoichiro Noguchi;Sumiko Ijiri;Keisuke Setoguchi

  • Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

    H Maeda;T Akaike

  • Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues

    Youichiro Noguchi;Jun Wu;Ruth Duncan;Jiří Strohalm

  • Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD

    Tatsuya Oda;Takaaki Akaike;Takayoshi Hamamoto;Fujio Suzuki

  • Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

    Takaaki Akaike;Tomoaki Ida;Fan-Yan Wei;Motohiro Nishida;Motohiro Nishida

  • Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation

    Tatsuya Okamoto;Tatsuya Okamoto;Takaaki Akaike;Tomohiro Sawa;Yoichi Miyamoto

  • Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.

    Tomohiro Sawa;Mayumi Nakao;Takaaki Akaike;Kanji Ono

  • Nitric oxide and virus infection.

    T. Akaike;H. Maeda

  • Keap1 degradation by autophagy for the maintenance of redox homeostasis

    Keiko Taguchi;Nanako Fujikawa;Masaaki Komatsu;Tetsuro Ishii

  • Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.

    Takaaki Akaike;Masayuki Ando;Tatsuya Oda;Toshinori Doi

  • AUTACs: Cargo-Specific Degraders Using Selective Autophagy.

    Daiki Takahashi;Jun Moriyama;Tomoe Nakamura;Erika Miki

  • Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.

    D. Craig Hooper;Omar Bagasra;Joseph C. Marini;Anna Zborek

  • Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

    Katsuhiko Ono;Takaaki Akaike;Tomohiro Sawa;Yoshito Kumagai

  • Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

    Motohiro Nishida;Tomohiro Sawa;Naoyuki Kitajima;Katsuhiko Ono

  • Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

    Hiroshi Maeda;Youichiro Noguchi;Keizo Sato;Takaaki Akaike

  • Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

    Tatsuya Okamoto;Takaaki Akaike;Tetsuo Nagano;Seiya Miyajima

  • In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

    Jun Fang;Tomohiro Sawa;Tomohiro Sawa;Takaaki Akaike;Teruo Akuta

  • Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

    Tomohiro Sawa;Mohammad Hasan Zaki;Tatsuya Okamoto;Teruo Akuta

Frequent Co-Authors

Hiroshi Maeda
Hiroshi Maeda Kumamoto University
Yoshito Kumagai
Yoshito Kumagai University of Tsukuba
Masaki Otagiri
Masaki Otagiri Sojo University
Hozumi Motohashi
Hozumi Motohashi Tohoku University
Motohiro Nishida
Motohiro Nishida Kyushu University
Jon M. Fukuto
Jon M. Fukuto Sonoma State University
Masayuki Ando
Masayuki Ando Kumamoto University
Toru Maruyama
Toru Maruyama Kumamoto University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Yoshiaki Kawamura
Yoshiaki Kawamura Aichi Gakuin University

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