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Medicine

D-Index
86
Citations
34872
World Ranking
13936
National Ranking
7073

Overview

John M. Shelton is affiliated with The University of Texas Southwestern Medical Center in the United States. Their scientific contributions span the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with a particular focus on subfields including Molecular Biology, Cardiology and Cardiovascular Medicine, Genetics, Physiology, and Surgery.

The research topics they frequently address cover Muscle Physiology and Disorders, Congenital Heart Defects Research, CRISPR and Genetic Engineering, interferon and immune responses, Virus-based Gene Therapy Research, Epigenetics and DNA Methylation, and RNA Research and Splicing.

Some of their recent publications include:

  • Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system, 2020, Science Advances
  • TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity, 2021, Cell
  • Correction of Three Prominent Mutations in Mouse and Human Models of Duchenne Muscular Dystrophy by Single-Cut Genome Editing, 2020, Molecular Therapy
  • Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury, 2021, Circulation Research
  • Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling, 2020, Developmental Cell

Throughout their career, John M. Shelton has published in various scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Nature Communications
  • JCI Insight
  • Science Advances

They have collaborated frequently with a number of coauthors, most notably Bret M. Evers, Eric N. Olson, Aksharkumar Dobariya, Tarek Y. El Ahmadieh, and Levi B. Good, with multiple joint publications in each case.

Best Publications

  • Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

    Marion Trommsdorff;Michael Gotthardt;Thomas Hiesberger;John Shelton

  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

    Eva R. Chin;Eric N. Olson;James A. Richardson;Quan Yang

  • A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance

    Douglas M. Anderson;Kelly M. Anderson;Chi Lun Chang;Catherine A. Makarewich

  • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

    Takeshi Inagaki;Antonio Moschetta;Youn Kyoung Lee;Li Peng

  • Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

    Chengzu Long;Leonela Amoasii;Alex A. Mireault;John R. McAnally

  • Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

    Rick B. Vega;Koichi Matsuda;Junyoung Oh;Ana C. Barbosa

  • Hippo pathway effector Yap promotes cardiac regeneration

    Mei Xin;Yuri Kim;Lillian B. Sutherland;Masao Murakami

  • Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

    Debora Bryant;Lisa Becker;James A Richardson;John Shelton

  • Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

    Zoltan Arany;Huamei He;Jiandie Lin;Kirsten Hoyer

  • Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA

    Chengzu Long;John R. McAnally;John M. Shelton;Alex A. Mireault

  • Cardiac autophagy is a maladaptive response to hemodynamic stress

    Hongxin Zhu;Paul Tannous;Janet L. Johnstone;Yongli Kong

  • Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

    Marzia Scortegagna;Kan Ding;Yavuz Oktay;Arti Gaur

  • Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

    Christopher L. Antos;Timothy A. McKinsey;Norbert Frey;William Kutschke

  • MEF2 responds to multiple calcium‐regulated signals in the control of skeletal muscle fiber type

    Hai Wu;Francisco J. Naya;Timothy A. McKinsey;Brian Mercer

  • Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo

    Francisco J. Naya;Brian Mercer;John Shelton;James A. Richardson

  • Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

    Leonela Amoasii;John C.W. Hildyard;Hui Li;Efrain Sanchez-Ortiz

  • Myomaker is a membrane activator of myoblast fusion and muscle formation

    Douglas P. Millay;Jason R. O’Rourke;Lillian B. Sutherland;Svetlana Bezprozvannaya

  • MEF2C transcription factor controls chondrocyte hypertrophy and bone development

    Michael A. Arnold;Yuri Kim;Michael P. Czubryt;Dillon Phan

  • Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.

    Matthew J. Potthoff;Hai Wu;Michael A. Arnold;John M. Shelton

  • Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

    Michael Gotthardt;Marion Trommsdorff;Matthew F. Nevitt;John Shelton

Frequent Co-Authors

James A. Richardson
James A. Richardson The University of Texas Southwestern Medical Center
Eric N. Olson
Eric N. Olson The University of Texas Southwestern Medical Center
Rhonda Bassel-Duby
Rhonda Bassel-Duby The University of Texas Southwestern Medical Center
Joseph A. Hill
Joseph A. Hill The University of Texas Southwestern Medical Center
Beverly A. Rothermel
Beverly A. Rothermel The University of Texas Southwestern Medical Center
R. Sanders Williams
R. Sanders Williams Duke University
Daniel J. Garry
Daniel J. Garry University of Minnesota
Jian Huang
Jian Huang University of Iowa
Michael J. Bennett
Michael J. Bennett University Hospital Southampton NHS Foundation Trust
Ellen S. Vitetta
Ellen S. Vitetta The University of Texas Southwestern Medical Center

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