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Ivan Spasojevic

Ivan Spasojevic

D-Index & Metrics

Chemistry

D-Index
66
Citations
13630
World Ranking
7398
National Ranking
2184

Overview

Ivan Spasojevic is affiliated with Duke University in the United States and has contributed extensively to medical and biochemical research. Their work spans several disciplines, with a primary focus on medicine and biochemistry, genetics, and molecular biology. Across these fields, they have produced numerous publications reflecting their engagement with complex biomedical challenges.

The scientist's research interests are varied but show particular concentration in molecular biology, oncology, pulmonary and respiratory medicine, genetics, and pediatrics, perinatology, and child health. Their main topics of work include glioma diagnosis and treatment, nanoparticle-based drug delivery, neuroinflammation and neurodegeneration mechanisms, birth, development, and health, monoclonal and polyclonal antibodies research, vitamin C and antioxidants research, and the safe handling of antineoplastic drugs.

Frequent collaboration has been a hallmark of their research approach. Key coauthors associated with their work include Ines Batinić-Haberle, Artak Tovmasyan, Huaxin Sheng, Fan Ping, and Angeles Alvarez Secord. These collaborations have contributed to a broad and diverse research output.

The publication venues where Ivan Spasojevic's research appears most often reflect their interdisciplinary expertise. These venues include:

  • Free Radical Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Oxidative Medicine and Cellular Longevity
  • Antioxidants

Among their recent papers are studies addressing therapeutic efficacy, molecular pathways, and nanoparticle technologies in medicine:

  • Efficacy of osimertinib against EGFRvIII+ glioblastoma, 2020, Oncotarget
  • H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways, 2021, Oxidative Medicine and Cellular Longevity
  • Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke, 2021, Experimental Neurology
  • Genetically Encoded Stealth Nanoparticles of a Zwitterionic Polypeptide-Paclitaxel Conjugate Have a Wider Therapeutic Window than Abraxane in Multiple Tumor Models, 2020, Nano Letters
  • Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd), 2025, Nature Communications

The scope of Ivan Spasojevic's research integrates molecular and clinical perspectives, emphasizing translational approaches in oncology, neurology, and pharmacology. Their profile reveals a multidisciplinary engagement with emerging biomedical technologies and therapeutic strategies.

Best Publications

  • Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

    Ines Batinić-Haberle;Júlio S. Rebouças;Ivan Spasojević

  • Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

    Zachary J. Reitman;Genglin Jin;Edward D. Karoly;Ivan Spasojevic

  • Manganese superoxide dismutase, MnSOD and its mimics

    Sumitra Miriyala;Ivan Spasojevic;Artak Tovmasyan;Daniela Salvemini

  • Relationship among Redox Potentials, Proton Dissociation Constants of Pyrrolic Nitrogens, and in Vivo and in Vitro Superoxide Dismutating Activities of Manganese(III) and Iron(III) Water-Soluble Porphyrins

    † Ines Batinić-Haberle;Ivan Spasojević;Peter Hambright;Ludmil Benov

  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.

    Ines Batinic-Haberle;Ludmil Benov;Ivan Spasojevic;Irwin Fridovich

  • Urinary biomarkers of oxidative status.

    Dora Il'yasova;Peter Scarbrough;Ivan Spasojevic

  • SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

    Ines Batinic-Haberle;Artak Tovmasyan;Emily R. H. Roberts;Zeljko Vujaskovic

  • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

    Zeljko Vujaskovic;Ines Batinic-Haberle;Zahid N. Rabbani;Qin fu Feng

  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models

    Jayanta Bhattacharyya;Joseph J. Bellucci;Isaac Weitzhandler;Jonathan R. McDaniel

  • A joint analysis of metabolomics and genetics of breast cancer.

    Xiaohu Tang;Chao-Chieh Lin;Ivan Spasojevic;Edwin S Iversen

  • Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors

    Marlene L. Hauck;Susan M. LaRue;William P. Petros;Jean M. Poulson

  • New class of potent catalysts of O2˙− dismutation. Mn(III)ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins

    Ines Batinić-Haberle;Ivan Spasojević;Robert D. Stevens;Peter Hambright

  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.

    Gerardo Ferrer-Sueta;Ines Batinić-Haberle;Ivan Spasojević;Irwin Fridovich

  • A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin.

    Ines Batinić-Haberle;Stefan I. Liochev;Ivan Spasojević;Irwin Fridovich

  • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.

    Ines Batinić-Haberle;Salvatore Cuzzocrea;Júlio S. Rebouças;Gerardo Ferrer-Sueta

  • Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours

    Pavel S. Yarmolenko;Yulin Zhao;Chelsea Landon;Ivan Spasojevic

  • Manganese(III) meso-tetrakis(ortho-N-alkylpyridyl)porphyrins. Synthesis, characterization, and catalysis of O2˙− dismutation

    Ines Batinić-Haberle;Ivan Spasojević;Robert. D. Stevens;Peter Hambright

  • An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.

    Ines Batinic-Haberle;Artak Tovmasyan;Ivan Spasojevic

  • Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria.

    Ivan Spasojević;Yumin Chen;Teresa J. Noel;Yiqun Yu

  • Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

    Ines Batinic-Haberle;Zrinka Rajic;Artak Tovmasyan;Julio S. Reboucas

  • Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple.

    Ivan Spasojević;Ines Batinić-Haberle;Robert D. Stevens;Peter Hambright

Frequent Co-Authors

Ines Batinic-Haberle
Ines Batinic-Haberle Duke University
Mark W. Dewhirst
Mark W. Dewhirst Duke University
Irwin Fridovich
Irwin Fridovich Duke University
David S. Warner
David S. Warner Duke University
Alvin L. Crumbliss
Alvin L. Crumbliss Duke University
Daret K. St. Clair
Daret K. St. Clair University of Kentucky
Ting-Ting Huang
Ting-Ting Huang Stanford University
Ralph B. D'Agostino
Ralph B. D'Agostino Wake Forest University
Daniela Salvemini
Daniela Salvemini Saint Louis University
Darell D. Bigner
Darell D. Bigner Duke University

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