World's Best Scientists 2026 revealed!
Award Badge
Chemistry
Uruguay
2025

D-Index & Metrics

Chemistry

D-Index
114
Citations
50537
World Ranking
668
National Ranking
1

Biology and Biochemistry

D-Index
115
Citations
52289
World Ranking
784
National Ranking
1

Research.com Recognitions

  • 2025 - Research.com Chemistry in Uruguay Leader Award
  • 2015 - Member of the National Academy of Sciences
  • 2004 - Fellow, The World Academy of Sciences
  • 2003 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Rafael Radi is affiliated with the University of the Republic in Uruguay and has a significant body of work primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research output includes 117 publications in biochemistry and related molecular life sciences, complemented by 99 contributions within medical research.

The scientist's work spans multiple subfields, including Molecular Biology, Physiology, Biochemistry, Epidemiology, and Public Health, Environmental and Occupational Health. Key research topics addressed include:

  • Redox biology and oxidative stress
  • Nitric Oxide and Endothelin Effects
  • Trypanosoma species research and implications
  • Sulfur Compounds in Biology
  • Research on Leishmaniasis Studies
  • Mitochondrial Function and Pathology
  • Electron Spin Resonance Studies

Rafael Radi's research has been published in numerous venues, with frequent appearances in:

  • Free Radical Biology and Medicine (55 publications)
  • Proceedings of the National Academy of Sciences (5 publications)
  • Journal of Biological Chemistry (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Redox Biochemistry and Chemistry (4 publications)

Recent publications exemplify the scientist's focus on oxidative stress and cellular signaling processes. Selected papers include:

  • "Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo," 2022, Nature Metabolism
  • "The superoxide radical switch in the biology of nitric oxide and peroxynitrite," 2022, Physiological Reviews
  • "3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function," 2020, Essays in Biochemistry
  • "Hypoxic-Ischemic Encephalopathy and Mitochondrial Dysfunction: Facts, Unknowns, and Challenges," 2020, Antioxidants and Redox Signaling
  • "The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity," 2021, Proceedings of the National Academy of Sciences

Collaborations are an important aspect of Rafael Radi's work. Frequent co-authors include:

  • Mauricio Mastrogiovanni
  • Lucía Piacenza
  • Ari Zeida
  • Silvina Bartesaghi
  • Natalia Ríos

Throughout their career, Rafael Radi has received several recognitions including membership in the National Academy of Sciences since 2015. Other fellowships include The World Academy of Sciences awarded in 2004 and a fellowship from the John Simon Guggenheim Memorial Foundation received in 2003.

Best Publications

  • Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide

    Rafael Radi;Joseph S. Beckman;Kenneth M. Bush;Bruce A. Freeman

  • Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

    Csaba Szabó;Csaba Szabó;Harry Ischiropoulos;Rafael Radi

  • Nitric oxide, oxidants, and protein tyrosine nitration

    Rafael Radi

  • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.

    H Rubbo;R Radi;M Trujillo;R Telleri

  • Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

    Unknown

  • Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

    Rafael Radi

  • Peroxynitrite, a stealthy biological oxidant

    Rafael Radi

  • Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport.

    Adriana Cassina;Rafael Radi

  • Unraveling peroxynitrite formation in biological systems.

    Rafael Radi;Gonzalo Peluffo;Marı́a Noel Alvarez;Mercedes Naviliat

  • Inhibition of Mitochondrial Electron Transport by Peroxynitrite

    R Radi;M Rodriguez;L Castro;R Telleri

  • Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

    Gerardo Ferrer-Sueta;Rafael Radi

  • Peroxynitrite reactions and formation in mitochondria.

    Rafael Radi;Adriana Cassina;Roberto Hodara;Celia Quijano

  • The thiol pool in human plasma: the central contribution of albumin to redox processes.

    Lucía Turell;Rafael Radi;Beatriz Alvarez

  • Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

    L Castro;M Rodriguez;R Radi

  • Peroxynitrite reactivity with amino acids and proteins.

    B. Alvarez;R. Radi

  • Detection of catalase in rat heart mitochondria.

    R. Radi;J. F. Turrens;Ling Yi Chang;K. M. Bush

  • Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

    Ana Denicola;Bruce A. Freeman;Madia Trujillo;Rafael Radi

  • Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects.

    Rafael Radi

  • Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.

    Gerardo Ferrer-Sueta;Nicolás Campolo;Madia Trujillo;Silvina Bartesaghi

  • Diffusion of peroxynitrite across erythrocyte membranes

    Ana Denicola;José M. Souza;Rafael Radi

  • Protein tyrosine nitration--functional alteration or just a biomarker?

    José M. Souza;Gonzalo Peluffo;Rafael Radi

Frequent Co-Authors

Madia Trujillo
Madia Trujillo University of the Republic
Bruce A. Freeman
Bruce A. Freeman University of Pittsburgh
Beatriz Alvarez
Beatriz Alvarez University of the Republic
Ana Denicola
Ana Denicola University of the Republic
Darío A. Estrin
Darío A. Estrin University of Buenos Aires
Daniel H. Murgida
Daniel H. Murgida University of Buenos Aires
Ohara Augusto
Ohara Augusto Universidade de São Paulo
Ines Batinic-Haberle
Ines Batinic-Haberle Duke University
Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Joseph S. Beckman
Joseph S. Beckman Oregon State University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens doors to various exciting career paths, many of which can be pursued through specialized online degrees. For example, becoming a pharmacist involves a deep understanding of chemical compounds and their applications. Prospective students can explore the pharmacist salary and career outlook to see the benefits of this profession.

For those interested in forensic science, becoming an autopsy tech is a critical role that combines chemistry knowledge with anatomy. If this career path appeals to you, it’s helpful to review what it takes to become an autopsy tech, including education requirements and job outlook, as detailed in this guide on autopsy tech.

Many students also seek flexibility through the best online colleges for forensic science programs, which provide essential skills for crime scene analysis, laboratory work, and more. These programs are designed to fit different schedules while maintaining rigorous training in chemistry and forensic techniques.

Additionally, pursuing an online forensic psychology masters allows chemistry graduates to delve into the psychological aspects of criminal behavior, complementing their scientific knowledge with behavioral insights.

Best Scientists Citing Rafael Radi

Trending Scientists